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Efficacy of 12‑month romosozumab monotherapy or combination with eldecalcitol in patients with osteoporosis with and without chronic kidney disease: A real‑world retrospective study

  • Authors:
    • Teruya Uchiyama
    • Koichiro Murata
    • Toshibumi Kono
    • Masahiro Hasegawa
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    Affiliations: Department of Orthopaedic Surgery, Tomidahama Hospital, Yokkaichi, Mie 510‑8008, Japan, Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, Tsu, Mie 514‑8507, Japan
    Copyright: © Uchiyama et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 166
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    Published online on: August 18, 2025
       https://doi.org/10.3892/br.2025.2044
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Abstract

Evidence regarding the clinical benefits of combination therapy with romosozumab and active vitamin D analogs in the treatment of osteoporosis is lacking. The aim of the present study was to evaluate the outcome of romosozumab (ROMO) as well as ROMO + eldecalcitol (ELD) treatment in patients with osteoporosis with and without chronic kidney disease (CKD). Data from 146 patients who were administered ROMO was retrospectively investigated. Patients were classified into two groups based on estimated glomerular filtration rate (eGFR): CKD (eGFR <60 ml/min/1.73 m2; N=64) and non‑CKD (eGFR ≥60 ml/min/1.73 m2; N=82) groups. A total of 15 patients in the CKD and 18 in the non‑CKD group received ROMO + ELD treatment. The primary outcomes were bone mineral density (BMD) responses in the lumbar spine (LS) and femoral neck (FN). The combined impact of ROMO + ELD treatment was also assessed. The LS BMD was significantly increased in the both groups after 12 months of treatment compared with that at baseline. The FN BMD value was not significantly altered from baseline in both groups, and there were no significant differences in the LS and FN BMD increases between the groups. In the CKD group, the percentage changes in the FN BMD and serum procollagen type I N‑terminal propeptide levels observed with ROMO + ELD treatment were greater than those with ROMO monotherapy. ROMO demonstrated efficacy in the treatment of osteoporosis, irrespective of renal function. ROMO + ELD treatment may be beneficial for patients with CKD.
View Figures

Figure 1

Flow chart of the study population.
CKD, chronic kidney disease; eGFR, estimated glomerular filtration
rate; ELD, eldecalcitol.

Figure 2

Mean percent changes from month 0 to
month 12 in (A) LS BMD, (B) FN BMD, and (C) PINP. Bars indicate (A
and B) the mean ± standard error, and (C) the median ± standard
error. **P<0.05, ***P<0.001 and n.s.
compared to baseline (repeated measures ANOVA);
#P<0.05 between the groups (Mann-Whitney U test).
BMD, bone mineral density; LS, lumbar spine; FN, femoral neck;
PINP, procollagen type I N-terminal propeptide; CKD, chronic kidney
disease; n.s., not significant.

Figure 3

Mean percent changes from month 0 to
month 12 in (A) LS BMD, (B) FN BMD, and (C) PINP in the CKD group.
Bars indicate (A and B) the mean ± standard error, and (C) the
median ± standard error. ***P<0.001 and n.s. compared
to baseline (repeated measures ANOVA). BMD, bone mineral density;
LS, lumbar spine; FN, femoral neck; PINP, procollagen type I
N-terminal propeptide; R, romosozumab; ELD, eldecalcitol; n.s., not
significant.

