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Follow-up study of vonoprazan maintenance therapy for reflux esophagitis: A 96-week evaluation in patients with PPI-refractory disease

  • Authors:
    • Hideki Mizuno
    • Shingo Inagaki
    • Kazutoshi Yamada
    • Shinji Kamiyamamoto
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, Toyama City Hospital, Toyama 939-8511, Japan
    Copyright: © Mizuno et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Article Number: 160
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    Published online on: July 30, 2025
       https://doi.org/10.3892/br.2025.2038
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Abstract

Vonoprazan is a potassium-competitive acid blocker that provides more potent and sustained acid suppression than conventional proton pump inhibitors (PPIs). Vonoprazan may serve a role in the long-term management of gastroesophageal reflux disease (GERD), particularly in patients with reflux esophagitis (RE) who are unresponsive to PPIs. The present study aimed to evaluate the safety, tolerability and efficacy of vonoprazan over a 96-week period in patients with PPI-refractory RE. Initially, 74 patients received vonoprazan 20 mg once daily for 4 weeks. Patients who demonstrated mucosal healing transitioned to vonoprazan 10 mg once daily for a 48-week maintenance phase. Of these, 43 patients continued therapy for an additional 48 weeks. Endoscopic evaluation, symptom scores using the Frequency Scale for the Symptoms of GERD and serum gastrin levels were monitored to assess treatment outcomes and safety. By the end of the 96-week maintenance period, 85.7% of patients who completed follow-up showed no recurrence of mucosal lesions. Among those who discontinued therapy following symptom resolution, 45.8% experienced symptom relapse; however, these patients responded well to reintroduction of vonoprazan. Although serum gastrin levels in the continuous maintenance therapy remained elevated, no adverse events such as carcinoid tumors were reported. These findings suggested that vonoprazan was both effective and well-tolerated as a long-term maintenance therapy for RE and may serve as a viable on-demand treatment strategy for relapse management. While the results are promising, they stem from a highly selected population. Therefore, further randomized, controlled trials are warranted to confirm the generalizability and long-term safety of vonoprazan in broader GERD populations.
View Figures

Figure 1

Flow chart of study design.
Symptomatic recurrence was defined as acid reflux-related symptoms
(3 consecutive days of moderate/severe heartburn and acid
regurgitation). RE, reflux esophagitis; PPI, proton pump inhibitor;
EGD, esophagogastroduodenoscopy.

Figure 2

Distribution of Los Angeles
classification grades before starting PPI therapy and following
maintenance therapy with vonoprazan (10 mg) up to 96 weeks
(per-protocol population). PPI, proton pump inhibitor.

Figure 3

Kaplan-Meier curves depicting
patients who did not experience symptom relapse over the 96-week
vonoprazan maintenance period. Patients who were lost to follow-up
or voluntarily discontinued therapy without documented symptom
recurrence were censored at their last observation point.

Figure 4

FSSG scores before and after VPZ (20
mg) retreatment in patients with symptom recurrence (n=11). Changes
in (A) total, (B) acid reflux-related and (C) dysmotility symptom
scores of the FSSG. *P<0.05 vs. point of symptom
recurrence. FSSG, Frequency Scale for the Symptoms of
gastroesophageal reflux disease; VPZ, vonoprazan.
View References

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Mizuno H, Inagaki S, Yamada K and Kamiyamamoto S: Follow-up study of vonoprazan maintenance therapy for reflux esophagitis: A 96-week evaluation in patients with PPI-refractory disease. Biomed Rep 23: 160, 2025.
APA
Mizuno, H., Inagaki, S., Yamada, K., & Kamiyamamoto, S. (2025). Follow-up study of vonoprazan maintenance therapy for reflux esophagitis: A 96-week evaluation in patients with PPI-refractory disease. Biomedical Reports, 23, 160. https://doi.org/10.3892/br.2025.2038
MLA
Mizuno, H., Inagaki, S., Yamada, K., Kamiyamamoto, S."Follow-up study of vonoprazan maintenance therapy for reflux esophagitis: A 96-week evaluation in patients with PPI-refractory disease". Biomedical Reports 23.4 (2025): 160.
Chicago
Mizuno, H., Inagaki, S., Yamada, K., Kamiyamamoto, S."Follow-up study of vonoprazan maintenance therapy for reflux esophagitis: A 96-week evaluation in patients with PPI-refractory disease". Biomedical Reports 23, no. 4 (2025): 160. https://doi.org/10.3892/br.2025.2038
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Spandidos Publications style
Mizuno H, Inagaki S, Yamada K and Kamiyamamoto S: Follow-up study of vonoprazan maintenance therapy for reflux esophagitis: A 96-week evaluation in patients with PPI-refractory disease. Biomed Rep 23: 160, 2025.
APA
Mizuno, H., Inagaki, S., Yamada, K., & Kamiyamamoto, S. (2025). Follow-up study of vonoprazan maintenance therapy for reflux esophagitis: A 96-week evaluation in patients with PPI-refractory disease. Biomedical Reports, 23, 160. https://doi.org/10.3892/br.2025.2038
MLA
Mizuno, H., Inagaki, S., Yamada, K., Kamiyamamoto, S."Follow-up study of vonoprazan maintenance therapy for reflux esophagitis: A 96-week evaluation in patients with PPI-refractory disease". Biomedical Reports 23.4 (2025): 160.
Chicago
Mizuno, H., Inagaki, S., Yamada, K., Kamiyamamoto, S."Follow-up study of vonoprazan maintenance therapy for reflux esophagitis: A 96-week evaluation in patients with PPI-refractory disease". Biomedical Reports 23, no. 4 (2025): 160. https://doi.org/10.3892/br.2025.2038
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