|
1
|
Kalluri R and LeBleu VS: The biology,
function, and biomedical applications of exosomes. Science.
367(eaau6977)2020.PubMed/NCBI View Article : Google Scholar
|
|
2
|
van Niel G, D'Angelo G and Raposo G:
Shedding light on the cell biology of extracellular vesicles. Nat
Rev Mol Cell Biol. 19:213–228. 2018.PubMed/NCBI View Article : Google Scholar
|
|
3
|
Zeng YB, Deng X, Shen LS, Yang Y, Zhou X,
Ye L, Chen S, Yang DJ and Chen GQ: Advances in plant-derived
extracellular vesicles: Isolation, composition, and biological
functions. Food Funct. 15:11319–11341. 2024.PubMed/NCBI View Article : Google Scholar
|
|
4
|
Lian MQ, Chng WH, Liang J, Yeo HQ, Lee CK,
Belaid M, Tollemeto M, Wacker MG, Czarny B and Pastorin G:
Plant-derived extracellular vesicles: Recent advancements and
current challenges on their use for biomedical applications. J
Extracell Vesicles. 11(e12283)2022.PubMed/NCBI View Article : Google Scholar
|
|
5
|
Zhu Y, Zhao J, Ding H, Qiu M, Xue L, Ge D,
Wen G, Ren H, Li P and Wang J: Applications of plant-derived
extracellular vesicles in medicine. MedComm (2020).
5(e741)2024.PubMed/NCBI View
Article : Google Scholar
|
|
6
|
Global Biodiversity Information Facility
(GBIF): Talinum fruticosum (L.) Juss. Available: https://www.gbif.org/species/3084670.
Accessed September 19, 2025.
|
|
7
|
Manikandan K, Balaji T and Dhanushkodi V:
Talinum fruticosum: A potential multi-value plant: A review.
Agric Rev. 46:416–422. 2025.
|
|
8
|
Dinesh A and Kumar A: A review on
bioactive compounds, ethnomedicinal importance and pharmacological
activities of Talinum triangulare (Jacq.) Willd. Chem
Biodivers. 20(e202301079)2023.PubMed/NCBI View Article : Google Scholar
|
|
9
|
Barman D, Puro KN, Boruah JLH, Kumar D,
Medhi K, Mazumder B and Baishya R: Talinum triangulare
(Jacq.) Willd: A review of its traditional uses, phytochemistry,
and pharmacology along with network pharmacology analysis of its
components and targets. Food Chem Adv. 5(100768)2024.
|
|
10
|
Plants of the World Online (POWO):
Talinum fruticosum (L.) Juss. Available: https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:1182764-2.
Accessed September 19, 2025.
|
|
11
|
Flora of North America (FNA): Talinum
fruticosum. Available: http://floranorthamerica.org/Talinum_fruticosum.
Accessed September 19, 2025.
|
|
12
|
Inwang UA, Ben EE, Uchewa OO, Nwuzor EO,
Nwaji AR and Umoh EA: Anti-oxidant and anti-inflammatory properties
of Talinum triangulare methanol leaf extract on
cadmium-induced cognitive dysfunction in male wistar rat. Nat Prod
Commun. 19:1–10. 2024.
|
|
13
|
Oladele JO, Ojuederie OB, Oladele OT,
Ajayi EIO, Olaniyan MD, Atolagbe OS, Okoro OE, Adewale OO and
Oyeleke OM: Gastroprotective mechanism of Talinum
triangulare on ethanol-induced gastric ulcer in Wistar rats via
inflammatory, antioxidant, and H+/K+-ATPase
inhibition-mediated pathways. Drug Chem Toxicol. 48:281–293.
2025.PubMed/NCBI View Article : Google Scholar
|
|
14
|
Global Biodiversity Information Facility
(GBIF): Talinum paniculatum Moench. Available: https://www.gbif.org/species/7906855.
Accessed September 19, 2025.
|
|
15
|
Souto CGRG, Lorençone BR, Marques AAM,
Palozi RAC, Romão PVM, Guarnier LP, Tirloni CAS, Dos Santos AC,
Souza RIC, Zago PMJJ, et al: Cardioprotective effects of Talinum
paniculatum (Jacq.) Gaertn. in doxorubicin-induced
cardiotoxicity in hypertensive rats. J Ethnopharmacol.
