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Correlation of Kupffer cell function and hepatocyte function in chronic viral hepatitis evaluated with superparamagnetic iron oxide-enhanced magnetic resonance imaging and scintigraphy using technetium-99m-labelled galactosyl human serum albumin

  • Authors:
    • Tatsuyuki Tonan
    • Kiminori Fujimoto
    • Aliya Qayyum
    • Sanae Azuma
    • Masatoshi Ishibashi
    • Takato Ueno
    • Noriyuki Ono
    • Junji Akiyoshi
    • Sunao Matsushita
    • Naofumi Hayabuchi
    • Takumi Kawaguchi
    • Michio Sata
  • View Affiliations / Copyright

    Affiliations: Department of Radiology, Kurume University School of Medicine, Kurume 830-0011, Japan, Department of Radiology and Biomedical Imaging, University of California-San Francisco, San Francisco, CA 94143, USA, Department of Medicine, Kurume University School of Medicine, Kurume 830-0011, Japan, Department of Internal Medicine, Chikugo City Hospital, Chikugo 833-0041, Japan, Internal Medicine, Kamitsu-Chuou Clinic, Kurume 830-0053, Japan, Department of Radiology, Chikugo City Hospital, Chikugo 833-0041, Japan, Department of Digestive Disease Information and Research, Kurume University School of Medicine, Kurume 830-0011, Japan
  • Pages: 607-613
    |
    Published online on: April 11, 2011
       https://doi.org/10.3892/etm.2011.255
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Abstract

Kupffer cells contribute to the pathogenesis of liver injury in chronic liver disease, yet it is difficult to assess Kupffer cell function either ex vivo or in vivo, since supporting data are limited. The aim of this study was to clarify the relation between Kupffer cell function and hepatocyte function by analyzing the correlation between conventional indices of hepatic functional reserve and both superparamagnetic iron oxide-enhanced MRI (SPIO-MRI) and technetium-99m-galactosyl human serum albumin scintigraphy (Tc-99m-GSA) in patients with chronic viral hepatitis. Consecutive 46 patients (16 patients with chronic hepatitis and 30 patients with cirrhosis) who underwent both SPIO-MRI and Tc-99m-GSA were examined. The patients were aged 46-83 years (median 70) and included 29 men and 17 women. Spearman correlation coefficient was used to analyze the correlations between functional reserve indices and both reduction percentages of liver-to-muscle signal intensity ratio (reduction-%LMR), as a surrogate parameter of Kupffer cell function and Tc-99m-GSA parameters. The usefulness of each parameter as a marker to differentiate Child-Pugh A from Child-Pugh B/C was evaluated using receiver operating characteristic (ROC) analysis. The reduction-%LMR correlated more closely with Child-Pugh score (r=0.77; P<0.001) than did Tc-99m-GSA parameters. For predicting Child-Pugh B/C, ROC analysis revealed that reduction-%LMR (AUC=0.91, P<0.001) was the most useful parameter and at a cutoff value of 50% or less, sensitivity, specificity, positive and negative predictive values were 0.79, 0.91, 0.94 and 0.71, respectively. SPIO-MRI may be a helpful non-invasive method for the evaluation of hepatic functional reserve, and this study suggests that Kupffer cell function is closely correlated with hepatocyte function in patients with chronic viral hepatitis.
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1. 

Child CG and Turcotte JG: Surgery and portal hypertension. Major Probl Clin Surg. 1:1–85. 1964.

2. 

Pugh RNH, Murray-Lyon IM, Dawson JL, Pietroni MC and Williams R: Transection of the oesophagus for bleeding oesophageal varices. Br J Surg. 60:646–649. 1973. View Article : Google Scholar : PubMed/NCBI

3. 

Schneider PD: Preoperative assessment of liver function. Surg Clin North Am. 84:355–373. 2004. View Article : Google Scholar

4. 

Lucey MR, Brown KA, Everson GT, et al: Minimal criteria for placement of adults on the liver transplant waiting list. Transplantation. 66:956–962. 1998. View Article : Google Scholar : PubMed/NCBI

5. 

Tygstrup N: The galactose elimination capacity in control subjects and in patients with cirrhosis of the liver. Acta Med Scand. 175:281–289. 1964. View Article : Google Scholar : PubMed/NCBI

6. 

