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Article

Evaluation of the combined expression of chemokine SDF-1α and its receptor CXCR4 as a prognostic marker for gastric cancer

  • Authors:
    • Hyo Jin Lee
    • Song Mei Huang
    • Ha Yon Kim
    • Yoon Suk Oh
    • Ji Young Hwang
    • Zhe Long Liang
    • Jeong Ki Min
    • Hwan Jung Yun
    • Ji Young Sul
    • Samyong Kim
    • Deog Yeon Jo
    • Jin Man Kim
  • View Affiliations / Copyright

    Affiliations: Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon, Republic of Korea, Department of Pathology, Chungnam National University School of Medicine, Daejeon, Republic of Korea, Therapeutic Antibody Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea, Department of Surgery, Chungnam National University School of Medicine, Daejeon, Republic of Korea, Department of Pathology and Infection Signaling Network Research Center, Chungnam National University School of Medicine, Daejeon, Republic of Korea
  • Pages: 499-504
    |
    Published online on: March 16, 2011
       https://doi.org/10.3892/etm.2011.228
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Abstract

Chemokine stromal cell-derived factor (SDF)-1α and its receptor CXC chemokine receptor 4 (CXCR4) have been shown to impact cancer progression. Accumulating evidence suggests that CXCR4 and SDF-1α expression is useful for evaluating the risk of gastric cancer progression. Thus, combined analysis of SDF-1α and CXCR4 should have high prognostic potential as a molecular marker for gastric cancer. We investigated the expression of SDF-1α and CXCR4 using immunohistochemistry in relation to prognosis, clinicopathological features and clinical outcomes in 221 cases of primary gastric cancer. Patients were categorized into three groups according to CXCR4 and SDF-1α expression: high CXCR4/high SDF-1α, low CXCR4/low SDF-1α, and high CXCR4/low SDF-1α – low CXCR4/high SDF-1α. No significant differences were noted in age, gender, histology, tumor location, lymphovascular invasion or proportion of tumor size >5 cm among the three groups. However, high CXCR4/high SDF-1α expression in tumor cells was significantly associated with depth of invasion of the tumor, lymph node involvement, and higher tumor stage compared to tumors with low CXCR4/low SDF-1α expression or high CXCR4/low SDF-1α – low CXCR4/high SDF-1α expression. Furthermore, patients with high CXCR4/high SDF-1α expression had the worst patient prognosis, whereas patients who had low CXCR4/low SDF-1α expression showed the most favorable prognosis. In conclusion, CXCR4 and SDF-1α are useful prognostic factors in gastric cancer, and the combination of high CXCR4 protein expression with high SDF-1α expression suggests a dismal prognosis.
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1. 

Kamangar F, Dores GM and Anderson WF: Patterns of cancer incidence, mortality, and prevalence across five continents: defining priorities to reduce cancer disparities in different geographic regions of the world. J Clin Oncol. 24:2137–2150. 2006. View Article : Google Scholar

2. 

Parkin DM, Bray F, Ferlay J and Pisani P: Global cancer statistics. 2002 CA Cancer J Clin. 55:74–108. 2005. View Article : Google Scholar

3. 

Hermans J, Bonenkamp JJ, Boon MC, et al: Adjuvant therapy after curative resection for gastric cancer: meta-analysis of randomized trials. J Clin Oncol. 11:1441–1447. 1993.PubMed/NCBI

4. 

Jackson CB and Giraud AS: STAT3 as a prognostic marker in human gastric cancer. J Gastroenterol Hepatol. 24:505–507. 2009. View Article : Google Scholar : PubMed/NCBI

5. 

Arya M, Patel HR and Williamson M: Chemokines: key players in cancer. Curr Med Res Opin. 19:557–564. 2003. View Article : Google Scholar

6. 

Burger JA and Kipps TJ: CXCR4: a key receptor in the crosstalk between tumor cells and their microenvironment. Blood. 107:1761–1767. 2006. View Article : Google Scholar : PubMed/NCBI

7. 

Scotton CJ, Wilson JL, Scott K, et al: Multiple actions of the chemokine CXCL12 on epithelial tumor cells in human ovarian cancer. Cancer Res. 62:5930–5938. 2002.PubMed/NCBI

8. 

Barbieri F, Bajetto A, Stumm R, et al: Overexpression of stromal cell-derived factor 1 and its receptor CXCR4 induces autocrine/paracrine cell proliferation in human pituitary adenomas. Clin Cancer Res. 14:5022–5032. 2008. View Article : Google Scholar : PubMed/NCBI

9. 

