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Biomedical Reports
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Print ISSN: 2049-9434 Online ISSN: 2049-9442
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May-2026 Volume 24 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Review Open Access

Syntaxin1A in synaptopathies: From molecular mechanisms to therapeutic implications in neurological disorders (Review)

  • Authors:
    • Yating Huang
    • Jun Xi
    • Baoling Su
    • Peipei Wang
    • Cuimei Xie
    • Yifan Yuan
    • Xiaoping Yin
    • Bing Bao

  • View Affiliations / Copyright

    Affiliations: Department of Neurology, College of First Clinical Medical Science, Gannan Medical University, Ganzhou, Jiangxi 341000, P.R. China, Department of Neurology, College of Clinical Medical Science, Jiujiang University, Jiujiang, Jiangxi 332000, P.R. China, Department of Neurology, University of Shanghai for Science and Technology, Shanghai 200000, P.R. China, Department of Neurology, Affiliated Hospital of Jiujiang University, Jiujiang, Jiangxi 332000, P.R. China
    Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 65
    |
    Published online on: March 26, 2026
       https://doi.org/10.3892/br.2026.2138
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Abstract

Syntaxin1A (STX1A) is a presynaptic membrane protein that is abundantly expressed in the central nervous system. It is a key member of the soluble N‑ethylmaleimide sensitive factor attachment protein receptor protein family. Notably, STX1A acts as a ‘molecular hub’ in neural networks by regulating presynaptic membrane fusion with synaptic vesicles and the subsequent release of neurotransmitters. In addition to this function, STX1A is crucial for neuronal development, synaptic plasticity, and ion channel regulation. The deficiency or variation of STX1A not only directly disrupts neurotransmitter transmission but also contributes to pathological processes in neurological disorders such as Alzheimer's disease, epilepsy, autism spectrum disorder, and ischemic stroke by interfering with excitatory‑inhibitory balance, inducing neuroinflammation, and triggering neuronal apoptosis. The present review summarizes the structure and physiological functions of STX1A, highlights its mechanisms in the pathogenesis of various neurological diseases, and examines its potential as a diagnostic biomarker and therapeutic target for these diseases.

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Copy and paste a formatted citation
Spandidos Publications style
Huang Y, Xi J, Su B, Wang P, Xie C, Yuan Y, Yin X and Bao B: Syntaxin1A in synaptopathies: From molecular mechanisms to therapeutic implications in neurological disorders (Review). Biomed Rep 24: 65, 2026.
APA
Huang, Y., Xi, J., Su, B., Wang, P., Xie, C., Yuan, Y. ... Bao, B. (2026). Syntaxin1A in synaptopathies: From molecular mechanisms to therapeutic implications in neurological disorders (Review). Biomedical Reports, 24, 65. https://doi.org/10.3892/br.2026.2138
MLA
Huang, Y., Xi, J., Su, B., Wang, P., Xie, C., Yuan, Y., Yin, X., Bao, B."Syntaxin1A in synaptopathies: From molecular mechanisms to therapeutic implications in neurological disorders (Review)". Biomedical Reports 24.5 (2026): 65.
Chicago
Huang, Y., Xi, J., Su, B., Wang, P., Xie, C., Yuan, Y., Yin, X., Bao, B."Syntaxin1A in synaptopathies: From molecular mechanisms to therapeutic implications in neurological disorders (Review)". Biomedical Reports 24, no. 5 (2026): 65. https://doi.org/10.3892/br.2026.2138
Copy and paste a formatted citation
x
Spandidos Publications style
Huang Y, Xi J, Su B, Wang P, Xie C, Yuan Y, Yin X and Bao B: Syntaxin1A in synaptopathies: From molecular mechanisms to therapeutic implications in neurological disorders (Review). Biomed Rep 24: 65, 2026.
APA
Huang, Y., Xi, J., Su, B., Wang, P., Xie, C., Yuan, Y. ... Bao, B. (2026). Syntaxin1A in synaptopathies: From molecular mechanisms to therapeutic implications in neurological disorders (Review). Biomedical Reports, 24, 65. https://doi.org/10.3892/br.2026.2138
MLA
Huang, Y., Xi, J., Su, B., Wang, P., Xie, C., Yuan, Y., Yin, X., Bao, B."Syntaxin1A in synaptopathies: From molecular mechanisms to therapeutic implications in neurological disorders (Review)". Biomedical Reports 24.5 (2026): 65.
Chicago
Huang, Y., Xi, J., Su, B., Wang, P., Xie, C., Yuan, Y., Yin, X., Bao, B."Syntaxin1A in synaptopathies: From molecular mechanisms to therapeutic implications in neurological disorders (Review)". Biomedical Reports 24, no. 5 (2026): 65. https://doi.org/10.3892/br.2026.2138
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