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Article

Sorafenib and hepatic arterial infusion chemotherapy for unresectable advanced hepatocellular carcinoma: A comparative study

  • Authors:
    • Yasunari Hiramine
    • Hirofumi Uto
    • Yasushi Imamura
    • Kazuaki Tabu
    • Yoshirou Baba
    • Takuya Hiwaki
    • Yukihiko Sho
    • Kenji Tahara
    • Hirofumi Higashi
    • Tutomu Tamai
    • Makoto Oketani
    • Akio Ido
    • Hirohito Tsubouchi
  • View Affiliations / Copyright

    Affiliations: Department of Internal Medicine, Kagoshima Kouseiren Hospital, Kagoshima 890-0061, Japan, Department of Digestive and Lifestyle-Related Disease, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8520, Japan, Department of Hygiene and Public Health, School of Medicine, National Institute of Fitness and Sports in Kanoya, Kanoya, Kagoshima 891-2393, Japan, Department of Digestive and Lifestyle-Related Disease, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8520, Japan
  • Pages: 433-441
    |
    Published online on: March 21, 2011
       https://doi.org/10.3892/etm.2011.237
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Abstract

Sorafenib is a kinase-targeted drug that has high efficacy for advanced hepatocellular carcinoma (HCC). The aim of the present study was to determine whether sorafenib is more effective than hepatic arterial infusion chemotherapy (HAIC) for HCC. Twenty patients treated with sorafenib (sorafenib group) initiated at 800 mg/day and 45 patients treated with HAIC (HAIC group) for unresectable Child-Pugh A advanced HCC were investigated retrospectively. The treatment effect was assessed using the Response Evaluation Criteria in Solid Tumors (RECIST). As a result, the overall response rate was significantly lower in the sorafenib group than in the HAIC group (P=0.03), while the disease control and survival rates did not differ between the two groups. In the sorafenib group, treatment was discontinued in 19 patients, including 12 due to side effects. In subgroups of patients treated with sorafenib, the survival rate was significantly lower in patients (n=11) administered sorafenib for <60 days compared to those (n=9) treated for ≥60 days. A shorter treatment period (<60 days) was an independent risk factor for unfavorable survival [hazard ratio (HR), 3.34; 95% confidence interval (CI), 1.45-7.66 vs. HAIC], while survival in patients treated with sorafenib for ≥60 days did not differ from those treated with HAIC (HR, 0.79; 95% CI, 0.27-2.34). In conclusion, the disease control and survival rates of patients treated with sorafenib for advanced HCC were comparable to such rates in patients treated with HAIC. However, the prognosis was poor when long-term sorafenib treatment was not possible due to side effects, demonstrating the importance of patient selection for sorafenib treatment.
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1. 

Cabibbo G, Latteri F, Antonucci M and Craxì A: Multimodal approaches to the treatment of hepatocellular carcinoma. Nat Clin Pract Gastroenterol Hepatol. 6:159–169. 2009. View Article : Google Scholar : PubMed/NCBI

2. 

Kim BK, Park JY, Choi HJ, Kim DY, Ahn SH, Kim JK, Lee DY, Lee KH and Han KH: Long-term clinical outcomes of hepatic arterial infusion chemotherapy with cisplatin with or without 5-fluorouracil in locally advanced hepatocellular carcinoma. J Cancer Res Clin Oncol. June 16–2010.(Epub ahead of print).

3. 

Ikeda M, Maeda S, Ashihara H, Nagahama H, Tanaka M and Sasaki Y: Transcatheter arterial infusion chemotherapy with cisplatin-lipiodol suspension in patients with hepatocellular carcinoma. J Gastroenterol. 45:60–67. 2010. View Article : Google Scholar

4. 

Llovet JM, Ricci S, Mazzaferro V, Hilgard P, Gane E, Blanc JF, de Oliveira AC, Santoro A, Raoul JL, Forner A, Schwartz M, Porta C, Zeuzem S, Bolondi L, Greten TF, Galle PR, Seitz JF, Borbath I, Häussinger D, Giannaris T, Shan M, Moscovici M, Voliotis D and Bruix J: SHARP investigators study group: sorafenib in advanced hepatocellular carcinoma. N Engl J Med. 359:378–390. 2008. View Article : Google Scholar : PubMed/NCBI

5. 

Cheng AL, Kang YK, Chen Z, Tsao CJ, Qin S, Kim JS, Luo R, Feng J, Ye S, Yang TS, Xu J, Sun Y, Liang H, Liu J, Wang J, Tak WY, Pan H, Burock K, Zou J, Voliotis D and Guan Z: Efficacy and safety of sorafenib in patients in Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomized, double-blind, placebo-controlled trial. Lancet Oncol. 10:25–34. 2009. View Article : Google Scholar

6. 