281(114568)2021.PubMed/NCBI View Article : Google Scholar
|
|
16
|
Miyagi S, Iwama N, Kawabata T and Hasegawa
K: Longevity and diet in Okinawa, Japan: The past, present and
future. Asia Pac J Public Health. 15 (Suppl 1):S3–S9.
2003.PubMed/NCBI View Article : Google Scholar
|
|
17
|
Willcox BJ, Willcox DC, Todoriki H,
Fujiyoshi A, Yano K, He Q, Curb JD and Suzuki M: Caloric
restriction, the traditional Okinawan diet, and healthy aging: The
diet of the world's longest-lived people and its potential impact
on morbidity and life span. Ann NY Acad Sci. 1114:434–455.
2007.PubMed/NCBI View Article : Google Scholar
|
|
18
|
Willcox DC, Willcox BJ, Todoriki H and
Suzuki M: The Okinawan diet: Health implications of a low-calorie,
nutrient-dense, antioxidant-rich dietary pattern low in glycemic
load. J Am Coll Nutr. 28 (Suppl 1):500S–516S. 2009.PubMed/NCBI View Article : Google Scholar
|
|
19
|
Willcox DC, Scapagnini G and Willcox BJ:
Healthy aging diets other than the Mediterranean: A focus on the
Okinawan diet. Mech Ageing Dev. 136-137:148–162. 2014.PubMed/NCBI View Article : Google Scholar
|
|
20
|
Subtropical Plant Resources Database,
University of the Ryukyus: Talinum paniculatum Gaertn.
Available: https://iicc.skr.u-ryukyu.ac.jp/plant/br/720.php.
Accessed September 19, 2025.
|
|
21
|
Kim J, Li S, Zhang S and Wang J:
Plant-derived exosome-like nanoparticles and their therapeutic
activities. Asian J Pharm Sci. 17:53–69. 2022.PubMed/NCBI View Article : Google Scholar
|
|
22
|
López-López S, Castro-Robles B,
García-Flores N, Díaz-Guerra MJM, Arias-Salazar L, Sandoval H,
García-Pérez D, Klein-Zampaña CJ, Barbella-Aponte RA, Segura T and
Serrano-Heras G: Proinflammatory macrophage secretome enhances
temozolomide sensitivity in glioblastoma via pSTAT3-mediated
downregulation of DNA repair enzymes. Sci Rep.
15(38875)2025.PubMed/NCBI View Article : Google Scholar
|
|
23
|
Li R, Shen Q, Wu N, He M, Liu N, Huang J,
Lu B, Yao Q, Yang Y and Hu R: MiR-145 improves macrophage-mediated
inflammation through targeting Arf6. Endocrine. 60:73–82.
2018.PubMed/NCBI View Article : Google Scholar
|
|
24
|
Kishimoto T and Kang S: IL-6 revisited:
From rheumatoid arthritis to CAR T cell therapy and COVID-19. Annu
Rev Immunol. 40:323–348. 2022.PubMed/NCBI View Article : Google Scholar
|
|
25
|
Favalli EG: Understanding the role of
interleukin-6 (IL-6) in the joint and beyond: A comprehensive
review of IL-6 inhibition for the management of rheumatoid
arthritis. Rheumatol Ther. 7:473–516. 2020.PubMed/NCBI View Article : Google Scholar
|
|
26
|
Pattanaik SS, Panda AK, Pati A, Padhi S,
Tripathy R, Tripathy SR, Parida MK and Das BK: Role of
interleukin-6 and interferon-α in systemic lupus erythematosus: A
case-control study and meta-analysis. Lupus. 31:1094–1103.
2022.PubMed/NCBI View Article : Google Scholar
|
|
27
|
Choy EH, De Benedetti F, Takeuchi T,
Hashizume M, John MR and Kishimoto T: Translating IL-6 biology into
effective treatments. Nat Rev Rheumatol. 16:335–345.
