Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
May-June 2011 Volume 2 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-June 2011 Volume 2 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Retinoid acid receptors in human colorectal cancer: An unexpected link with patient outcome

  • Authors:
    • Aurélie Perraud
    • Michelle Nouaille
    • Hussein Akil
    • Daniel Petit
    • François Labrousse
    • Marie-Odile Jauberteau
    • Muriel Mathonnet
  • View Affiliations / Copyright

    Affiliations: Université de Limoges, EA 3842, Homéostasie Cellulaire et Pathologies, Faculté de Médecine et de Pharmacie, 87025 Limoges Cedex, France, Service de Chirurgie Digestive Endocrinienne et Générale, CHU de Limoges, 87042 Limoges Cedex 1, France, UMR 1061 INRA/Université de Limoges, 87060 Limoges Cedex, France, Laboratoire d'Anatomopathologie, CHU de Limoges, 87042 Limoges Cedex 1, France
  • Pages: 491-497
    |
    Published online on: March 21, 2011
       https://doi.org/10.3892/etm.2011.242
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The status of the three retinoic acid receptors (RARs) α, β and γ in human colorectal cancer (CRC) has not as yet been examined. RARs are in part responsible for the actions of the retinoids (vitamin A and its derivatives), which are essential for human health and survival due to their extensive involvement in numerous cellular processes, in particular in epithelial morphology. The present study examined the expression of the three RARs in CRC using immunohisto­chemical analysis of paraffin-embedded tissue sections. RAR expression in tumor (T) and adjacent non-tumor (NT) specimens from stage I (n=6), stage II (n=34), stage III (n=26) and stage IV (n=14) CRC patients was compared with that in normal mucous membranes (n=10) from control individuals. The findings were correlated with tumor grade, treatment response (progression during treatment, remission, chemoresistance) and survival as clinicopathological parameters. RARα and γ expression was decreased with CRC stage in the T tissues (P=0.016 and P=0.052, respectively), suggesting that they may be used as predictive markers. RARβ expression in the NT tissues was associated with a more favorable prognosis (P=0.04). These results provide important information on the tumor microenvironment (the area adjacent to tumor cells).
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

View References

1. 

Wolbach B and Howe PR: Tissue changes following deprivation of fat soluble A vitamin. J Exp Med. 42:753–777. 1925. View Article : Google Scholar

2. 

De Luca LM: Retinoids and their receptors in differentiation, embryogenesis, and neoplasia. FASEB J. 5:2924–2933. 1991.PubMed/NCBI

3. 

Altucci L and Gronemeyer H: The promise of retinoids to fight against cancer. Nat Rev Cancer. 1:181–193. 2001. View Article : Google Scholar : PubMed/NCBI

4. 

Mongan NP and Gudas LJ: Diverse actions of retinoid receptors in cancer prevention and treatment. Differentiation. 75:853–870. 2007. View Article : Google Scholar : PubMed/NCBI

5. 

Asou N: All-trans retinoic acid in the treatment of acute promyelocytic leukemia. Intern Med. 46:91–93. 2007. View Article : Google Scholar : PubMed/NCBI

6. 

Degos L and Wang ZY: All trans retinoic acid in acute promyelocytic leukemia. Oncogene. 20:7140–7145. 2001. View Article : Google Scholar : PubMed/NCBI

7. 

Nagy L, Thomazy VA, Shipley GL, et al: Activation of retinoid X receptors induces apoptosis in HL-60 cell lines. Mol Cell Biol. 15:3540–3551. 1995.PubMed/NCBI

8. 

Germain P, Staels B, Dacquet C, Spedding M and Laudet V: Overview of nomenclature of nuclear receptors. Pharmacol Rev. 58:685–704. 2006. View Article : Google Scholar : PubMed/NCBI

9. 

Germain P, Chambon P, Eichele G, et al: International Union of Pharmacology. LX Retinoic acid receptors. Pharmacol Rev. 58:712–725. 2006. View Article : Google Scholar : PubMed/NCBI

10. 

Germain P, Chambon P, Eichele G, et al: International Union of Pharmacology. LXIII Retinoid X receptors. Pharmacol Rev. 58:760–772. 2006. View Article : Google Scholar : PubMed/NCBI

11. 

Sun SY: Retinoic acid receptor beta and colon cancer. Cancer Biol Ther. 3:87–88. 2004. View Article : Google Scholar : PubMed/NCBI

12. 

