Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
November-December 2010 Volume 1 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-December 2010 Volume 1 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

High ratio of interfollicular cd8/foxp3-positive regulatory T cells is associated with a high flipi index and poor overall survival in follicular lymphoma

  • Authors:
    • Majda Saifi
    • Aurélie Maran
    • Pierre Raynaud
    • Marie Christine Picot
    • Philippe Quittet
    • Guillaume Cartron
    • Jean François Rossi
    • Valérie Costes
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, CHU Montpellier, 34295 Montpellier Cedex 5, France, Medical Information Department, CHU Montpellier, 34295 Montpellier Cedex 5, France, Onco-Hematology and Biotherapy Department, CHU Montpellier, 34295 Montpellier Cedex 5, France, INSERM U847, CHU Montpellier, 34295 Montpellier Cedex 5, France
  • Pages: 933-938
    |
    Published online on: September 1, 2010
       https://doi.org/10.3892/etm.2010.146
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Several studies have highlighted the importance of the microenvironment in the behaviour of follicular lymphoma (FL). We conducted an immunohistochemical analysis to assess the role of different cell subpopulations, i.e. CD8, CD68 and forkhead box protein P3 (FOXP3)-positive regulatory T cells (Treg cells) in 84 lymph nodes of 58 patients with FL (58 at diagnosis, 26 at relapse). Since the overall effect of Tregs is considered to depend on their number in relation to CD8+ effector T cells, we determined the corresponding ratio for each patient and correlated the results with clinical parameters. The interfollicular CD8/FOXP3+ cell ratio was significantly higher in patients with histological grade 3 tumours (2.04 vs. 1.63) and with a high risk FLIPI index (2.99 vs. 1.53) compared to those with grade 1-2 tumours or a low-intermediate FLIPI index. Similar results were obtained for the follicular CD8+/FOXP3+ cell ratio. The interfollicular CD8/FOXP3 ratio was found to have prognostic value [a 5-year overall survival (OS) of 82 vs. 59% for a ratio of ±1.68]. In addition, an interfollicular FOXP3+ cell number of more than 86 cells/mm2 was correlated with a more favourable outcome (p=0.03). When patients at diagnosis and relapse were compared, a significant difference (p=0.05) in the localization (interfollicular vs. intrafollicular) of FOXP3+ cells was observed. The CD8/FOXP3 ratio in the interfollicular areas was significantly different (1.66 at diagnosis vs. 2.2 at relapse, p=0.05). The presence of a small number of FOXP3+ cells with a high CD8/FOXP3 ratio is probably the indicator of an active immune response during tumour development, with lymphoma cells acting as targets or bystanders.
View Figures

Figure 1

Figure 2

Figure 3

View References

1. 

Tsujimoto Y, Cossman J, Jaffe E and Croce CM: Involvement of the bcl-2 gene in human follicular lymphoma. Sciences. 228:1440–1443. 1985. View Article : Google Scholar : PubMed/NCBI

2. 

Clearly ML and Sklar J: Nucleotide sequence of t(14,18) chromosomal breakpoint in follicular lymphoma and demonstration of a breakpoint-cluster region near a transcriptionally active locus on chromosome 18. Proc Natl Acad Sci USA. 82:7439–7443. 1995. View Article : Google Scholar

3. 

Solal-Céligny P, Roy P, Colombat P, White J, Armitage JO, Arranz-Saez R, Au WY, Bellei M, Brice P, Caballero D, Coiffier B, Conde-Garcia E, Doyen C, Federico M, Fisher RI, Garcia-Conde JF, Guglielmi C, Hagenbeek A, Haïoun C, LeBlanc M, Lister AT, Lopez-Guillermo A, McLaughlin P, Milpied N, Morel P, Mounier N, Proctor SJ, Rohatiner A, Smith P, Soubeyran P, Tilly H, Vitolo U, Zinzani PL, Zucca E and Montserrat E: Follicular Lymphoma International Prognostic Index. Blood. 104:1258–1265. 2004.

4. 

Lossos IS and Levy R: Higher-grade transformation of follicle center lymphoma is associated with somatic mutation of 5′ noncoding regulatory region of Bcl-6 gene. Blood. 96:635–639. 2000.

