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Biomedical Reports
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Print ISSN: 2049-9434 Online ISSN: 2049-9442
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May-2026 Volume 24 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Review Open Access

Mechanisms of monosodium urate crystal‑induced bone destruction in gouty arthritis (Review)

  • Authors:
    • Liekui Hu
    • Huizhen Li
    • Xin Huang
    • Weikang Sun
    • Qipeng Yuan
    • Huanan Li

  • View Affiliations / Copyright

    Affiliations: College of Clinical Medicine, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi 330004, P.R. China, Experimental Animal Science and Technology Center of Jiangxi University of Chinese Medicine, Nanchang, Jiangxi 330004, P.R. China, Department of Scientific Research, Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang, Jiangxi 330025, P.R. China
    Copyright: © Hu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 61
    |
    Published online on: March 23, 2026
       https://doi.org/10.3892/br.2026.2134
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Abstract

The deformities and disabilities resulting from bone destruction in gouty arthritis impose substantial physical and psychological burdens on patients, underscoring the urgent need to elucidate the mechanisms underlying gout‑induced osteolysis. Monosodium urate (MSU) crystals play a central role in the pathogenesis of bone destruction in gouty arthritis, significantly disrupting the activity and function of bone‑related cells. Mechanistically, MSU induces bone loss by triggering oxidative stress, amplifying inflammatory cascades, and dysregulating bone remodeling pathways. Understanding these pathological mechanisms is essential for early clinical intervention and the development of targeted therapies to prevent disease progression. The present review systematically examines the multifaceted impact of MSU on bone homeostasis and its molecular interactions in gouty arthritis‑associated bone destruction, providing insights to refine diagnostic strategies and advance novel therapeutic approaches.

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Copy and paste a formatted citation
Spandidos Publications style
Hu L, Li H, Huang X, Sun W, Yuan Q and Li H: Mechanisms of monosodium urate crystal‑induced bone destruction in gouty arthritis (Review). Biomed Rep 24: 61, 2026.
APA
Hu, L., Li, H., Huang, X., Sun, W., Yuan, Q., & Li, H. (2026). Mechanisms of monosodium urate crystal‑induced bone destruction in gouty arthritis (Review). Biomedical Reports, 24, 61. https://doi.org/10.3892/br.2026.2134
MLA
Hu, L., Li, H., Huang, X., Sun, W., Yuan, Q., Li, H."Mechanisms of monosodium urate crystal‑induced bone destruction in gouty arthritis (Review)". Biomedical Reports 24.5 (2026): 61.
Chicago
Hu, L., Li, H., Huang, X., Sun, W., Yuan, Q., Li, H."Mechanisms of monosodium urate crystal‑induced bone destruction in gouty arthritis (Review)". Biomedical Reports 24, no. 5 (2026): 61. https://doi.org/10.3892/br.2026.2134
Copy and paste a formatted citation
x
Spandidos Publications style
Hu L, Li H, Huang X, Sun W, Yuan Q and Li H: Mechanisms of monosodium urate crystal‑induced bone destruction in gouty arthritis (Review). Biomed Rep 24: 61, 2026.
APA
Hu, L., Li, H., Huang, X., Sun, W., Yuan, Q., & Li, H. (2026). Mechanisms of monosodium urate crystal‑induced bone destruction in gouty arthritis (Review). Biomedical Reports, 24, 61. https://doi.org/10.3892/br.2026.2134
MLA
Hu, L., Li, H., Huang, X., Sun, W., Yuan, Q., Li, H."Mechanisms of monosodium urate crystal‑induced bone destruction in gouty arthritis (Review)". Biomedical Reports 24.5 (2026): 61.
Chicago
Hu, L., Li, H., Huang, X., Sun, W., Yuan, Q., Li, H."Mechanisms of monosodium urate crystal‑induced bone destruction in gouty arthritis (Review)". Biomedical Reports 24, no. 5 (2026): 61. https://doi.org/10.3892/br.2026.2134
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