Llovet JM, Di Bisceglie AM, Bruix J, Kramer BS, Lencioni R, Zhu AX, Sherman M, Schwartz M, Lotze M, Talwalkar J and Gores GJ: Panel of experts in HCC-design clinical trials: design and endpoints of clinical trials in hepatocellular carcinoma. J Natl Cancer Inst. 100:698–711. 2008. View Article : Google Scholar

7. 

Kudo M: The 2008 Okuda lecture: management of hepatocellular carcinoma: from surveillance to molecular-targeted therapy. J Gastroenterol Hepatol. 25:439–452. 2010. View Article : Google Scholar : PubMed/NCBI

8. 

Cabrera R and Nelson DR: The management of hepatocellular carcinoma. Aliment Pharmacol Ther. 31:461–476. 2010. View Article : Google Scholar : PubMed/NCBI

9. 

Urabe T, Kaneko S, Matsushita E, Unoura M and Kobayashi K: Clinical pilot study of intrahepatic arterial chemotherapy with methotrexate, 5-fluorouracil, cisplatin and subcutaneous interferon-alpha-2b for patients with locally advanced hepatocellular carcinoma. Oncology. 55:39–47. 1998. View Article : Google Scholar

10. 

Kuroda M, Kobayashi Y, Urawa N, Yamamoto M, Mifuji R, Araki J, Tanaka H, Horiike S, Itani T, Furjita N, Konishi M, Iwasa M, Kaito M and Adachi Y: Hepatic arterial infusion of 5-fluorouracil in combination with subcutaneous interferon-alpha for advanced hepatocellular carcinoma. Hepatogastroenterology. 54:518–521. 2007.

11. 

Uka K, Aikata H, Takaki S, Miki D, Kawaoka T, Jeong SC, Takahashi S, Toyota N, Ito K and Chayama K: Pretreatment predictor of response, time to progression, and survival to intraarterial 5-fluorouracil/interferon combination therapy in patients with advanced hepatocellular carcinoma. J Gastroenterol. 42:845–853. 2007. View Article : Google Scholar

12. 

Ando E, Tanaka M, Yamashita F, Kuromatsu R, Yutani S, Fukumori K, Sumie S, Yano Y, Okuda K and Sata M: Hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma with portal vein tumor thrombosis: analysis of 48 cases. Cancer. 95:588–595. 2002. View Article : Google Scholar

13. 

Tanioka H, Tsuji A, Morita S, Horimi T, Takamatsu M, Shirasaka T, Mizushima T, Ochi K, Kiura K and Tanimoto M: Combination chemotherapy with continuous 5-fluorouracil and low-dose cisplatin infusion for advanced hepatocellular carcinoma. Anticancer Res. 23:1891–1897. 2003.PubMed/NCBI

14. 

Yoshikawa M, Ono N, Yodono H, Ichida T and Nakamura H: Phase II study of hepatic arterial infusion of a fine-powder formulation of cisplatin for advanced hepatocellular carcinoma. Hepatol Res. 38:474–483. 2008. View Article : Google Scholar

15. 

Kondo M, Nagano H, Sakon M, Yamamoto H, Morimoto O, Arai I, Miyamoto A, Eguchi H, Dono K, Nakamori S, Umeshita K, Wakasa K, Ohmoto Y and Monden M: Expression of interferon alpha/beta receptor in human hepatocellular carcinoma. Int J Oncol. 17:83–88. 2000.PubMed/NCBI

16. 

Ota H, Nagano H, Sakon M, Eguchi H, Kondo M, Yamamoto T, Nakamura M, Damdinsuren B, Wada H, Marubashi S, Miyamoto A, Dono K, Umeshita K, Nakamori S, Wakasa K and Monden M: Treatment of hepatocellular carcinoma with major portal vein thrombosis by combined therapy with subcutaneous interferon-alpha and intra-arterial 5-fluorouracil; role of type 1 interferon receptor expression. Br J Cancer. 93:557–564. 2005. View Article : Google Scholar

17. 

Kudo M: Current status of molecularly targeted therapy for hepatocellular carcinoma: clinical practice. Int J Clin Oncol. 15:242–255. 2010. View Article : Google Scholar : PubMed/NCBI

18. 

Shen YC, Hsu C and Cheng AL: Molecular targeted therapy for advanced hepatocellular carcinoma: current status and future perspectives. J Gastroenterol. 45:794–807. 2010. View Article : Google Scholar : PubMed/NCBI

19. 

Park JY, Ahn SH, Yoon YJ, Kim JK, Lee HW, Lee do Y, Chon CY, Moon YM and Han KH: Repetitive short-course hepatic arterial infusion chemotherapy with high-dose 5-fluorouracil and cisplatin in patients with advanced hepatocellular carcinoma. Cancer. 110:129–137. 2007. View Article : Google Scholar

20. 