Figure 4

Mean percent changes from month 0 to
month 12 in (A) LS BMD, (B) FN BMD, and (C) PINP in the non-CKD
group. Bars indicate (A and B) the mean ± standard error, and (C)
the median ± standard error. ***P<0.001 and n.s.
compared to baseline (repeated measures ANOVA). BMD, bone mineral
density; LS, lumbar spine; FN, femoral neck; PINP, procollagen type
I N-terminal propeptide; R, romosozumab; ELD, eldecalcitol; n.s.,
not significant.
View References

1 

de Villiers TJ and Goldstein SR: Bone health 2022: An update. Climacteric. 25:1–3. 2022.PubMed/NCBI View Article : Google Scholar

2 

Borgström F, Karlsson L, Ortsäter G, Norton N, Halbout P, Cooper C, Lorentzon M, McCloskey EV, Harvey NC, Javaid MK, et al: Fragility fractures in Europe: Burden, management and opportunities. Arch Osteoporos. 15(59)2020.PubMed/NCBI View Article : Google Scholar

3 

Hanafusa N, Abe M, Joki N, Hoshino J, Kikuchi K, Goto S, Kanda E, Taniguchi M, Nakai S, Naganuma T, et al: Annual dialysis data report. 2020, JSDT Renal Data Registry. Ren Replace Ther. 10(14)2024.

4 

GBD Chronic Kidney Disease Collaboration. Global, regional, and national burden of chronic kidney disease, 1990-2017: A systematic analysis for the global burden of disease study 2017. Lancet. 395:709–733. 2020.PubMed/NCBI View Article : Google Scholar

5 

Nickolas TL, McMahon DJ and Shane E: Relationship between moderate to severe kidney disease and hip fracture in the United States. J Am Soc Nephrol. 17:3223–3232. 2006.PubMed/NCBI View Article : Google Scholar

6 

Tentori F, McCullough K, Kilpatrick RD, Bradbury BD, Robinson BM, Kerr PG and Pisoni RL: High rates of death and hospitalization follow bone fracture among hemodialysis patients. Kidney Int. 85:166–173. 2014.PubMed/NCBI View Article : Google Scholar

7 

Chen CH, Lo WC, Hu PJ, Chan HC, Shen WC, Wu MS and Wu MY: Efficacy of osteoporosis medications for patients with chronic kidney disease: An updated systematic review and network meta-analysis. Front Pharmacol. 13(822178)2022.PubMed/NCBI View Article : Google Scholar

8 

Thongprayoon C, Acharya P, Acharya C, Chenbhanich J, Bathini T, Boonpheng B, Sharma K, Wijarnpreecha K, Ungprasert P, Gonzalez Suarez ML and Cheungpasitporn W: Hypocalcemia and bone mineral density changes following denosumab treatment in end-stage renal disease patients: A meta-analysis of observational studies. Osteoporos Int. 29:1737–1745. 2018.PubMed/NCBI View Article : Google Scholar

9 

Sumida K, Ubara Y, Hoshino J, Mise K, Hayami N, Suwabe T, Kawada M, Imafuku A, Hiramatsu R, Hasegawa E, et al: Once-weekly teriparatide in hemodialysis patients with hypoparathyroidism and low bone mass: A prospective study. Osteoporos Int. 27:1441–1450. 2016.PubMed/NCBI View Article : Google Scholar

10 

Cosman F, Crittenden DB, Adachi JD, Binkley N, Czerwinski E, Ferrari S, Hofbauer LC, Lau E, Lewiecki EM, Miyauchi A, et al: Romosozumab treatment in postmenopausal women with osteoporosis. N Engl J Med. 375:1532–1543. 2016.PubMed/NCBI View Article : Google Scholar

11 

Miyauchi A, Hamaya E, Nishi K, Tolman C and Shimauchi J: Efficacy and safety of romosozumab among Japanese postmenopausal women with osteoporosis and mild-to-moderate chronic kidney disease. J Bone Miner Metab. 40:677–687. 2022.PubMed/NCBI View Article : Google Scholar

12 

Miller PD, Adachi JD, Albergaria BH, Cheung AM, Chines AA, Gielen E, Langdahl BL, Miyauchi A, Oates M, Reid IR, et al: Efficacy and safety of romosozumab among postmenopausal women with osteoporosis and mild-to-moderate chronic kidney disease. J Bone Miner Res. 37:1437–1445. 2022.PubMed/NCBI View Article : Google Scholar