Hepner GW and Vesell ES: Assessment of aminopyrine metabolism in man by breath analysis after oral administration of 14C-aminopyrine. N Engl J Med. 291:134–147. 1975.PubMed/NCBI

7. 

Kawamura H, Kamiyama T, Nakagawa T, et al: Preoperative evaluation of hepatic functional reserve by converted ICGR15 calculated from Tc-GSA scintigraphy. J Gastroenterol Hepatol. 8:1235–1241. 2008. View Article : Google Scholar : PubMed/NCBI

8. 

Moody FG, Rikkers LF and Aldrete JS: Estimation of the functional reserve of human liver. Ann Surg. 180:592–598. 1972. View Article : Google Scholar : PubMed/NCBI

9. 

Yamanaka N, Okamoto E, Kuwata K and Tanaka N: A multiple regression equation for prediction of posthepatectomy liver failure. Ann Surg. 200:658–663. 1984. View Article : Google Scholar : PubMed/NCBI

10. 

Fujioka H, Kawashita Y, Kamohara Y, et al: Utility of technetium-99m-labeled-galactosyl human serum albumin scintigraphy for estimating the hepatic functional reserve. J Clin Gastroenterol. 28:329–333. 1999. View Article : Google Scholar : PubMed/NCBI

11. 

Sasaki N, Shiomi S, Iwata Y, et al: Clinical usefulness of scintigraphy with 99mTc-galactosyl-human serum albumin for prognosis of cirrhosis of the liver. J Nucl Med. 40:1652–1656. 1999.

12. 

Kawamura E, Shiomi S, Ishizu H, et al: Natural course of change in hepatic functional reserve in patients with chronic liver disease evaluated by scintigraphy with GSA. Hepatol Res. 27:129–135. 2003. View Article : Google Scholar : PubMed/NCBI

13. 

Shiomi S, Kuroki T, Kuriyama M, et al: Evaluation of fluminant hepatic failure by scintigraphy with technetium-99m-GSA. J Nucl Med. 38:79–82. 1997.PubMed/NCBI

14. 

Hakawa SK and Tanaka Y: A quantitative model of technetium-99m-DTPA-galactosyl-HSA for the assessment of hepatic blood flow and hepatic binding receptor. J Nucl Med. 32:2233–2240. 1991.PubMed/NCBI

15. 

Sugai Y, Komatani A, Hosoya T and Takahashi K: Analysis of the early blood kinetics of 99mTc-GSA and its verification: new one-compartment model and regression equation. Nucl Med Commun. 22:773–778. 2001. View Article : Google Scholar : PubMed/NCBI

16. 

Sugahara K, Togashi H, Takahashi K, et al: Separate analysis of asialoglycoprotein receptors in the right and left hepatic lobes using Tc-GSA SPECT. Hepatology. 38:1401–1409. 2003.PubMed/NCBI

17. 

Nanashima A, Yamaguchi H, Shibasaki S, et al: Relationship between indocyanine green test and technetium-99m galactosyl serum albumin scintigraphy in patients scheduled for hepatectomy: clinical evaluation and patient outcome. Hepatol Res. 28:184–190. 2004. View Article : Google Scholar

18. 

Tonan T, Fujimoto K, Azuma S, et al: Evaluation of small (< or =2 cm) dysplastic nodules and well-differentiated hepatocellular carcinomas with ferucarbotran-enhanced MRI in a 1.0-T MRI unit: utility of T2-weighted gradient echo sequences with an intermediate-echo time. Eur J Radiol. 64:133–139. 2007.

19. 

Elizondo G, Weissleder R, Stark DD, et al: Hepatic cirrhosis and hepatitis: MR imaging enhanced with superparamagnetic iron oxide. Radiology. 174:797–801. 1990. View Article : Google Scholar : PubMed/NCBI

20. 

Clement O, Frija G, Chambon C, et al: Liver tumors in cirrhosis: experimental study with SPIO-enhanced MR imaging. Radiology. 180:31–36. 1991. View Article : Google Scholar : PubMed/NCBI

21. 