Furuse J, Ishii H, Nakachi K, Suzuki E, Shimizu S and Nakajima K: Phase I study of sorafenib in Japanese patients with hepatocellular carcinoma. Cancer Sci. 99:159–165. 2008.PubMed/NCBI

21. 

Ando E, Yamashita F, Tanaka M and Tanikawa K: A novel chemotherapy for advanced hepatocellular carcinoma with tumor thrombosis of the main trunk of the portal vein. Cancer. 79:1890–1896. 1997. View Article : Google Scholar : PubMed/NCBI

22. 

Therasse P, Arbuck SG, Eisenhauer EA, Wanders J, Kaplan RS, Rubinstein L, Verweij J, van Glabbeke M, van Oosterom AT, Christian MC and Gwyther SG: New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Rreatment of Cancer, national Cancer Institute of the United States, national Cancer Institute of Canada. J Natl Cancer Inst. 92:205–216. 2000. View Article : Google Scholar

23. 

Japanese translation of common terminology criteria for adverse events (CTCAE), and instructions and guidelines. Int J Clin Oncol. 9(Suppl. 3): S1–S82. 2004.(In Japanese).

24. 

Rouillier P, Senesse P, Cottet V, Valléau A, Faivre J and Boutron-Ruault MC: Dietary patterns and the adenomacarcinoma sequence of colorectal cancer. Eur J Nutr. 44:311–318. 2005. View Article : Google Scholar : PubMed/NCBI

25. 

Furuse J: Sorafenib for the treatment of unresectable hepatocellular-carcinoma. Biologics. 2:779–788. 2008.PubMed/NCBI

26. 

Abou-Alfa GK, Schwartz L, Ricci S, Amadori D, Santoro A, Figer A, de Greve J, Douillard JY, Lathia C, Schwartz B, Taylor I, Moscovici M and Saltz LB: Phase II study of sorafenib in patients with advanced hepatocellular carcinoma. J Clin Oncol. 24:4293–4300. 2006. View Article : Google Scholar

27. 

Yang CH, Lin WC, Chuang CK, Chang YC, Pang ST, Lin YC, Kuo TT, Hsieh JJ and Chang JW: Hand-foot skin reaction in patients treated with sorafenib: a clinicopathological study of cutaneous manifestations due to multitargeted kinase inhibitor therapy. Br J Dermatol. 158:592–596. 2008. View Article : Google Scholar

28. 

Hakamada K, Kimura N, Miura T, Morohashi H, Ishido K, Nara M, Toyoki Y, Narumi S and Sasaki M: Des-gamma-carboxy prothrombin as an important prognostic indicator in patients with small hepatocellular carcinoma. World J Gastroenterol. 14:1370–1377. 2008. View Article : Google Scholar

29. 

Bruix J and Llovet JM: Prognostic prediction and treatment strategy in hepatocellular carcinoma. Hepatology. 35:519–524. 2002. View Article : Google Scholar : PubMed/NCBI

30. 

Woo HY, Bae SH, Park JY, Han KH, Chun HJ, Choi BG, Im HU, Choi JY, Yoon SK, Cheong JY, Cho SW, Jang BK, Hwang JS, Kim SG, Kim YS, Seo YS, Yim HJ and Um SH: A randomized comparative study of high-dose and low-dose hepatic arterial infusion chemotherapy for intractable, advanced hepatocellular carcinoma. Cancer Chemother Pharmacol. 65:373–382. 2010. View Article : Google Scholar

31. 

Kudo M and Ueshima K: Positioning of a molecular-targeted agent, sorafenib, in the treatment algorithm for hepatocellular carcinoma and implication of many complete remission cases in Japan. Oncology. 78(Suppl. 1): S154–S166. 2010. View Article : Google Scholar

32. 

Abou-Alfa GK, Johnson P, Knox JJ, Capanu M, Davidenko I, Lacava J, Leung T, Gansukh B and Saltz LB: Doxorubicin plus sorafenib vs. doxorubicin alone in patients with advanced hepatocellular carcinoma: a randomized trial. JAMA. 304:2154–2160. 2010. View Article : Google Scholar : PubMed/NCBI

33. 

Vincenzi B, Santini D, Russo A, Addeo R, Giuliani F, Montella L, Rizzo S, Venditti O, Frezza AM, Caraglia M, Colucci G, del Prete S and Tonini G: Early skin toxicity as a predictive factor for tumor control in hepatocellular carcinoma patients treated with sorafenib. Oncologis. 15:85–92. 2010. View Article : Google Scholar

34. 