13 

LaClair RE, Hellman RN, Karp SL, Kraus M, Ofner S, Li Q, Graves KL and Moe SM: Prevalence of calcidiol deficiency in CKD: A cross-sectional study across latitudes in the United States. Am J Kidney Dis. 45:1026–1033. 2005.PubMed/NCBI View Article : Google Scholar

14 

Craver L, Marco MP, Martínez I, Rue M, Borràs M, Martín ML, Sarró F, Valdivielso JM and Fernández E: Mineral metabolism parameters throughout chronic kidney disease stages 1-5-achievement of K/DOQI target ranges. Nephrol Dial Transplant. 22:1171–1176. 2007.PubMed/NCBI View Article : Google Scholar

15 

Kidney Disease: Improving Global Outcomes (KDIGO) CKD-MBD Update Work Group: KDIGO 2017 clinical practice guideline update for the diagnosis, evaluation, prevention, and treatment of chronic kidney disease-mineral and bone disorder (CKD-MBD). Kidney Int Suppl (2011). 7:1–59. 2017.PubMed/NCBI View Article : Google Scholar

16 

Pluskiewicz W, Adamczyk P, Czekajło A, Grzeszczak W, Burak W and Drozdzowska B: Epidemiological data on osteoporosis in women from the RAC-OST-POL study. J Clin Densitom. 15:308–314. 2012.PubMed/NCBI View Article : Google Scholar

17 

United Nations Department of Economic and Social Affairs, Population Division. World Population Prospects 2022: Summary of Results. UN DESA/POP/2022/TR/NO. 3, 2022.

18 

Saito K, Miyakoshi N, Matsunaga T, Hongo M, Kasukawa Y and Shimada Y: Eldecalcitol improves muscle strength and dynamic balance in postmenopausal women with osteoporosis: An open-label randomized controlled study. J Bone Miner Metab. 34:547–554. 2016.PubMed/NCBI View Article : Google Scholar

19 

Ling Y, Xu F, Xia X, Dai D, Xiong A, Sun R, Qiu L and Xie Z: Vitamin D supplementation reduces the risk of fall in the vitamin D deficient elderly: An updated meta-analysis. Clin Nutr. 40:5531–5537. 2021.PubMed/NCBI View Article : Google Scholar

20 

Matsuo S, Imai E, Horio M, Yasuda Y, Tomita K, Nitta K, Yamagata K, Tomino Y, Yokoyama H and Hishida A: Collaborators developing the Japanese equation for estimated GFR. Revised equations for estimated GFR from serum creatinine in Japan. Am J Kidney Dis. 53:982–992. 2009.PubMed/NCBI View Article : Google Scholar

21 

Kobayakawa T, Miyazaki A, Takahashi J and Nakamura Y: Effects of romosozumab with and without active vitamin D analog supplementation for postmenopausal osteoporosis. Clin Nutr Espen. 48:267–274. 2022.PubMed/NCBI View Article : Google Scholar

22 

U.S. Department of Health and Human Services. Common terminology criteria for. adverse events (CTCAE) version 5.0. National Institutes of Health, National Cancer. Institute, 2017. https://ctep.cancer.gov/protocolDevelopment/electronic_applications/ctc.htm. Accessed February 27, 2025.

23 

Faber BG, Frysz M, Boer CG, Evans DS, Ebsim R, Flynn KA, Lundberg M, Southam L, Hartley A, Saunders FR, et al: The identification of distinct protective and susceptibility mechanisms for hip osteoarthritis: Findings from a genome-wide association study meta-analysis of minimum joint space width and Mendelian randomisation cluster analyses. EBioMedicine. 95(104759)2023.PubMed/NCBI View Article : Google Scholar

24 

Nakao H, Yokomoto-Umakoshi M, Nakatani K, Umakoshi H, Ogata M, Fukumoto T, Kaneko H, Iwahashi N, Fujita M, Ogasawara T, et al: Adrenal steroid metabolites and bone status in patients with adrenal incidentalomas and hypercortisolism. EBioMedicine. 95(104733)2023.PubMed/NCBI View Article : Google Scholar