2020.PubMed/NCBI View Article : Google Scholar
|
|
28
|
Mazzoni A, Salvati L, Maggi L, Capone M,
Vanni A, Spinicci M, Mencarini J, Caporale R, Peruzzi B, Antonelli
A, et al: Impaired immune cell cytotoxicity in severe COVID-19 is
IL-6 dependent. J Clin Invest. 130:4694–4703. 2020.PubMed/NCBI View Article : Google Scholar
|
|
29
|
Liu Y and Chen L: Impact of interleukin 6
levels on acute lung injury risk and disease severity in critically
ill sepsis patients. World J Clin Cases. 12:5374–5381.
2024.PubMed/NCBI View Article : Google Scholar
|
|
30
|
Sheridan R, Brennan K, Bazou D, O'Gorman
P, Matallanas D and Mc Gee MM: Multiple myeloma derived
extracellular vesicle uptake by monocyte cells stimulates IL-6 and
MMP-9 secretion and promotes cancer cell migration and
proliferation. Cancers (Basel). 16(1011)2024.PubMed/NCBI View Article : Google Scholar
|
|
31
|
Hu Y, Chen H, Jin L, Chi X, Zhao J and Cao
Q: Hypomethylation of IL6ST promotes development of endometriosis
by activating JAK2/STAT3 signaling pathway. PLoS One.
20(e0317569)2025.PubMed/NCBI View Article : Google Scholar
|
|
32
|
Aletaha D, Kerschbaumer A, Kastrati K,
Dejaco C, Dougados M, McInnes IB, Sattar N, Stamm TA, Takeuchi T,
Trauner M, et al: Consensus statement on blocking interleukin-6
receptor and interleukin-6 in inflammatory conditions: An update.
Ann Rheum Dis. 82:773–787. 2023.PubMed/NCBI View Article : Google Scholar
|
|
33
|
Hu J, Sun Y, Zuo X and Zou Y: Assessment
of adverse events related to anti-interleukin-6 receptor monoclonal
antibodies using the FDA adverse event reporting system: A
real-world pharmacovigilance study. Expert Opin Drug Saf.
23:1327–1339. 2024.PubMed/NCBI View Article : Google Scholar
|
|
34
|
Ambrosone A, Barbulova A, Cappetta E,
Cillo F, De Palma M, Ruocco M and Pocsfalvi G: Plant extracellular
vesicles: Current landscape and future directions. Plants (Basel).
12(4141)2023.PubMed/NCBI View Article : Google Scholar
|
|
35
|
Xu Z, Xu Y, Zhang K, Liu Y, Liang Q,
Thakur A, Liu W and Yan Y: Plant-derived extracellular vesicles
(PDEVs) in nanomedicine for human disease and therapeutic
modalities. J Nanobiotechnology. 21(114)2023.PubMed/NCBI View Article : Google Scholar
|
|
36
|
Li C, Zeng A, Li L and Zhao W: Emerging
roles of plant-derived extracellular vesicles in biotherapeutics:
Advances, applications, and future perspectives. Adv Biol (Weinh).
9(e2500008)2025.PubMed/NCBI View Article : Google Scholar
|
|
37
|
Emmanuela N, Muhammad DR, Iriawati Wijaya
CH, Ratnadewi YMD, Takemori H, Ana ID, Yuniati R, Handayani W,
Wungu TDK, et al: Isolation of plant-derived exosome-like
nanoparticles (PDENs) from Solanum nigrum L. berries and
their effect on interleukin-6 expression as a potential
anti-inflammatory agent. PLoS One. 19(e0296259)2024.PubMed/NCBI View Article : Google Scholar
|
|
38
|
Song Y, Feng N, Yu Q, Li Y, Meng M, Yang
X, Gan Z, Xu T, Tang C and Zhang Y: Exosomes in disease therapy:
plant-derived exosome-like nanoparticles current status,
challenges, and future prospects. Int J Nanomedicine.
20:10613–10644. 2025.PubMed/NCBI View Article : Google Scholar
|
|
39
|
Chi J, Wang X, Song Y, Wang J, Guo L, Wang
R and Wang G: Emerging plant-derived exosome-like particles reveal
key therapeutic benefits. A comprehensive review of evidence. Int J
Nanomedicine. 20:12393–12411. 2025.PubMed/NCBI View Article : Google Scholar
|