Aortitis after granulocyte‑colony stimulating factor administration: A case report

Fujiwara,Shuichi; Hara,Hitomi; Fukase,Naomasa; Sawada,Ryoko; Takemori,Toshiyuki; Miyamoto,Tomohiro; Nakamatsu,Yuta; Kuroda,Ryosuke; Akisue,Toshihiro

doi:10.3892/br.2025.2039

October-2025 Volume 23 Issue 4

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October-2025 Volume 23 Issue 4

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Case Report

Aortitis after granulocyte‑colony stimulating factor administration: A case report

Authors:
- Shuichi Fujiwara
- Hitomi Hara
- Naomasa Fukase
- Ryoko Sawada
- Toshiyuki Takemori
- Tomohiro Miyamoto
- Yuta Nakamatsu
- Ryosuke Kuroda
- Toshihiro Akisue
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Affiliations: Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Hyogo 650‑0017, Japan
Article Number: 161
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Published online on: July 30, 2025

https://doi.org/10.3892/br.2025.2039
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Abstract

Granulocyte‑colony stimulating factor (G‑CSF) is commonly used to reduce neutropenia‑related complications following chemotherapy. It is a glycoprotein that stimulates the production of granulocytes [white blood cells (WBCs) in the bone marrow. In the present study, the case of a 59‑year‑old man is presented who received chemotherapy (eribulin) for liver metastases from sacral chordoma and subsequently developed acute aortitis after the administration of G‑CSF. Grade 3 neutropenia occurred on day eight of the fifth chemotherapy cycle, and pegfilgrastim was administered on day nine. A total of 3 days after pegfilgrastim administration, the patient developed a fever that persisted for 6 days. He visited our hospital on day 18 with abdominal pain and elevated WBC count and C‑reactive protein levels. Febrile neutropenia was suspected, and antibiotics were administered. However, both blood and urinalysis cultures returned negative results, and antibiotics were ineffective. Contrast‑enhanced computed tomography revealed a thickened wall of the brachiocephalic artery and abdominal aorta, consistent with aortitis. After discontinuing the antibiotics, the patient was monitored closely without further treatment. His condition improved within a few days; therefore, it was concluded that aortitis was induced by G‑CSF.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Aortitis after granulocyte‑colony stimulating factor administration: A case report

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