Kato N, Ihara S, Tsujimoto T and Miyazawa T: Effect of resovist on rats with different severities of liver cirrhosis. Invest Radiol. 222:661–666. 2002.PubMed/NCBI

22. 

Tanimoto A, Yuasa Y, Shinmoto H, et al: Superparamagnetic iron oxide-mediated hepatic signal intensity change in patients with and without cirrhosis: pulse sequence effects and Kupffer cell function. Radiology. 222:661–666. 2002. View Article : Google Scholar

23. 

Hundt W, Petsch R, Heimberger T and Reiser H: Signal changes in liver and spleen after Endorem administration in patients with and without liver cirrhosis. Eur Radiol. 10:409–416. 2000. View Article : Google Scholar : PubMed/NCBI

24. 

Gandon Y, Olivié D, Guyader D, et al: Non-invasive assessment of hepatic iron stores by MRI. Lancet. 31:357–362. 2004. View Article : Google Scholar : PubMed/NCBI

25. 

Kudo M, Todo A, Ikekubo K, et al: Functional hepatic imaging with receptor-binding radiopharmaceutical: clinical potential as a measure of functioning hepatocyte mass. Gastroenterol Jpn. 26:734–741. 1991.

26. 

Bland JM and Altman DG: Statistical methods for assessing agreement between two methods of clinical measurement. Lancet. 1:307–310. 1986. View Article : Google Scholar

27. 

Waxman AD: Scintigraphic evaluation of diffuse hepatic disease. Semin Nucl Med. 12:75–88. 1982. View Article : Google Scholar : PubMed/NCBI

28. 

Klingensmith WC III, Fritzberg AR, Zerbe GO and Koep LJ: Relative role of Tc-99m-diethyl-IDA and Tc-99m-sulfur colloid in the evaluation of liver function. Clin Nucl Med. 5:341–346. 1980. View Article : Google Scholar : PubMed/NCBI

29. 

Asanuma T, Ono M, Kubota K, et al: Super paramagnetic iron oxide MRI shows defective Kupffer cell uptake function in non-alcoholic fatty liver disease. Gut. 59:258–266. 2010. View Article : Google Scholar : PubMed/NCBI

30. 

Tsujimoto T, Kawaratani H, Kitazawa T, et al: Decreased phagocytic activity of Kupffer cells in a rat nonalcoholic steatohepatitis model. World J Gastroenterol. 14:6036–6043. 2008. View Article : Google Scholar : PubMed/NCBI

31. 

Kira T, Tomiguchi S, Kira M, Ohyama Y and Takahashi M: Quantitative evaluation of the hepatic functional reserve using technetium-99m DTPA-galactosyl human serum albumin before and after transjugular intrahepatic portosystemic shunt. Eur J Nucl Med. 24:1268–1272. 1997. View Article : Google Scholar

32. 

Osada H, Honda N, Takahashi T, et al: Relationship between (99m)Tc-GSA scintigraphic indices of liver function reserve and portal circulation in patients with chronic liver disease. Ann Nucl Med. 21:245–249. 2007. View Article : Google Scholar : PubMed/NCBI

33. 

Aguirre DA, Behling CA, Alpert E, Hassanein TI and Sirlin CB: Liver fibrosis: noninvasive diagnosis with double contrast material-enhanced MR imaging. Radiology. 239:425–437. 2006. View Article : Google Scholar : PubMed/NCBI

34. 

Lucidarme O, Baleston F, Cadi M, et al: Non-invasive detection of liver fibrosis: Is superparamagnetic iron oxide particle-enhanced MR imaging a contributive technique? Eur Radiol. 13:467–474. 2003.PubMed/NCBI

35. 

Engström-Laurent A, Laurent UB, Lilja K and Laurent TC: Concentration of sodium hyaluronate in serum. Scand J Clin Lab Invest. 45:497–504. 1985.

36. 

