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Cardiac function and mortality of stem cell therapy in patients with coronary artery disease who underwent coronary artery bypass graft without heart failure: A meta‑analysis

  • Authors:
    • Thanut Jansirirat
    • Sittichai Khamsai
    • Kittisak Sawanyawisuth
  • View Affiliations / Copyright

    Affiliations: Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
    Copyright: © Jansirirat et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 147
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    Published online on: June 24, 2025
       https://doi.org/10.3892/br.2025.2025
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Abstract

Coronary artery disease (CAD) is a common disease and can be treated with coronary artery bypass grafting (CABG) in specific cases. Stem cell therapy has been shown to be effective in patients with CAD who underwent CABG in several settings but limited to those without heart failure. The aim of the present study was to evaluate whether stem cell therapy is effective in patients with CAD who underwent CABG and had no heart failure. The present systematic review investigated wether there was any improvement in cardiac function or reduction of mortality in patients with CAD who received CABG and did not have heart failure. The types of studies included in this systematic review were randomized controlled trials. In total, four databases were used for a systematic search: PubMed, CENTRAL database, Scopus, and CINAHL Plus. The results were reported as the mean difference of left ventricular ejection fraction (LVEF) and risk ratio of mortality rate between stem cell therapy vs. controls. There were 125 studies retrieved from a search in the four aforementioned databases; of those, seven studies met the study criteria. Regarding the outcome of cardiac function, the standardized mean difference of LVEF between the experimental and the control groups was 0.17 (95% CI: ‑0.09, 0.44). The risk ratio of mortality was also not statistically significant (1.59; 95% CI: 0.68, 3.73). Stem cell therapy did not exert significant improvement of the LVEF or the mortality rate compared with controls, in patients with CAD who underwent CABG and had no heart failure. Further studies are required to confirm the results of the present study.
View Figures

Figure 1

PRISMA flowchart for cardiac function
and mortality of stem cell therapy in patients with coronary artery
disease without heart failure who underwent coronary artery bypasss
grafting. EF, ejection fraction; RCT, randomized controlled
trial.

Figure 2

Forest plot of left ventricular
ejection fraction between the stem cell therapy and control groups
in patients with coronary artery disease without heart failure who
underwent coronary artery bypass graft. Std., standardized; df,
degree of freedom; IC, intracoronary; IM intramuscular.

Figure 3

Forest plot of the mortality rate
between the stem cell therapy and control groups in patients with
coronary artery disease without heart failure who underwent
coronary artery bypass graft. Std., standardized; df, degree of
freedom; IC, intracoronary; IM intramuscular.

Figure 4

Bias assessment of included studies on
stem cell therapy in patients with coronary artery disease without
heart failure who underwent coronary artery bypass graft: Ejection
fraction as an outcome.

Figure 5

Bias assessment of included studies on
stem cell therapy in patients with coronary artery disease without
heart failure who underwent coronary artery bypass graft: Mortality
as an outcome.
View References

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Copy and paste a formatted citation
Spandidos Publications style
Jansirirat T, Khamsai S and Sawanyawisuth K: Cardiac function and mortality of stem cell therapy in patients with coronary artery disease who underwent coronary artery bypass graft without heart failure: A meta‑analysis. Biomed Rep 23: 147, 2025.
APA
Jansirirat, T., Khamsai, S., & Sawanyawisuth, K. (2025). Cardiac function and mortality of stem cell therapy in patients with coronary artery disease who underwent coronary artery bypass graft without heart failure: A meta‑analysis. Biomedical Reports, 23, 147. https://doi.org/10.3892/br.2025.2025
MLA
Jansirirat, T., Khamsai, S., Sawanyawisuth, K."Cardiac function and mortality of stem cell therapy in patients with coronary artery disease who underwent coronary artery bypass graft without heart failure: A meta‑analysis". Biomedical Reports 23.3 (2025): 147.
Chicago
Jansirirat, T., Khamsai, S., Sawanyawisuth, K."Cardiac function and mortality of stem cell therapy in patients with coronary artery disease who underwent coronary artery bypass graft without heart failure: A meta‑analysis". Biomedical Reports 23, no. 3 (2025): 147. https://doi.org/10.3892/br.2025.2025
Copy and paste a formatted citation
x
Spandidos Publications style
Jansirirat T, Khamsai S and Sawanyawisuth K: Cardiac function and mortality of stem cell therapy in patients with coronary artery disease who underwent coronary artery bypass graft without heart failure: A meta‑analysis. Biomed Rep 23: 147, 2025.
APA
Jansirirat, T., Khamsai, S., & Sawanyawisuth, K. (2025). Cardiac function and mortality of stem cell therapy in patients with coronary artery disease who underwent coronary artery bypass graft without heart failure: A meta‑analysis. Biomedical Reports, 23, 147. https://doi.org/10.3892/br.2025.2025
MLA
Jansirirat, T., Khamsai, S., Sawanyawisuth, K."Cardiac function and mortality of stem cell therapy in patients with coronary artery disease who underwent coronary artery bypass graft without heart failure: A meta‑analysis". Biomedical Reports 23.3 (2025): 147.
Chicago
Jansirirat, T., Khamsai, S., Sawanyawisuth, K."Cardiac function and mortality of stem cell therapy in patients with coronary artery disease who underwent coronary artery bypass graft without heart failure: A meta‑analysis". Biomedical Reports 23, no. 3 (2025): 147. https://doi.org/10.3892/br.2025.2025
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