Koshiba T, Hosotani R, Miyamoto Y, et al: Expression of stromal cell-derived factor 1 and CXCR4 ligand receptor system in pancreatic cancer: a possible role for tumor progression. Clin Cancer Res. 6:3530–3535. 2000.PubMed/NCBI

10. 

Muller A, Homey B, Soto H, et al: Involvement of chemokine receptors in breast cancer metastasis. Nature. 410:50–56. 2001. View Article : Google Scholar : PubMed/NCBI

11. 

Ganju RK, Brubaker SA, Meyer J, et al: The alpha-chemokine, stromal cell-derived factor-1, binds to the transmembrane G-protein-coupled CXCR-4 receptor and activates multiple signal transduction pathways. J Biol Chem. 273:23169–23175. 1998. View Article : Google Scholar

12. 

Oh JW, Drabik K, Kutsch O, Choi C, Tousson A and Benveniste EN: CXC chemokine receptor 4 expression and function in human astroglioma cells. J Immunol. 166:2695–2704. 2001. View Article : Google Scholar : PubMed/NCBI

13. 

Orimo A, Gupta PB, Sgroi DC, et al: Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell. 121:335–348. 2005. View Article : Google Scholar

14. 

Mirisola V, Zuccarino A, Bachmeier BE, et al: CXCL12/SDF1 expression by breast cancers is an independent prognostic marker of disease-free and overall survival. Eur J Cancer. 45:2579–2587. 2009. View Article : Google Scholar : PubMed/NCBI

15. 

Yoshitake N, Fukui H, Yamagishi H, et al: Expression of SDF-1 alpha and nuclear CXCR4 predicts lymph node metastasis in colorectal cancer. Br J Cancer. 98:1682–1689. 2008. View Article : Google Scholar : PubMed/NCBI

16. 

Schimanski CC, Schwald S, Simiantonaki N, et al: Effect of chemokine receptors CXCR4 and CCR7 on the metastatic behavior of human colorectal cancer. Clin Cancer Res. 11:1743–1750. 2005. View Article : Google Scholar : PubMed/NCBI

17. 

Arigami T, Natsugoe S, Uenosono Y, et al: CCR7 and CXCR4 expression predicts lymph node status including micrometastasis in gastric cancer. Int J Oncol. 35:19–24. 2009. View Article : Google Scholar : PubMed/NCBI

18. 

Yasumoto K, Koizumi K, Kawashima A, et al: Role of the CXCL12/CXCR4 axis in peritoneal carcinomatosis of gastric cancer. Cancer Res. 66:2181–2187. 2006. View Article : Google Scholar : PubMed/NCBI

19. 

Hashimoto I, Koizumi K, Tatematsu M, et al: Blocking on the CXCR4/mTOR signalling pathway induces the anti-metastatic properties and autophagic cell death in peritoneal disseminated gastric cancer cells. Eur J Cancer. 44:1022–1029. 2008. View Article : Google Scholar : PubMed/NCBI

20. 

Zieker D, Königsrainer I, Traub F, et al: PGK1 a potential marker for peritoneal dissemination in gastric cancer. Cell Physiol Biochem. 21:429–436. 2008. View Article : Google Scholar : PubMed/NCBI

21. 

Lee HJ, Kim SW, Kim HY, et al: Chemokine receptor CXCR4 expression, function, and clinical implications in gastric cancer. Int J Oncol. 34:473–480. 2009.PubMed/NCBI

22. 

Ishigami S, Natsugoe S, Okumura H, et al: Clinical implication of CXCL12 expression in gastric cancer. Ann Surg Oncol. 14:3154–3158. 2007. View Article : Google Scholar : PubMed/NCBI

23. 

Japanese Gastric Cancer Association: Japanese Classification of Gastric Carcinoma. (2nd English edition). Gastric Cancer. 1:10–24. 1998. View Article : Google Scholar

24. 

Kim SW, Kim HY, Lee HJ, Yun HJ, Kim S and Jo DY: Stromal cell-derived factor-1 promotes myeloma cell growth in both aurocrine and paracrine manners. Korean J Hematol. 43:127–137. 2008. View Article : Google Scholar

25. 

Guleng B, Tateishi K, Ohta M, et al: Blockade of the stromal cell-derived factor-1/CXCR4 axis attenuates in vivo tumor growth by inhibiting angiogenesis in a vascular endothelial growth factor-independent manner. Cancer Res. 65:5864–5871. 2005. View Article : Google Scholar

26. 

