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Article

Prognostic significance of phosphorylated signal transducer and activator of transcription 3 and suppressor of cytokine signaling 3 expression in hepatocellular carcinoma

  • Authors:
    • Wen-Yong Wu
    • Jun Li
    • Zheng-Sheng Wu
    • Chang-Le Zhang
    • Xiang-Ling Meng
    • Peter E. Lobie
  • View Affiliations / Copyright

    Affiliations: School of Pharmacy, Anhui Medical University, Hefei, Anhui 230032, P.R. China, School of Pharmacy, Anhui Medical University, Hefei, Anhui 230032, P.R. China, Department of Pathology, Anhui Medical University, Hefei, Anhui 230032, P.R. China, Department of General Surgery, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, P.R. China, Cancer Science Institute of Singapore and Department of Pharmacology, National University of Singapore, Singapore
  • Pages: 647-653
    |
    Published online on: April 11, 2011
       https://doi.org/10.3892/etm.2011.254
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Abstract

Altered expression of phosphorylated signal transducer and activator of transcription 3 (pSTAT3) and suppressor of cytokine signaling 3 (SOCS3) has been implicated in various types of human cancers. However, the clinical role of pSTAT3 and SOCS3 in hepatocellular carcinoma (HCC) is not well established. Immunohistochemical analysis of pSTAT3, SOCS3, Ki67 and VEGF expression was performed on tissue microarrays from 138 HCC patients. The expression of STAT3 mRNA was further detected by in situ hybridization. The association of pSTAT3 and SOCS3 expression with clinicopathological factors and patient survival was analyzed. Altered expression of pSTAT3 and SOCS3 was observed in HCC specimens, compared to adjacent non-tumor tissue. Increased expression of pSTAT3 was correlated with large tumor size, higher clinical stage, Ki67 and VEGF expression, as well as poor patient survival. Decreased expression of SOCS3 was correlated with the expression of Ki67, VEGF and pSTAT3, and poor patient survival. Moreover, the expression of pSTAT3 was conversely correlated with SOCS3 expression in HCC. Our results indicate that deregulated expression of pSTAT3 and SOCS3 may play roles in the development and progression of HCC. PSTAT3 and SOCS3 should be further evaluated as potential novel biomarkers for HCC prognosis.
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Copy and paste a formatted citation
Spandidos Publications style
Wu W, Li J, Wu Z, Zhang C, Meng X and Lobie PE: Prognostic significance of phosphorylated signal transducer and activator of transcription 3 and suppressor of cytokine signaling 3 expression in hepatocellular carcinoma. Exp Ther Med 2: 647-653, 2011.
APA
Wu, W., Li, J., Wu, Z., Zhang, C., Meng, X., & Lobie, P.E. (2011). Prognostic significance of phosphorylated signal transducer and activator of transcription 3 and suppressor of cytokine signaling 3 expression in hepatocellular carcinoma. Experimental and Therapeutic Medicine, 2, 647-653. https://doi.org/10.3892/etm.2011.254
MLA
Wu, W., Li, J., Wu, Z., Zhang, C., Meng, X., Lobie, P. E."Prognostic significance of phosphorylated signal transducer and activator of transcription 3 and suppressor of cytokine signaling 3 expression in hepatocellular carcinoma". Experimental and Therapeutic Medicine 2.4 (2011): 647-653.
Chicago
Wu, W., Li, J., Wu, Z., Zhang, C., Meng, X., Lobie, P. E."Prognostic significance of phosphorylated signal transducer and activator of transcription 3 and suppressor of cytokine signaling 3 expression in hepatocellular carcinoma". Experimental and Therapeutic Medicine 2, no. 4 (2011): 647-653. https://doi.org/10.3892/etm.2011.254
Copy and paste a formatted citation
x
Spandidos Publications style
Wu W, Li J, Wu Z, Zhang C, Meng X and Lobie PE: Prognostic significance of phosphorylated signal transducer and activator of transcription 3 and suppressor of cytokine signaling 3 expression in hepatocellular carcinoma. Exp Ther Med 2: 647-653, 2011.
APA
Wu, W., Li, J., Wu, Z., Zhang, C., Meng, X., & Lobie, P.E. (2011). Prognostic significance of phosphorylated signal transducer and activator of transcription 3 and suppressor of cytokine signaling 3 expression in hepatocellular carcinoma. Experimental and Therapeutic Medicine, 2, 647-653. https://doi.org/10.3892/etm.2011.254
MLA
Wu, W., Li, J., Wu, Z., Zhang, C., Meng, X., Lobie, P. E."Prognostic significance of phosphorylated signal transducer and activator of transcription 3 and suppressor of cytokine signaling 3 expression in hepatocellular carcinoma". Experimental and Therapeutic Medicine 2.4 (2011): 647-653.
Chicago
Wu, W., Li, J., Wu, Z., Zhang, C., Meng, X., Lobie, P. E."Prognostic significance of phosphorylated signal transducer and activator of transcription 3 and suppressor of cytokine signaling 3 expression in hepatocellular carcinoma". Experimental and Therapeutic Medicine 2, no. 4 (2011): 647-653. https://doi.org/10.3892/etm.2011.254
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