Li R, Saito T, Tanaka R, et al: Hypermethylation in promoter region of retinoic acid receptor-beta gene and immunohistochemical findings on retinoic acid receptors in carcinogenesis of endometrium. Cancer Lett. 219:33–40. 2005. View Article : Google Scholar : PubMed/NCBI

13. 

Xu XC, Ro JY, Lee JS, Shin DM, Hong WK and Lotan R: Differential expression of nuclear retinoid receptors in normal, premalignant, and malignant head and neck tissues. Cancer Res. 54:3580–3587. 1994.PubMed/NCBI

14. 

Kamradt J and Reichrath J: Expression of retinoic acid receptor proteins in basal cell carcinomas: an immunohistochemical analysis. J Histochem Cytochem. 44:1415–1420. 1996. View Article : Google Scholar : PubMed/NCBI

15. 

Widschwendter M, Berger J, Daxenbichler G, et al: Loss of retinoic acid receptor beta expression in breast cancer and morphologically normal adjacent tissue but not in the normal breast tissue distant from the cancer. Cancer Res. 57:4158–4161. 1997.PubMed/NCBI

16. 

Picard E, Seguin C, Monhoven N, et al: Expression of retinoid receptor genes and proteins in non-small-cell lung cancer. J Natl Cancer Inst. 91:1059–1066. 1999. View Article : Google Scholar : PubMed/NCBI

17. 

Zhang W, Rashid A, Wu H and Xu XC: Differential expression of retinoic acid receptors and p53 protein in normal, premalignant, and malignant esophageal tissues. J Cancer Res Clin Oncol. 127:237–242. 2001. View Article : Google Scholar : PubMed/NCBI

18. 

Richter F, Joyce A, Fromowitz F, et al: Immunohistochemical localization of the retinoic acid receptors in human prostate. J Androl. 23:830–838. 2002.PubMed/NCBI

19. 

Haugen BR, Larson LL, Pugazhenthi U, et al: Retinoic acid and retinoid X receptors are differentially expressed in thyroid cancer and thyroid carcinoma cell lines and predict response to treatment with retinoids. J Clin Endocrinol Metab. 89:272–280. 2004. View Article : Google Scholar

20. 

Karamouzis MV, Sotiropoulou-Bonikou G, Vandoros G, Varakis I and Papavassiliou AG: Differential expression of retinoic acid receptor beta (RARβ) and the AP-1 transcription factor in normal, premalignant and malignant human laryngeal tissues. Eur J Cancer. 40:761–773. 2004.

21. 

Ralhan R, Chakravarti N, Kaur J, et al: Clinical significance of altered expression of retinoid receptors in oral precancerous and cancerous lesions: Relationship with cell cycle regulators. Int J Cancer. 118:1077–1089. 2006. View Article : Google Scholar : PubMed/NCBI

22. 

Alvarez S, Germain P, Alvarez R, Rodriguez-Barrios F, Gronemeyer H and de Lera AR: Structure, function and modulation of retinoic acid receptor beta, a tumor suppressor. Int J Biochem Cell Biol. 39:1406–1415. 2007. View Article : Google Scholar : PubMed/NCBI

23. 

Bossard N, Veltenc M, Remonteta L, et al: Survival of cancer patients in France: A population-based study from The Association of the French Cancer Registries (FRANCIM). Eur J Cancer. 43:149–160. 2007. View Article : Google Scholar : PubMed/NCBI

24. 

Greene FL, Page DL, Fleming I, et al: AJCC (American Joint Committee on Cancer) Cancer Staging Manual. 6th edition. Springer-Verlag; New York: pp. 1132002

25. 

Gerdes J, Lemke H, Baisch H, Wacker HH, Schwab U and Stein H: Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67. J Immunol. 133:1710–1715. 1984.PubMed/NCBI

26. 

Du L, Wang H, He L, et al: CD44 is of functional importance for colorectal cancer stem cells. Clin Cancer Res. 14:6751–6760. 2008. View Article : Google Scholar : PubMed/NCBI

27. 

Hammer Ø, Harper DAT and Ryan PD: PAST: Paleontological statistics software package for education and data analysis. Palaeontologia Electronica. 4:92001.

28. 

Gyftopoulos K, Perimenis P, Sotiropoulou-Bonikou G, Sakellaropoulos G, Varakis I and Barbalias GA: Immunohistochemical detection of retinoic acid receptor-alpha in prostate carcinoma: correlation with proliferative activity and tumor grade. Int Urol Nephrol. 32:263–269. 2000. View Article : Google Scholar

29. 

