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Relationship between remission rate of type 2 diabetes and skeletal muscle after laparoscopic sleeve gastrectomy

  • Authors:
    • Hironobu Takano
    • Yuma Ebihara
    • Yuki Oe
    • Hideyuki Wada
    • Takeo Nitta
    • Akinobu Nakamura
    • Toshiaki Shichinohe
    • Satoshi Hirano
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterological Surgery II, Hokkaido University Hospital, Sapporo, Hokkaido 060‑8638, Japan, Department of Rheumatology, Endocrinology and Nephrology, Hokkaido University Hospital, Sapporo, Hokkaido 060‑8638, Japan
    Copyright: © Takano et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 79
    |
    Published online on: April 29, 2026
       https://doi.org/10.3892/br.2026.2152
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Abstract

Bariatric surgery can contribute to weight loss and the improvement of obesity‑related diseases. Laparoscopic sleeve gastrectomy (LSG) is among the most frequently performed procedures worldwide, including in Japan. Skeletal muscle plays an essential role in energy metabolism and whole‑body glucose homeostasis, and diabetes decreases insulin‑induced glucose uptake in skeletal muscle. The present study investigated postoperative outcomes and factors related to type 2 diabetes (T2D) remission rates in LSG cases, including skeletal muscles. This retrospective study analyzed perioperative outcomes and factors associated with T2D remission after LSG, with a particular focus on skeletal muscle mass assessed by bioelectrical impedance analysis. LSG was performed on 90 patients between October 2016 and February 2024. First, the perioperative outcomes and weight loss effects in these 90 patients were examined. Muscle or skeletal mass perioperative factors were compared between patients with and without T2D remission. At 6 months after surgery, the median total weight loss was 21%, and the median excess weight loss was 52%. The rate of remission and improvement of T2D was 75%. The group that showed T2D remission generally had a significantly higher skeletal muscle mass or percentage throughout the preoperative and postoperative period (P<0.05). The remission rate of T2D after LSG was favorable, and a relationship was observed between T2D remission after LSG, and skeletal muscle mass before and after surgery.
View Figures

Figure 1

Trends in weight and BMI and rate of
weight loss after laparoscopic sleeve gastrectomy. Values are
presented as medians. *P<0.0001. BMI, body mass
index; %TWL, total weight loss rate; %EWL, excess weight loss rate;
pre, pre-surgery; M, months.

Figure 2

Grouping of the study participants.
The participants were divided according to whether they achieved
T2D remission or not (non-remission group). T2D, type 2
diabetes.

Figure 3

Trends in muscle mass/percentage and
skeletal muscle mass/percentage after laparoscopic sleeve
gastrectomy. *P<0.05. T2D, type 2 diabetes; pre,
pre-surgery; M, months.
View References

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Copy and paste a formatted citation
Spandidos Publications style
Takano H, Ebihara Y, Oe Y, Wada H, Nitta T, Nakamura A, Shichinohe T and Hirano S: Relationship between remission rate of type 2 diabetes and skeletal muscle after laparoscopic sleeve gastrectomy. Biomed Rep 24: 79, 2026.
APA
Takano, H., Ebihara, Y., Oe, Y., Wada, H., Nitta, T., Nakamura, A. ... Hirano, S. (2026). Relationship between remission rate of type 2 diabetes and skeletal muscle after laparoscopic sleeve gastrectomy. Biomedical Reports, 24, 79. https://doi.org/10.3892/br.2026.2152
MLA
Takano, H., Ebihara, Y., Oe, Y., Wada, H., Nitta, T., Nakamura, A., Shichinohe, T., Hirano, S."Relationship between remission rate of type 2 diabetes and skeletal muscle after laparoscopic sleeve gastrectomy". Biomedical Reports 24.6 (2026): 79.
Chicago
Takano, H., Ebihara, Y., Oe, Y., Wada, H., Nitta, T., Nakamura, A., Shichinohe, T., Hirano, S."Relationship between remission rate of type 2 diabetes and skeletal muscle after laparoscopic sleeve gastrectomy". Biomedical Reports 24, no. 6 (2026): 79. https://doi.org/10.3892/br.2026.2152
Copy and paste a formatted citation
x
Spandidos Publications style
Takano H, Ebihara Y, Oe Y, Wada H, Nitta T, Nakamura A, Shichinohe T and Hirano S: Relationship between remission rate of type 2 diabetes and skeletal muscle after laparoscopic sleeve gastrectomy. Biomed Rep 24: 79, 2026.
APA
Takano, H., Ebihara, Y., Oe, Y., Wada, H., Nitta, T., Nakamura, A. ... Hirano, S. (2026). Relationship between remission rate of type 2 diabetes and skeletal muscle after laparoscopic sleeve gastrectomy. Biomedical Reports, 24, 79. https://doi.org/10.3892/br.2026.2152
MLA
Takano, H., Ebihara, Y., Oe, Y., Wada, H., Nitta, T., Nakamura, A., Shichinohe, T., Hirano, S."Relationship between remission rate of type 2 diabetes and skeletal muscle after laparoscopic sleeve gastrectomy". Biomedical Reports 24.6 (2026): 79.
Chicago
Takano, H., Ebihara, Y., Oe, Y., Wada, H., Nitta, T., Nakamura, A., Shichinohe, T., Hirano, S."Relationship between remission rate of type 2 diabetes and skeletal muscle after laparoscopic sleeve gastrectomy". Biomedical Reports 24, no. 6 (2026): 79. https://doi.org/10.3892/br.2026.2152
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