25 

Ebeling PR, Nguyen HH, Aleksova J, Vincent AJ, Wong P and Milat F: Secondary osteoporosis. Endocr Rev. 43:240–313. 2022.PubMed/NCBI View Article : Google Scholar

26 

Dong L, Jiang L, Xu Z and Zhang X: Denosumab, teriparatide and bisphosphonates for glucocorticoid-induced osteoporosis: A Bayesian network meta-analysis. Front Pharmacol. 15(1336075)2024.PubMed/NCBI View Article : Google Scholar

27 

Liu H, Xiao H, Lin S, Zhou H, Cheng Y, Xie B and Xu D: Effect of gut hormones on bone metabolism and their possible mechanisms in the treatment of osteoporosis. Front Pharmacol. 15(1372399)2024.PubMed/NCBI View Article : Google Scholar

28 

Rodríguez V, Rivoira M, Picotto G, de Barboza GD, Collin A and Tolosa de Talamoni N: Analysis of the molecular mechanisms by flavonoids with potential use for osteoporosis prevention or therapy. Curr Med Chem. 29:2913–2936. 2022.PubMed/NCBI View Article : Google Scholar

29 

Yu B, Gao Q, Sheng S, Zhou F, Geng Z, Wei Y, Zhang H, Hu Y, Wang S, Huang J, et al: Smart osteoclasts targeted nanomedicine based on amorphous CaCO3 for effective osteoporosis reversal. J Nanobiotechnology. 22(153)2024.PubMed/NCBI View Article : Google Scholar

30 

Zhao L, Cai C, Wang J, Zhao L, Li W, Liu C, Guan H, Zhu Y and Xiao J: Dihydromyricetin. protects against bone loss in ovariectomized mice by suppressing osteoclast activity. Front Pharmacol. 8(928)2017.PubMed/NCBI View Article : Google Scholar

31 

Xu L, Sun X, Han X, Li H, Li X, Zhu L, Wang X, Li J and Sun H: Dihydromyricetin ameliorate postmenopausal osteoporosis in ovariectomized mice: Integrative microbiomic and metabolomic analysis. Front Pharmacol. 15(1452921)2024.PubMed/NCBI View Article : Google Scholar

32 

Chen YJ, Jia LH, Han TH, Zhao ZH, Yang J, Xiao JP, Yang HJ and Yang K: Osteoporosis treatment: Current drugs and future developments. Front Pharmacol. 15(1456796)2024.PubMed/NCBI View Article : Google Scholar

33 

Deng TT, Ding WY, Lu XX, Zhang QH, Du JX, Wang LJ, Yang MN, Yin Y and Liu FJ: Pharmacological and mechanistic aspects of quercetin in osteoporosis. Front Pharmacol. 15(1338951)2024.PubMed/NCBI View Article : Google Scholar

34 

Wu Y, Song P, Wang M, Liu H, Jing Y and Su J: Extracellular derivatives for bone metabolism. J Adv Res. 66:329–347. 2024.PubMed/NCBI View Article : Google Scholar

35 

Zeng ZL and Xie H: Mesenchymal stem cell-derived extracellular vesicles: A possible therapeutic strategy for orthopaedic diseases: A narrative review. Biomater Transl. 3:175–187. 2022.PubMed/NCBI View Article : Google Scholar

36 

Yeung WG, Palmer SC, Strippoli GFM, Talbot B, Shah N, Hawley CM, Toussaint ND and Badve SV: Vitamin D therapy in adults with CKD: A systematic review and meta-analysis. Am J Kidney Dis. 82:543–558. 2023.PubMed/NCBI View Article : Google Scholar