5. 

Küppers R: Prognosis in follicular lymphoma – it’s in the microenvironment. N Engl J Med. 351:2152–2153. 2004.

6. 

Natkunam Y: The biology of germinal center. Hemat Am Soc Hematol Educ Program. 210–215. 2007. View Article : Google Scholar

7. 

Amé-Thomas P, Maby-El Hajjami H, Monvoisin C, Jean R, Monnier D, Caulet-Maugendre S, Guillaudeeux T, Lamy T, Fest T and Tarte K: Human mesenchymal stem cells isolated from bone marrow and lymphoid organs support tumor B-cell growth: role of stromal cells in follicular lymphoma pathogenesis. Blood. 109:693–702. 2007.PubMed/NCBI

8. 

Herreros B, Sanchez-Aguilera A and Piris MA: Lymphoma microenvironment: culprit or innocent. Leukemia. 22:49–58. 2008. View Article : Google Scholar : PubMed/NCBI

9. 

Carbone A, Gloghini A, Cabras A and Elia G: Differentiating germinal center-derived lymphomas through their cellular microenvironment. Am J Haematol. 84:435–438. 2009. View Article : Google Scholar : PubMed/NCBI

10. 

Staudt LM and Dave S: The biology of human lymphoid malignancies revealed by gene expression profiling. Adv Immunol. 87:163–208. 2005. View Article : Google Scholar : PubMed/NCBI

11. 

Dave SS, Wright G, Tan B, Rosenwald A, Gascoyne RD, Chan WC, Fisher RI, Braziel RM, Rimsza LM, Grogan TM, Miller TP, LeBlanc M, Greiner TC, Weisenburger DD, Lynch JC, Vose J, Armitage JO, Smeland EB, Kvaloy S, Holte H, Delabie J, Connors JM, Lansdorp PM, Ouyang Q, Lister TA, Davies AJ, Norton AJ, Muller-Hermelink HK, Ott G, Campo E, Montserrat E, Wilson WH, Jaffe ES, Simon R, Yang L, Powell J, Zhao H, Goldschmidt N, Chiorazzi M and Staudt LM: Prediction of survival in follicular lymphoma based on molecular features of tumor-infiltrating immune cells. N Engl J Med. 351:2159–2169. 2004. View Article : Google Scholar : PubMed/NCBI

12. 

Woo EY, Chu CS, Goletz TJ, et al: Regulatory CD4+ CD25+ T cells in tumors from patients with early-stage non-small cell lung cancer and late-stage ovarian cancer. Cancer Res. 61:4766–4772. 2001.PubMed/NCBI

13. 

Shevach EM: Mechanisms of foxp3+ T regulatory cell-mediated suppression. Immunity. 30:636–645. 2009.

14. 

Farinha P, Al-Tourah A, Gill K, Klasa R, Connors JM and Gascoyne RD: The architectural pattern of FOXP3-positive T cells in follicular lymphoma is an independent predictor of survival and histologic transformation. Blood. 115:289–295. 2010. View Article : Google Scholar : PubMed/NCBI

15. 

Lee AM, Clear AJ, Calaminici M, Davies AJ, Jordan S, MacDougall F, Matthews J, Norton AJ, Gribben JG, Lister TA and Goff LK: Numbers of CD4+ cells and location of forkhead box protein-P3-positive cells in diagnostic follicular lymphoma tissue microarrays correlates with outcome. J Clin Oncol. 24:5052–5059. 2006.

16. 

Tzankov A, Meier C, Hirschmann P, Went P, Pileri SA and Dirnhofer S: Correlation of high numbers of intratumoral FoxP3 regulatory T cells with improved survival in germinal center-like diffuse large B-cell lymphoma, follicular lymphoma and classical Hodgkin’s lymphoma. Haematologica. 93:193–200. 2008.PubMed/NCBI

17. 

Carreras J, Lopez-Guillermo A, Fox BC, Colomo L, Martinez A, Roncador A, Montserrat E, Campo E and Banham AH: High numbers of tumors-infiltrating FoxP3-positive regulatory T cells with improved overall survival in follicular lymphoma. Blood. 108:2957–2964. 2006. View Article : Google Scholar : PubMed/NCBI

18. 