Tsukamoto T, Yamamoto T, Ikebe T, et al: Serum markers of liver fibrosis and histologic severity of fibrosis in resected liver. Hepatogastroenterology. 51:777–780. 2004.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Tonan T, Fujimoto K, Qayyum A, Azuma S, Ishibashi M, Ueno T, Ono N, Akiyoshi J, Matsushita S, Hayabuchi N, Hayabuchi N, et al: Correlation of Kupffer cell function and hepatocyte function in chronic viral hepatitis evaluated with superparamagnetic iron oxide-enhanced magnetic resonance imaging and scintigraphy using technetium-99m-labelled galactosyl human serum albumin. Exp Ther Med 2: 607-613, 2011.
APA
Tonan, T., Fujimoto, K., Qayyum, A., Azuma, S., Ishibashi, M., Ueno, T. ... Sata, M. (2011). Correlation of Kupffer cell function and hepatocyte function in chronic viral hepatitis evaluated with superparamagnetic iron oxide-enhanced magnetic resonance imaging and scintigraphy using technetium-99m-labelled galactosyl human serum albumin. Experimental and Therapeutic Medicine, 2, 607-613. https://doi.org/10.3892/etm.2011.255
MLA
Tonan, T., Fujimoto, K., Qayyum, A., Azuma, S., Ishibashi, M., Ueno, T., Ono, N., Akiyoshi, J., Matsushita, S., Hayabuchi, N., Kawaguchi, T., Sata, M."Correlation of Kupffer cell function and hepatocyte function in chronic viral hepatitis evaluated with superparamagnetic iron oxide-enhanced magnetic resonance imaging and scintigraphy using technetium-99m-labelled galactosyl human serum albumin". Experimental and Therapeutic Medicine 2.4 (2011): 607-613.
Chicago
Tonan, T., Fujimoto, K., Qayyum, A., Azuma, S., Ishibashi, M., Ueno, T., Ono, N., Akiyoshi, J., Matsushita, S., Hayabuchi, N., Kawaguchi, T., Sata, M."Correlation of Kupffer cell function and hepatocyte function in chronic viral hepatitis evaluated with superparamagnetic iron oxide-enhanced magnetic resonance imaging and scintigraphy using technetium-99m-labelled galactosyl human serum albumin". Experimental and Therapeutic Medicine 2, no. 4 (2011): 607-613. https://doi.org/10.3892/etm.2011.255
Copy and paste a formatted citation
x
Spandidos Publications style
Tonan T, Fujimoto K, Qayyum A, Azuma S, Ishibashi M, Ueno T, Ono N, Akiyoshi J, Matsushita S, Hayabuchi N, Hayabuchi N, et al: Correlation of Kupffer cell function and hepatocyte function in chronic viral hepatitis evaluated with superparamagnetic iron oxide-enhanced magnetic resonance imaging and scintigraphy using technetium-99m-labelled galactosyl human serum albumin. Exp Ther Med 2: 607-613, 2011.
APA
Tonan, T., Fujimoto, K., Qayyum, A., Azuma, S., Ishibashi, M., Ueno, T. ... Sata, M. (2011). Correlation of Kupffer cell function and hepatocyte function in chronic viral hepatitis evaluated with superparamagnetic iron oxide-enhanced magnetic resonance imaging and scintigraphy using technetium-99m-labelled galactosyl human serum albumin. Experimental and Therapeutic Medicine, 2, 607-613. https://doi.org/10.3892/etm.2011.255
MLA
Tonan, T., Fujimoto, K., Qayyum, A., Azuma, S., Ishibashi, M., Ueno, T., Ono, N., Akiyoshi, J., Matsushita, S., Hayabuchi, N., Kawaguchi, T., Sata, M."Correlation of Kupffer cell function and hepatocyte function in chronic viral hepatitis evaluated with superparamagnetic iron oxide-enhanced magnetic resonance imaging and scintigraphy using technetium-99m-labelled galactosyl human serum albumin". Experimental and Therapeutic Medicine 2.4 (2011): 607-613.
Chicago
Tonan, T., Fujimoto, K., Qayyum, A., Azuma, S., Ishibashi, M., Ueno, T., Ono, N., Akiyoshi, J., Matsushita, S., Hayabuchi, N., Kawaguchi, T., Sata, M."Correlation of Kupffer cell function and hepatocyte function in chronic viral hepatitis evaluated with superparamagnetic iron oxide-enhanced magnetic resonance imaging and scintigraphy using technetium-99m-labelled galactosyl human serum albumin". Experimental and Therapeutic Medicine 2, no. 4 (2011): 607-613. https://doi.org/10.3892/etm.2011.255
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