Xu XC: Tumor-suppressive activity of retinoic acid receptor-beta in cancer. Cancer Lett. 253:14–24. 2007. View Article : Google Scholar : PubMed/NCBI

30. 

Van der Leede BM, Geertzema J, Vroom TM, et al: Immunohistochemical analysis of retinoic acid receptor-alpha in human breast tumors: retinoic acid receptor-alpha expression correlates with proliferative activity. Am J Pathol. 148:1905–1914. 1996.PubMed/NCBI

31. 

Lee MO, Han SY, Jiang S, Park JH and Kim SJ: Differential effects of retinoic acid on growth and apoptosis in human colon cancer cell lines associated with the induction of retinoic acid receptor beta. Biochem Pharmacol. 59:485–496. 2000. View Article : Google Scholar : PubMed/NCBI

32. 

Nicke B, Kaiser A, Wiedenmann B, Riecken EO and Rosewicz S: Retinoic acid receptor alpha mediates growth inhibition by retinoids in human colon carcinoma HT29 cells. Biochem Biophys Res Commun. 261:572–577. 1999. View Article : Google Scholar : PubMed/NCBI

33. 

Kim EJ, Kang YH, Schaffer BS, Bach LA, MacDonald RG and Park JH: Inhibition of Caco-2 cell proliferation by all-trans retinoic acid: role of insulin-like growth factor binding protein-6. J Cell Physiol. 190:92–100. 2002. View Article : Google Scholar : PubMed/NCBI

34. 

Freemantle SJ, Spinella MJ and Dmitrovsky E: Retinoids in cancer therapy and chemoprevention: promise meets resistance. Oncogene. 22:7305–7315. 2003. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Perraud A, Nouaille M, Akil H, Petit D, Labrousse F, Jauberteau M and Mathonnet M: Retinoid acid receptors in human colorectal cancer: An unexpected link with patient outcome. Exp Ther Med 2: 491-497, 2011.
APA
Perraud, A., Nouaille, M., Akil, H., Petit, D., Labrousse, F., Jauberteau, M., & Mathonnet, M. (2011). Retinoid acid receptors in human colorectal cancer: An unexpected link with patient outcome. Experimental and Therapeutic Medicine, 2, 491-497. https://doi.org/10.3892/etm.2011.242
MLA
Perraud, A., Nouaille, M., Akil, H., Petit, D., Labrousse, F., Jauberteau, M., Mathonnet, M."Retinoid acid receptors in human colorectal cancer: An unexpected link with patient outcome". Experimental and Therapeutic Medicine 2.3 (2011): 491-497.
Chicago
Perraud, A., Nouaille, M., Akil, H., Petit, D., Labrousse, F., Jauberteau, M., Mathonnet, M."Retinoid acid receptors in human colorectal cancer: An unexpected link with patient outcome". Experimental and Therapeutic Medicine 2, no. 3 (2011): 491-497. https://doi.org/10.3892/etm.2011.242
Copy and paste a formatted citation
x
Spandidos Publications style
Perraud A, Nouaille M, Akil H, Petit D, Labrousse F, Jauberteau M and Mathonnet M: Retinoid acid receptors in human colorectal cancer: An unexpected link with patient outcome. Exp Ther Med 2: 491-497, 2011.
APA
Perraud, A., Nouaille, M., Akil, H., Petit, D., Labrousse, F., Jauberteau, M., & Mathonnet, M. (2011). Retinoid acid receptors in human colorectal cancer: An unexpected link with patient outcome. Experimental and Therapeutic Medicine, 2, 491-497. https://doi.org/10.3892/etm.2011.242
MLA
Perraud, A., Nouaille, M., Akil, H., Petit, D., Labrousse, F., Jauberteau, M., Mathonnet, M."Retinoid acid receptors in human colorectal cancer: An unexpected link with patient outcome". Experimental and Therapeutic Medicine 2.3 (2011): 491-497.
Chicago
Perraud, A., Nouaille, M., Akil, H., Petit, D., Labrousse, F., Jauberteau, M., Mathonnet, M."Retinoid acid receptors in human colorectal cancer: An unexpected link with patient outcome". Experimental and Therapeutic Medicine 2, no. 3 (2011): 491-497. https://doi.org/10.3892/etm.2011.242
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team