Glas AM, Kersten MJ, Delahaye L, Witteveen AT, Kibbelaar RE, Velds A, Wessels LA, Joosten P, Kerkhoven RM, Bernards R, Van Krieken JH, Kluin PM, van’t Veer LJ and de Jong D: Gene expression profiling in follicular lymphoma to assess clinical aggressiveness and to guide the choice of treatment. Blood. 105:301–307. 2005. View Article : Google Scholar : PubMed/NCBI

19. 

Engelbrekt W, Sander B, Christensson B and Kimby E: CD8+ T-cell content in diagnostic lymph nodes measured by flow cytometry is a predictor of survival in follicular lymphoma. Clin Cancer Res. 13:388–397. 2007.

20. 

Taskinen M, Karjalainen-Lindsberg ML and Leppä S: Prognostic influence of tumor-infiltrating mast cells in patients with follicular lymphoma treated with rituximab and CHOP. Blood. 111:4664–4667. 2008. View Article : Google Scholar : PubMed/NCBI

21. 

Alvaro T, Lejeûne M, Salvado MT, Lopez C, Jaén J and Bosch R: Immunohistochemical patterns of reactive microenvironment are associated with clinicobiologic behavior in follicular lymphoma patients. J Clin Oncol. 24:5350–5357. 2006. View Article : Google Scholar : PubMed/NCBI

22. 

Taskinen M, Karjalainen-Lindsberg ML, Nyman H, Eerola LM and Leppä S: A high tumor-associated macrophage content predicts favorable outcome in follicular lymphoma patients treated with rituximab and cyclophosphamidedoxorubicin-vincristine-prednisone. Clin Cancer Res. 13:5784–5789. 2007. View Article : Google Scholar

23. 

Canioni D, Salles G, Mounier N, Brousse N, Keuppens M, Morchhausser F, Lamy T, Sonnet A, Rousselet MC, Foussard C and Xerri L: High numbers of tumor-associated macrophages have an adverse prognostic value that can be circumvented by rituximab in patients with follicular lymphoma enrolled onto the GELA-GOELAMS FL-2000 trial. J Clin Oncol. 26:440–446. 2008. View Article : Google Scholar

24. 

Swerrdlow SH, Campo E, Lee Harris N, Jaffe E, Pileir A, Stein H, Thiel J and Vardiman J: WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. (4th edition). International Agency for Research on Cancer. 2008.

25. 

Ai W, Hou JZ, Zeiser R, Czerwinski D, Negrin RS and Levy R: Follicular lymphoma B cells induce the conversion of conventional CD4+ cells to T-regulatory cells. Int J Cancer. 124:239–244. 2008. View Article : Google Scholar : PubMed/NCBI

26. 

Alvaro T, Lejeune M, Salvado MT, Bosch R, Garcia JF, Jaén J, Banham AH, Roncador G, Montalban C and Piris M: Outcome in Hodgkin’s lymphoma can be predicted from the presence of accompanying cytotoxic and regulatory T cells. Clin Cancer Res. 11:1467–1473. 2005.

27. 

Chetaille B, Bertucci F, Finetti P, Esterni B, Stamatoullas A, Picquenot JM, Copin MC, Morschhauser F, Casasnovas O, Petrella T, Molina T, Vekhoff A, Feugier P, Bouabdallah R, Birnbaum D, Olive D and Xerri L: Molecular profiling of classical Hodgkin lymphoma tissues uncovers variations in the tumor microenvironment and correlations with EBV infection and outcome. Blood. 113:2765–3775. 2009. View Article : Google Scholar : PubMed/NCBI

28. 

De Jong D, Koster A, Hagenbeek A, Reameakers J, Veldhuizen D, Heisterkamps S, De Boer JP and Vanglabeeke M: Impact of tumor microenvironment on prognosis in follicular lymphoma is dependent on specific treatment protocols. Haematologica. 94:70–77. 2009.PubMed/NCBI

29. 

Glas AM, Kersten MJ, Delahaye LJ, Witteveen AT, Kibbelaar RE, Velds A, Wessels LF, Joosten P, Kerkhoven RM, Bernards R, van Krieken JH, Kluin PM, van ‘t Veer LJ and De Jong D: Gene-expression and immunohistochemical study of specific T-cell subsets and accessory cell types in the transformation and prognosis of follicular lymphoma. J Clin Oncol. 25:390–398. 2007. View Article : Google Scholar : PubMed/NCBI

30. 

