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Platelet‑rich plasma in the management of diabetic foot ulcers (Review)

  • Authors:
    • Andrei-Alexandru Tomac
    • Cătălin Mircea Coșarcă
    • Cristian Trâmbițaș
    • Dorin Constantin Dorobanțu
    • Mihaela Pertea
    • Raluca Tilinca
    • Cosmin Carasca
    • Gergo Raduly
    • Maria Gabriela Rezmuves
    • Mariana Cornelia Tilinca
  • View Affiliations / Copyright

    Affiliations: Doctoral School of Medicine and Pharmacy, ‘George Emil Palade’ University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540139 Targu Mures, Romania, Department of Vascular Surgery, Mures County Emergency Hospital, 540136 Targu Mures, Romania, Department of Plastic Surgery, Mures County Emergency Hospital, 540136 Targu Mures, Romania, Department of Plastic Surgery, ‘Saint Spiridon’ Emergency Clinical Hospital, 700111 Iasi, Romania, Clinic of Epidemiology, Mures County Hospital, 540139 Targu Mures, Romania, Department of Forensic Medicine, ‘George Emil Palade’ University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540139 Targu Mures, Romania, Department of Anesthesiology and Intensive Care, Mures County Emergency Hospital, 540136 Targu Mures, Romania, Department of Diabetes, Nutrition and Metabolic Diseases, Mures County Emergency Hospital, 540136 Targu Mures, Romania
    Copyright: © Tomac et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 69
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    Published online on: April 2, 2026
       https://doi.org/10.3892/br.2026.2142
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Abstract

Diabetes mellitus represents a major global health concern, frequently complicated by chronic, non‑healing wounds such as diabetic foot ulcers (DFUs). These ulcers are a leading cause of morbidity, impaired quality of life and limb amputation among individuals with diabetes. The impaired healing capacity observed in DFUs results from persistent inflammation, ischemia and a deficiency of local growth factors, which together hinder effective tissue regeneration. Platelet‑rich plasma (PRP), an autologous or allogeneic concentrate of platelets, fibrin, cytokines and leukocytes, has been proposed as a biologically active adjunct capable of accelerating tissue regeneration. The present study performed a narrative review of clinical trials and comparative studies assessing PRP therapy compared with the standard of care (SOC) in the treatment of DFUs. Across the reviewed literature, PRP demonstrated higher complete healing rates and a shorter time‑to‑closure compared with the SOC. In addition, a reduction in infection rates, pain intensity and ulcer recurrence was consistently reported, with minimal adverse effects. Both autologous and allogeneic PRP preparations were effective, and no major difference was observed between topical application and perilesional injection. In conclusion, PRP therapy represents a safe and promising option for enhancing wound healing in patients with DFUs. However, the lack of standardized preparation protocols and heterogeneous study methodologies underscores the need for well‑designed, multicenter randomized trials to confirm these findings and to establish optimal treatment parameters.
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Tomac A, Coșarcă CM, Trâmbițaș C, Dorobanțu DC, Pertea M, Tilinca R, Carasca C, Raduly G, Rezmuves MG, Tilinca MC, Tilinca MC, et al: Platelet‑rich plasma in the management of diabetic foot ulcers (Review). Biomed Rep 24: 69, 2026.
APA
Tomac, A., Coșarcă, C.M., Trâmbițaș, C., Dorobanțu, D.C., Pertea, M., Tilinca, R. ... Tilinca, M.C. (2026). Platelet‑rich plasma in the management of diabetic foot ulcers (Review). Biomedical Reports, 24, 69. https://doi.org/10.3892/br.2026.2142
MLA
Tomac, A., Coșarcă, C. M., Trâmbițaș, C., Dorobanțu, D. C., Pertea, M., Tilinca, R., Carasca, C., Raduly, G., Rezmuves, M. G., Tilinca, M. C."Platelet‑rich plasma in the management of diabetic foot ulcers (Review)". Biomedical Reports 24.6 (2026): 69.
Chicago
Tomac, A., Coșarcă, C. M., Trâmbițaș, C., Dorobanțu, D. C., Pertea, M., Tilinca, R., Carasca, C., Raduly, G., Rezmuves, M. G., Tilinca, M. C."Platelet‑rich plasma in the management of diabetic foot ulcers (Review)". Biomedical Reports 24, no. 6 (2026): 69. https://doi.org/10.3892/br.2026.2142
Copy and paste a formatted citation
x
Spandidos Publications style
Tomac A, Coșarcă CM, Trâmbițaș C, Dorobanțu DC, Pertea M, Tilinca R, Carasca C, Raduly G, Rezmuves MG, Tilinca MC, Tilinca MC, et al: Platelet‑rich plasma in the management of diabetic foot ulcers (Review). Biomed Rep 24: 69, 2026.
APA
Tomac, A., Coșarcă, C.M., Trâmbițaș, C., Dorobanțu, D.C., Pertea, M., Tilinca, R. ... Tilinca, M.C. (2026). Platelet‑rich plasma in the management of diabetic foot ulcers (Review). Biomedical Reports, 24, 69. https://doi.org/10.3892/br.2026.2142
MLA
Tomac, A., Coșarcă, C. M., Trâmbițaș, C., Dorobanțu, D. C., Pertea, M., Tilinca, R., Carasca, C., Raduly, G., Rezmuves, M. G., Tilinca, M. C."Platelet‑rich plasma in the management of diabetic foot ulcers (Review)". Biomedical Reports 24.6 (2026): 69.
Chicago
Tomac, A., Coșarcă, C. M., Trâmbițaș, C., Dorobanțu, D. C., Pertea, M., Tilinca, R., Carasca, C., Raduly, G., Rezmuves, M. G., Tilinca, M. C."Platelet‑rich plasma in the management of diabetic foot ulcers (Review)". Biomedical Reports 24, no. 6 (2026): 69. https://doi.org/10.3892/br.2026.2142
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