La Vine DB, Coleman TA, Davis CH, Carbonell CE and Davis WB: Frequent dose interruptions are required for patients receiving oral kinase inhibitor therapy for advanced renal cell carcinoma. Am J Clin Oncol. 33:217–220. 2010.PubMed/NCBI

35. 

Tanaka Y, Nishida N, Sugiyama M, Tokunaga K and Mizokami M: Lambda-interferons and the single nucleotide polymorphisms: a milestone to tailor-made therapy for chronic hepatitis C. Hepatol Res. 40:449–460. 2010. View Article : Google Scholar

36. 

Okanoue T, Itoh Y, Hashimoto H, Yasui K, Minami M, Takehara T, Tanaka E, Onji M, Toyota J, Chayama K, Yoshioka K, Izumi N, Akuta N and Kumada H: Predictive values of amino acid sequences of the core and nS5A regions in antiviral therapy for hepatitis C: a Japanese multi-center study. J Gastroenterol. 44:952–963. 2009. View Article : Google Scholar

37. 

Villanueva A, Minguez B, Forner A, Reig M and Llovet JM: Hepatocellular carcinoma: novel molecular approaches for diagnosis, prognosis, and therapy. Annu Rev Med. 61:317–328. 2010. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Hiramine Y, Uto H, Imamura Y, Tabu K, Baba Y, Hiwaki T, Sho Y, Tahara K, Higashi H, Tamai T, Tamai T, et al: Sorafenib and hepatic arterial infusion chemotherapy for unresectable advanced hepatocellular carcinoma: A comparative study. Exp Ther Med 2: 433-441, 2011.
APA
Hiramine, Y., Uto, H., Imamura, Y., Tabu, K., Baba, Y., Hiwaki, T. ... Tsubouchi, H. (2011). Sorafenib and hepatic arterial infusion chemotherapy for unresectable advanced hepatocellular carcinoma: A comparative study. Experimental and Therapeutic Medicine, 2, 433-441. https://doi.org/10.3892/etm.2011.237
MLA
Hiramine, Y., Uto, H., Imamura, Y., Tabu, K., Baba, Y., Hiwaki, T., Sho, Y., Tahara, K., Higashi, H., Tamai, T., Oketani, M., Ido, A., Tsubouchi, H."Sorafenib and hepatic arterial infusion chemotherapy for unresectable advanced hepatocellular carcinoma: A comparative study". Experimental and Therapeutic Medicine 2.3 (2011): 433-441.
Chicago
Hiramine, Y., Uto, H., Imamura, Y., Tabu, K., Baba, Y., Hiwaki, T., Sho, Y., Tahara, K., Higashi, H., Tamai, T., Oketani, M., Ido, A., Tsubouchi, H."Sorafenib and hepatic arterial infusion chemotherapy for unresectable advanced hepatocellular carcinoma: A comparative study". Experimental and Therapeutic Medicine 2, no. 3 (2011): 433-441. https://doi.org/10.3892/etm.2011.237
Copy and paste a formatted citation
x
Spandidos Publications style
Hiramine Y, Uto H, Imamura Y, Tabu K, Baba Y, Hiwaki T, Sho Y, Tahara K, Higashi H, Tamai T, Tamai T, et al: Sorafenib and hepatic arterial infusion chemotherapy for unresectable advanced hepatocellular carcinoma: A comparative study. Exp Ther Med 2: 433-441, 2011.
APA
Hiramine, Y., Uto, H., Imamura, Y., Tabu, K., Baba, Y., Hiwaki, T. ... Tsubouchi, H. (2011). Sorafenib and hepatic arterial infusion chemotherapy for unresectable advanced hepatocellular carcinoma: A comparative study. Experimental and Therapeutic Medicine, 2, 433-441. https://doi.org/10.3892/etm.2011.237
MLA
Hiramine, Y., Uto, H., Imamura, Y., Tabu, K., Baba, Y., Hiwaki, T., Sho, Y., Tahara, K., Higashi, H., Tamai, T., Oketani, M., Ido, A., Tsubouchi, H."Sorafenib and hepatic arterial infusion chemotherapy for unresectable advanced hepatocellular carcinoma: A comparative study". Experimental and Therapeutic Medicine 2.3 (2011): 433-441.
Chicago
Hiramine, Y., Uto, H., Imamura, Y., Tabu, K., Baba, Y., Hiwaki, T., Sho, Y., Tahara, K., Higashi, H., Tamai, T., Oketani, M., Ido, A., Tsubouchi, H."Sorafenib and hepatic arterial infusion chemotherapy for unresectable advanced hepatocellular carcinoma: A comparative study". Experimental and Therapeutic Medicine 2, no. 3 (2011): 433-441. https://doi.org/10.3892/etm.2011.237
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