Schimanski CC, Galle PR and Moehler M: Chemokine receptor CXCR4 – prognostic factor for gastrointestinal tumors. World J Gastroenterol. 14:4721–4724. 2008.

27. 

Iwasa S, Yanagawa T, Fan J and Katoh R: Expression of CXCR4 and its ligand SDF-1 in intestinal-type gastric cancer is associated with lymph node and liver metastasis. Anticancer Res. 29:4751–4758. 2009.PubMed/NCBI

28. 

Tsuboi K, Kodera Y, Nakanishi H, et al: Expression of CXCL12 and CXCR4 in pT3-stage gastric cancer does not correlate with peritoneal metastasis. Oncol Rep. 20:1117–1123. 2008.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Lee HJ, Huang SM, Kim HY, Oh YS, Hwang JY, Liang ZL, Min JK, Yun HJ, Sul JY, Kim S, Kim S, et al: Evaluation of the combined expression of chemokine SDF-1α and its receptor CXCR4 as a prognostic marker for gastric cancer. Exp Ther Med 2: 499-504, 2011.
APA
Lee, H.J., Huang, S.M., Kim, H.Y., Oh, Y.S., Hwang, J.Y., Liang, Z.L. ... Kim, J.M. (2011). Evaluation of the combined expression of chemokine SDF-1α and its receptor CXCR4 as a prognostic marker for gastric cancer. Experimental and Therapeutic Medicine, 2, 499-504. https://doi.org/10.3892/etm.2011.228
MLA
Lee, H. J., Huang, S. M., Kim, H. Y., Oh, Y. S., Hwang, J. Y., Liang, Z. L., Min, J. K., Yun, H. J., Sul, J. Y., Kim, S., Jo, D. Y., Kim, J. M."Evaluation of the combined expression of chemokine SDF-1α and its receptor CXCR4 as a prognostic marker for gastric cancer". Experimental and Therapeutic Medicine 2.3 (2011): 499-504.
Chicago
Lee, H. J., Huang, S. M., Kim, H. Y., Oh, Y. S., Hwang, J. Y., Liang, Z. L., Min, J. K., Yun, H. J., Sul, J. Y., Kim, S., Jo, D. Y., Kim, J. M."Evaluation of the combined expression of chemokine SDF-1α and its receptor CXCR4 as a prognostic marker for gastric cancer". Experimental and Therapeutic Medicine 2, no. 3 (2011): 499-504. https://doi.org/10.3892/etm.2011.228
Copy and paste a formatted citation
x
Spandidos Publications style
Lee HJ, Huang SM, Kim HY, Oh YS, Hwang JY, Liang ZL, Min JK, Yun HJ, Sul JY, Kim S, Kim S, et al: Evaluation of the combined expression of chemokine SDF-1α and its receptor CXCR4 as a prognostic marker for gastric cancer. Exp Ther Med 2: 499-504, 2011.
APA
Lee, H.J., Huang, S.M., Kim, H.Y., Oh, Y.S., Hwang, J.Y., Liang, Z.L. ... Kim, J.M. (2011). Evaluation of the combined expression of chemokine SDF-1α and its receptor CXCR4 as a prognostic marker for gastric cancer. Experimental and Therapeutic Medicine, 2, 499-504. https://doi.org/10.3892/etm.2011.228
MLA
Lee, H. J., Huang, S. M., Kim, H. Y., Oh, Y. S., Hwang, J. Y., Liang, Z. L., Min, J. K., Yun, H. J., Sul, J. Y., Kim, S., Jo, D. Y., Kim, J. M."Evaluation of the combined expression of chemokine SDF-1α and its receptor CXCR4 as a prognostic marker for gastric cancer". Experimental and Therapeutic Medicine 2.3 (2011): 499-504.
Chicago
Lee, H. J., Huang, S. M., Kim, H. Y., Oh, Y. S., Hwang, J. Y., Liang, Z. L., Min, J. K., Yun, H. J., Sul, J. Y., Kim, S., Jo, D. Y., Kim, J. M."Evaluation of the combined expression of chemokine SDF-1α and its receptor CXCR4 as a prognostic marker for gastric cancer". Experimental and Therapeutic Medicine 2, no. 3 (2011): 499-504. https://doi.org/10.3892/etm.2011.228
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