37 

Kikuta J, Kawamura S, Okiji F, Shirazaki M, Sakai S, Saito H and Ishii M: Sphingosine-1-phosphate-mediated osteoclast precursor monocyte migration is a critical point of control in antibone-resorptive action of active vitamin D. Proc Natl Acad Sci USA. 110:7009–7013. 2013.PubMed/NCBI View Article : Google Scholar

38 

McClung MR, Grauer A, Boonen S, Bolognese MA, Brown JP, Diez-Perez A, Langdahl BL, Reginster JY, Zanchetta JR, Wasserman SM, et al: Romosozumab in postmenopausal women with low bone mineral density. N Engl J Med. 370:412–420. 2014.PubMed/NCBI View Article : Google Scholar

39 

Movérare-Skrtic S, Voelkl J, Nilsson KH, Nethander M, Luong TTD, Alesutan I, Li L, Wu J, Horkeby K, Lagerquist MK, et al: B4GALNT3 regulates glycosylation of sclerostin and bone mass. EBioMedicine. 91(104546)2023.PubMed/NCBI View Article : Google Scholar

40 

Valverde MG, Mille LS, Figler KP, Cervantes E, Li VY, Bonventre JV, Masereeuw R and Zhang YS: Biomimetic models of the glomerulus. Nat Rev Nephrol. 18:241–257. 2022.PubMed/NCBI View Article : Google Scholar

41 

Sakai S, Endo K, Takeda S, Mihara M and Shiraishi A: Combination therapy with eldecalcitol and alendronate has therapeutic advantages over monotherapy by improving bone strength. Bone. 50:1054–1063. 2012.PubMed/NCBI View Article : Google Scholar

42 

Nakamura Y, Suzuki T, Kamimura M, Murakami K, Ikegami S, Uchiyama S and Kato H: Vitamin D and calcium are required at the time of denosumab administration during osteoporosis treatment. Bone Res. 5(17021)2017.PubMed/NCBI View Article : Google Scholar

43 

Suzuki T, Nakamura Y and Kato H: Effects of monthly minodronate with or without eldecalcitol addition in osteoporosis patients with rheumatoid arthritis: An 18-month prospective study. Osteoporos Sarcopenia. 5:122–127. 2019.PubMed/NCBI View Article : Google Scholar

44 

Kondo S, Takano T, Ono Y, Saito H and Matsumoto T: Eldecalcitol reduces osteoporotic fractures by unique mechanisms. J Steroid Biochem Mol Biol. 148:232–238. 2015.PubMed/NCBI View Article : Google Scholar

45 

Kashii M, Kamatani T, Nagayama Y, Miyama A, Tsuboi H and Ebina K: Baseline serum PINP level is associated with the increase in hip bone mineral density seen with romosozumab treatment in previously untreated women with osteoporosis. Osteoporos Int. 34:563–572. 2023.PubMed/NCBI View Article : Google Scholar

46 

Takada J, Dinavahi R, Miyauchi A, Hamaya E, Hirama T, Libanati C, Nakamura Y, Milmont CE and Grauer A: Relationship between P1NP, a biochemical marker of bone turnover, and bone mineral density in patients transitioned from alendronate to romosozumab or teriparatide: A post hoc analysis of the STRUCTURE trial. J Bone Miner Metab. 38:310–315. 2020.PubMed/NCBI View Article : Google Scholar

47 

Hattori K and Kanayama Y: Association between P1NP value and increases in bone mineral density in patients with postmenopausal osteoporosis treated with romosozumab. Mod Rheumatol. 34:1047–1055. 2024.PubMed/NCBI View Article : Google Scholar

48 

Ishimura E, Nishizawa Y, Inaba M, Matsumoto N, Emoto M, Kawagishi T, Shoji S, Okuno S, Kim M, Miki T and Morii H: Serum levels of 1,25-dihydroxyvitamin D, 24,25-dihydroxyvitamin D, and 25-hydroxyvitamin D in nondialyzed patients with chronic renal failure. Kidney Int. 55:1019–1027. 1999.PubMed/NCBI View Article : Google Scholar