De Jong D: Molecular pathogenesis of follicular lymphoma: A cross talk of genetic and immunologic factors. J Clin Oncol. 23:6358–6363. 2005.PubMed/NCBI

31. 

Kelley T, Beck R, Absi A, Jin T, Pohlman B and Hsi E: Biologic predictors in follicular lymphoma: importance of markers of immune response. Leuk Lymphoma. 48:2403–2411. 2007. View Article : Google Scholar : PubMed/NCBI

32. 

Glas AM, Kersten MJ, Delahaye LJ, Witteveen AT, Kibbelaar RE, Velds A, Wessels LF, Joosten P, Kerkhoven RM, Bernards R, van Krieken JH, Kluin PM, van ‘t Veer LJ and de Jong D: Prognostic significance of host immune gene polymorphisms in follicular lymphoma survival. Blood. 109:5439–5446. 2007. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Saifi M, Maran A, Raynaud P, Picot MC, Quittet P, Cartron G, Rossi JF and Costes V: High ratio of interfollicular cd8/foxp3-positive regulatory T cells is associated with a high flipi index and poor overall survival in follicular lymphoma. Exp Ther Med 1: 933-938, 2010.
APA
Saifi, M., Maran, A., Raynaud, P., Picot, M.C., Quittet, P., Cartron, G. ... Costes, V. (2010). High ratio of interfollicular cd8/foxp3-positive regulatory T cells is associated with a high flipi index and poor overall survival in follicular lymphoma. Experimental and Therapeutic Medicine, 1, 933-938. https://doi.org/10.3892/etm.2010.146
MLA
Saifi, M., Maran, A., Raynaud, P., Picot, M. C., Quittet, P., Cartron, G., Rossi, J. F., Costes, V."High ratio of interfollicular cd8/foxp3-positive regulatory T cells is associated with a high flipi index and poor overall survival in follicular lymphoma". Experimental and Therapeutic Medicine 1.6 (2010): 933-938.
Chicago
Saifi, M., Maran, A., Raynaud, P., Picot, M. C., Quittet, P., Cartron, G., Rossi, J. F., Costes, V."High ratio of interfollicular cd8/foxp3-positive regulatory T cells is associated with a high flipi index and poor overall survival in follicular lymphoma". Experimental and Therapeutic Medicine 1, no. 6 (2010): 933-938. https://doi.org/10.3892/etm.2010.146
Copy and paste a formatted citation
x
Spandidos Publications style
Saifi M, Maran A, Raynaud P, Picot MC, Quittet P, Cartron G, Rossi JF and Costes V: High ratio of interfollicular cd8/foxp3-positive regulatory T cells is associated with a high flipi index and poor overall survival in follicular lymphoma. Exp Ther Med 1: 933-938, 2010.
APA
Saifi, M., Maran, A., Raynaud, P., Picot, M.C., Quittet, P., Cartron, G. ... Costes, V. (2010). High ratio of interfollicular cd8/foxp3-positive regulatory T cells is associated with a high flipi index and poor overall survival in follicular lymphoma. Experimental and Therapeutic Medicine, 1, 933-938. https://doi.org/10.3892/etm.2010.146
MLA
Saifi, M., Maran, A., Raynaud, P., Picot, M. C., Quittet, P., Cartron, G., Rossi, J. F., Costes, V."High ratio of interfollicular cd8/foxp3-positive regulatory T cells is associated with a high flipi index and poor overall survival in follicular lymphoma". Experimental and Therapeutic Medicine 1.6 (2010): 933-938.
Chicago
Saifi, M., Maran, A., Raynaud, P., Picot, M. C., Quittet, P., Cartron, G., Rossi, J. F., Costes, V."High ratio of interfollicular cd8/foxp3-positive regulatory T cells is associated with a high flipi index and poor overall survival in follicular lymphoma". Experimental and Therapeutic Medicine 1, no. 6 (2010): 933-938. https://doi.org/10.3892/etm.2010.146
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team