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Hyperthyroidism with reference to elevated serum FT3 and FT4 levels in patients with ischemic stroke

  • Authors:
    • Xianjing Zhang
    • Honghu Wu
    • Gaofeng Wang
    • Bei Chen
    • Chen Zhao
    • Changsong Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Science and Technology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China, Outpatient Department, Kunshan Affiliated Hospital of Nanjing University of Chinese Medicine, Suzhou, Jiangsu 215300, P.R. China, Department of Laboratory Medicine, Suzhou Hospital, Affiliated Hospital of Medical School, Nanjing University, Suzhou, Jiangsu 215153, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 174
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    Published online on: September 10, 2025
       https://doi.org/10.3892/br.2025.2052
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Abstract

Ischemic stroke and hyperthyroidism are common diseases and may be associated with each other. The aim of the present study was to investigate whether patients with hyperthyroidism are at risk of developing ischemic stroke, whilst also exploring biochemical metabolism biomarkers and pathophysiological features. A total of 4,674 participants diagnosed with ischemic stroke were studied by retrospective analysis, of whom 4,092 cases had normal thyroid function (control group) and 582 cases were complicated with hyperthyroidism (hyperthyroidism group). Single‑factor analysis and logistic regression analysis were applied to compare clinical parameters between patients with ischemic stroke with and without hyperthyroidism. The median serum levels of triiodothyronine (FT3), free thyroxine (FT4), cholesterol (CHO), and high‑density lipoprotein (HDL) were significantly higher in hyperthyroidism group than control group; low‑density lipoprotein (LDL) was higher in control group. Logistic regression analysis revealed that sex, age, FT3, FT4, lactate dehydrogenase and HDL were associated with ischemic stroke. Compared with those in the control group, the levels of CHO, LDL, HDL and lipoprotein in patients with hyperthyroidism were lower. Higher levels of serum FT3 [odds ratio (OR) 2.097, 95% CI, 1.795‑2.499] and FT4 (OR, 1.503; 95% CI, 1.101‑2.051) may lead to an elevated risk of ischemic stroke, compared with HDL (OR, 0.330; 95% CI, 0.194‑0.561). Therefore, these results suggested that elevated levels of serum FT3 and FT4 were associated with increased risk for ischemic stroke. In conclusion, thyroid hormones may serve different roles based on age and may aggravate the cerebral infarction injury and worsen the prognosis of patients with hyperthyroidism. 
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Copy and paste a formatted citation
Spandidos Publications style
Zhang X, Wu H, Wang G, Chen B, Zhao C and Zhang C: Hyperthyroidism with reference to elevated serum FT3 and FT4 levels in patients with ischemic stroke. Biomed Rep 23: 174, 2025.
APA
Zhang, X., Wu, H., Wang, G., Chen, B., Zhao, C., & Zhang, C. (2025). Hyperthyroidism with reference to elevated serum FT3 and FT4 levels in patients with ischemic stroke. Biomedical Reports, 23, 174. https://doi.org/10.3892/br.2025.2052
MLA
Zhang, X., Wu, H., Wang, G., Chen, B., Zhao, C., Zhang, C."Hyperthyroidism with reference to elevated serum FT3 and FT4 levels in patients with ischemic stroke". Biomedical Reports 23.5 (2025): 174.
Chicago
Zhang, X., Wu, H., Wang, G., Chen, B., Zhao, C., Zhang, C."Hyperthyroidism with reference to elevated serum FT3 and FT4 levels in patients with ischemic stroke". Biomedical Reports 23, no. 5 (2025): 174. https://doi.org/10.3892/br.2025.2052
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang X, Wu H, Wang G, Chen B, Zhao C and Zhang C: Hyperthyroidism with reference to elevated serum FT3 and FT4 levels in patients with ischemic stroke. Biomed Rep 23: 174, 2025.
APA
Zhang, X., Wu, H., Wang, G., Chen, B., Zhao, C., & Zhang, C. (2025). Hyperthyroidism with reference to elevated serum FT3 and FT4 levels in patients with ischemic stroke. Biomedical Reports, 23, 174. https://doi.org/10.3892/br.2025.2052
MLA
Zhang, X., Wu, H., Wang, G., Chen, B., Zhao, C., Zhang, C."Hyperthyroidism with reference to elevated serum FT3 and FT4 levels in patients with ischemic stroke". Biomedical Reports 23.5 (2025): 174.
Chicago
Zhang, X., Wu, H., Wang, G., Chen, B., Zhao, C., Zhang, C."Hyperthyroidism with reference to elevated serum FT3 and FT4 levels in patients with ischemic stroke". Biomedical Reports 23, no. 5 (2025): 174. https://doi.org/10.3892/br.2025.2052
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