49 

Pignolo RJ: Aging and bone metabolism. Compr Physiol. 13:4355–4386. 2023.PubMed/NCBI View Article : Google Scholar

50 

McCalden RW, McGeough JA and Court-Brown CM: Age-related changes in the compressive strength of cancellous bone. The relative importance of changes in density and trabecular architecture. J Bone Joint Surg Am. 79:421–427. 1997.PubMed/NCBI View Article : Google Scholar

51 

Chen H, Zhou X, Fujita H, Onozuka M and Kubo KY: Age-related changes in trabecular and cortical bone microstructure. Int J Endocrinol. 2013(213234)2013.PubMed/NCBI View Article : Google Scholar

52 

Ravaioli F, Pivetti A, Di Macro L, Chrysanthi C, Frassanito G, Pambianco M, Sicuro C, Gualandi N, Guasconi T, Pecchini M and Colecchia A: Role of vitamin D in liver disease and complications of advanced chronic liver disease. Int J Mol Sci. 23(9016)2022.PubMed/NCBI View Article : Google Scholar

53 

Konstantakis C, Tselekouni P, Kalafateli M and Triantos C: Vitamin D deficiency in patients with liver cirrhosis. Ann Gastroenterol. 29:297–306. 2016.PubMed/NCBI View Article : Google Scholar

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Uchiyama T, Murata K, Kono T and Hasegawa M: Efficacy of 12‑month romosozumab monotherapy or combination with eldecalcitol in patients with osteoporosis with and without chronic kidney disease: A real‑world retrospective study. Biomed Rep 23: 166, 2025.
APA
Uchiyama, T., Murata, K., Kono, T., & Hasegawa, M. (2025). Efficacy of 12‑month romosozumab monotherapy or combination with eldecalcitol in patients with osteoporosis with and without chronic kidney disease: A real‑world retrospective study. Biomedical Reports, 23, 166. https://doi.org/10.3892/br.2025.2044
MLA
Uchiyama, T., Murata, K., Kono, T., Hasegawa, M."Efficacy of 12‑month romosozumab monotherapy or combination with eldecalcitol in patients with osteoporosis with and without chronic kidney disease: A real‑world retrospective study". Biomedical Reports 23.4 (2025): 166.
Chicago
Uchiyama, T., Murata, K., Kono, T., Hasegawa, M."Efficacy of 12‑month romosozumab monotherapy or combination with eldecalcitol in patients with osteoporosis with and without chronic kidney disease: A real‑world retrospective study". Biomedical Reports 23, no. 4 (2025): 166. https://doi.org/10.3892/br.2025.2044
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Spandidos Publications style
Uchiyama T, Murata K, Kono T and Hasegawa M: Efficacy of 12‑month romosozumab monotherapy or combination with eldecalcitol in patients with osteoporosis with and without chronic kidney disease: A real‑world retrospective study. Biomed Rep 23: 166, 2025.
APA
Uchiyama, T., Murata, K., Kono, T., & Hasegawa, M. (2025). Efficacy of 12‑month romosozumab monotherapy or combination with eldecalcitol in patients with osteoporosis with and without chronic kidney disease: A real‑world retrospective study. Biomedical Reports, 23, 166. https://doi.org/10.3892/br.2025.2044
MLA
Uchiyama, T., Murata, K., Kono, T., Hasegawa, M."Efficacy of 12‑month romosozumab monotherapy or combination with eldecalcitol in patients with osteoporosis with and without chronic kidney disease: A real‑world retrospective study". Biomedical Reports 23.4 (2025): 166.
Chicago
Uchiyama, T., Murata, K., Kono, T., Hasegawa, M."Efficacy of 12‑month romosozumab monotherapy or combination with eldecalcitol in patients with osteoporosis with and without chronic kidney disease: A real‑world retrospective study". Biomedical Reports 23, no. 4 (2025): 166. https://doi.org/10.3892/br.2025.2044
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