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Article

Cancer stem cell-related factors are associated with the efficacy of pre-operative chemoradiotherapy for locally advanced rectal cancer

  • Authors:
    • Kazuaki Hiroishi
    • Masafumi Inomata
    • Kenji Kashima
    • Kazuhiro Yasuda
    • Norio Shiraishi
    • Shigeo Yokoyama
    • Seigo Kitano
  • View Affiliations / Copyright

    Affiliations: Department of Surgery I, Oita University Faculty of Medicine, Yufu, Oita 879-5593, Japan, Department of Surgery I, Oita University Faculty of Medicine, Yufu, Oita 879-5593, Japan, Department of Diagnostic Pathology, Oita University Faculty of Medicine, Oita 879-5593, Japan
  • Pages: 465-470
    |
    Published online on: March 21, 2011
       https://doi.org/10.3892/etm.2011.243
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Abstract

Pre-operative chemoradiotherapy (CRT) is an important neoadjuvant therapy for locally advanced rectal cancer. In the present study, we investigated the factors that influence the efficacy of pre-operative CRT in locally advanced rectal cancer. We divided 50 patients with locally advanced rectal carcinoma treated with pre-operative CRT into two groups according to the grade of tumor response to pre-operative CRT: low-sensitivity group and high-sensitivity group. As candidates for the prediction of sensitivity to pre-operative CRT, clinicopathological factors and 12 biomarkers, including factors related to tumor growth, cell cycle, apoptosis, tumor stroma and cancer stem cells, were examined immunohistochemically in 48 resected specimens. Thirty-one tumors showed high sensitivity and 19 showed low sensitivity to pre-operative CRT. The status of stem cell-related factors, CD133 and CD24, was significantly associated respectively with sensitivity to pre-operative CRT (P=0.003, P=0.029). In 10 tumors positive for both CD133 and CD24, low sensitivity to CRT was found in 9 (90%), whereas in 16 tumors negative for both CD133 and CD24, low sensitivity was found in 3 (19%). Other pathological parameters were not associated with tumor response to pre-operative CRT. In conclusion, overexpression of cancer stem cell-related factors, CD133 and CD24, is associated with the sensitivity of locally advanced rectal cancer to pre-operative CRT.
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Copy and paste a formatted citation
Spandidos Publications style
Hiroishi K, Inomata M, Kashima K, Yasuda K, Shiraishi N, Yokoyama S and Kitano S: Cancer stem cell-related factors are associated with the efficacy of pre-operative chemoradiotherapy for locally advanced rectal cancer. Exp Ther Med 2: 465-470, 2011.
APA
Hiroishi, K., Inomata, M., Kashima, K., Yasuda, K., Shiraishi, N., Yokoyama, S., & Kitano, S. (2011). Cancer stem cell-related factors are associated with the efficacy of pre-operative chemoradiotherapy for locally advanced rectal cancer. Experimental and Therapeutic Medicine, 2, 465-470. https://doi.org/10.3892/etm.2011.243
MLA
Hiroishi, K., Inomata, M., Kashima, K., Yasuda, K., Shiraishi, N., Yokoyama, S., Kitano, S."Cancer stem cell-related factors are associated with the efficacy of pre-operative chemoradiotherapy for locally advanced rectal cancer". Experimental and Therapeutic Medicine 2.3 (2011): 465-470.
Chicago
Hiroishi, K., Inomata, M., Kashima, K., Yasuda, K., Shiraishi, N., Yokoyama, S., Kitano, S."Cancer stem cell-related factors are associated with the efficacy of pre-operative chemoradiotherapy for locally advanced rectal cancer". Experimental and Therapeutic Medicine 2, no. 3 (2011): 465-470. https://doi.org/10.3892/etm.2011.243
Copy and paste a formatted citation
x
Spandidos Publications style
Hiroishi K, Inomata M, Kashima K, Yasuda K, Shiraishi N, Yokoyama S and Kitano S: Cancer stem cell-related factors are associated with the efficacy of pre-operative chemoradiotherapy for locally advanced rectal cancer. Exp Ther Med 2: 465-470, 2011.
APA
Hiroishi, K., Inomata, M., Kashima, K., Yasuda, K., Shiraishi, N., Yokoyama, S., & Kitano, S. (2011). Cancer stem cell-related factors are associated with the efficacy of pre-operative chemoradiotherapy for locally advanced rectal cancer. Experimental and Therapeutic Medicine, 2, 465-470. https://doi.org/10.3892/etm.2011.243
MLA
Hiroishi, K., Inomata, M., Kashima, K., Yasuda, K., Shiraishi, N., Yokoyama, S., Kitano, S."Cancer stem cell-related factors are associated with the efficacy of pre-operative chemoradiotherapy for locally advanced rectal cancer". Experimental and Therapeutic Medicine 2.3 (2011): 465-470.
Chicago
Hiroishi, K., Inomata, M., Kashima, K., Yasuda, K., Shiraishi, N., Yokoyama, S., Kitano, S."Cancer stem cell-related factors are associated with the efficacy of pre-operative chemoradiotherapy for locally advanced rectal cancer". Experimental and Therapeutic Medicine 2, no. 3 (2011): 465-470. https://doi.org/10.3892/etm.2011.243
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