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Impact of vascular risk factors on endovascular mechanical thrombectomy outcomes in patients with stroke

  • Authors:
    • Walaa A. Aldarwish
    • Shahid Bashir
    • Eman Mohammed Ali
    • Bader Alenzi
  • View Affiliations / Copyright

    Affiliations: Neurology Department, Neuroscience Center, King Fahad Specialist Hospital‑Dammam, Dammam 32253‑3202, Saudi Arabia, Neuroscience Center, King Fahad Specialist Hospital‑Dammam, Dammam 32253‑3202, Saudi Arabia
    Copyright: © Aldarwish et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 168
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    Published online on: August 26, 2025
       https://doi.org/10.3892/br.2025.2046
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Abstract

Endovascular mechanical thrombectomy (MT) is a recommended treatment for acute ischemic stroke due to large vessel occlusion (LVO). The objective of the present study was to evaluate the impact of vascular risk factors on the outcome of MT outcomes in patients with stroke with LVO and to determine the prevalence of structural epilepsy in these patients. This was a retrospective cohort study involving patients with stroke between 20 and 80 years of age with LVO who underwent MT. The clinical outcomes post‑MT were assessed using the Modified Thrombolysis in Cerebral Infarction score. A total of 56 individuals were included in the study, with a structural epilepsy prevalence of 14.29%. Patients who received intravenous tissue plasminogen activator (TPA) in addition to MT were less likely to develop structural epilepsy (P=0.041). A substantial number of patients (85.8%, combined Grades 3 and 2B) achieved successful reperfusion. The significant risk factors for hemorrhagic transformation include age [odds ratio (OR), 2.5; 95% CI: 1.8‑3.6; P=0.001], hypertension (OR, 3; 95% CI: 2.2‑4.1; P<0.001), diabetes (OR, 1.8; 95% CI: 1.2‑2.7; P=0.008), heart failure (OR, 1.5; 95% CI: 1.0‑2.2; P=0.050) and cardiac thrombus (OR, 2.0; 95% CI: 1.3‑3.1; P=0.005). Age was a significant predictor, with patients aged 65 years or younger having an OR of 2.3 (95% CI: 1.5‑3.5, P=0.002). In conclusion, the present study provides valuable insights into the impact of vascular risk factors on the outcomes of MT in patients with stroke with LVO and highlights key predictors of post‑procedural complications, including structural epilepsy and hemorrhagic transformation.
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Figure 1

Distribution of thrombectomy
techniques performed.
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Copy and paste a formatted citation
Spandidos Publications style
Aldarwish WA, Bashir S, Mohammed Ali E and Alenzi B: Impact of vascular risk factors on endovascular mechanical thrombectomy outcomes in patients with stroke. Biomed Rep 23: 168, 2025.
APA
Aldarwish, W.A., Bashir, S., Mohammed Ali, E., & Alenzi, B. (2025). Impact of vascular risk factors on endovascular mechanical thrombectomy outcomes in patients with stroke. Biomedical Reports, 23, 168. https://doi.org/10.3892/br.2025.2046
MLA
Aldarwish, W. A., Bashir, S., Mohammed Ali, E., Alenzi, B."Impact of vascular risk factors on endovascular mechanical thrombectomy outcomes in patients with stroke". Biomedical Reports 23.5 (2025): 168.
Chicago
Aldarwish, W. A., Bashir, S., Mohammed Ali, E., Alenzi, B."Impact of vascular risk factors on endovascular mechanical thrombectomy outcomes in patients with stroke". Biomedical Reports 23, no. 5 (2025): 168. https://doi.org/10.3892/br.2025.2046
Copy and paste a formatted citation
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Spandidos Publications style
Aldarwish WA, Bashir S, Mohammed Ali E and Alenzi B: Impact of vascular risk factors on endovascular mechanical thrombectomy outcomes in patients with stroke. Biomed Rep 23: 168, 2025.
APA
Aldarwish, W.A., Bashir, S., Mohammed Ali, E., & Alenzi, B. (2025). Impact of vascular risk factors on endovascular mechanical thrombectomy outcomes in patients with stroke. Biomedical Reports, 23, 168. https://doi.org/10.3892/br.2025.2046
MLA
Aldarwish, W. A., Bashir, S., Mohammed Ali, E., Alenzi, B."Impact of vascular risk factors on endovascular mechanical thrombectomy outcomes in patients with stroke". Biomedical Reports 23.5 (2025): 168.
Chicago
Aldarwish, W. A., Bashir, S., Mohammed Ali, E., Alenzi, B."Impact of vascular risk factors on endovascular mechanical thrombectomy outcomes in patients with stroke". Biomedical Reports 23, no. 5 (2025): 168. https://doi.org/10.3892/br.2025.2046
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