Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
July-August 2011 Volume 2 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-August 2011 Volume 2 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Formoterol and cancer muscle wasting in rats: Effects on muscle force and total physical activity

  • Authors:
    • Sílvia Busquets
    • Míriam Toledo
    • Sònia Sirisi
    • Marcel Orpí
    • Roberto Serpe
    • Joana  Coutinho
    • Raquel Martínez
    • Josep Μ. Argilés
    • Francisco J. López-Soriano
  • View Affiliations / Copyright

    Affiliations: Cancer Research Group, Departament de Bioquímica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, 08028 Barcelona, Spain, Department of Medical Oncology, University of Cagliari, 09124 Cagliari, Italy
  • Pages: 731-735
    |
    Published online on: April 28, 2011
       https://doi.org/10.3892/etm.2011.260
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Cancer cachexia occurs in the majority of cancer patients before death, and it is responsible for the death of 22% of cancer patients. One of the most relevant characteristics of cachexia is that of asthenia, which reflects significant muscle wasting noted in cachectic cancer patients The aim of the present study was to assess whether the β2-adrenergic agonist formoterol is associated with an improvement in physiological parameters such as grip force and total physical activity in cachetic rats. Administration of the β2-agonist formoterol (0.3 mg/kg for 7 days) in rats bearing Yoshida AH-130 ascites hepatoma tumors, a model which induces a strong loss of both body and muscle weight, resulted in a significant reversal of the muscle wasting process, as reflected by individual muscle weights. The anti-wasting effects of the drug were also observed in terms of total physical activity and grip force, thus resulting in an improvement in physical performance in cachectic tumor-bearing rats.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1. 

Warren S: The immediate causes of death in cancer. Am J Med Sci. 184:610–615. 1932. View Article : Google Scholar

2. 

Argiles JM, Alvarez B and Lopez-Soriano FJ: The metabolic basis of cancer cachexia. Med Res Rev. 17:477–498. 1997. View Article : Google Scholar : PubMed/NCBI

3. 

Argiles JM and Lopez-Soriano FJ: Why do cancer cells have such a high glycolytic rate? Med Hypotheses. 32:151–155. 1990. View Article : Google Scholar : PubMed/NCBI

4. 

Harvey KB, Bothe A Jr and Blackburn GL: Nutritional assessment and patient outcome during oncological therapy. Cancer. 43:2065–2069. 1979. View Article : Google Scholar : PubMed/NCBI

5. 

Nixon DW, Heymsfield SB, Cohen AE, et al: Protein-calorie undernutrition in hospitalized cancer patients. Am J Med. 68:683–690. 1980. View Article : Google Scholar : PubMed/NCBI

6. 

DeWys W: Management of cancer cachexia. Semin Oncol. 12:452–460. 1985.

7. 

Argiles JM, Garcia-Martinez C, Llovera M and Lopez-Soriano FJ: The role of cytokines in muscle wasting: its relation with cancer cachexia. Med Res Rev. 12:637–652. 1992. View Article : Google Scholar : PubMed/NCBI

8. 

Van Royen M, Carbo N, Busquets S, et al: DNA fragmentation occurs in skeletal muscle during tumor growth: a link with cancer cachexia? Biochem Biophys Res Commun. 270:533–537. 2000.PubMed/NCBI

9. 

Kim YS and Sainz RD: Beta-adrenergic agonists and hypertrophy of skeletal muscles. Life Sci. 50:397–407. 1992. View Article : Google Scholar : PubMed/NCBI

10. 

Stock MJ and Rothwell NJ: Effects of beta-adrenergic agonists on metabolism and body composition. Control and Manipulation of Animal Growth. Buttery PJ, Hayes NB and Lindsay DB: Butterworths; London: pp. 249–257. 1985

11. 

Agbenyega ET and Wareham AC: Effect of clenbuterol on skeletal muscle atrophy in mice induced by the glucocorticoid dexamethasone. Comp Biochem Physiol Comp Physiol. 102:141–145. 1992. View Article : Google Scholar : PubMed/NCBI

12. 

Rajab P, Fox J, Riaz S, Tomlinson D, Ball D and Greenhaff PL: Skeletal muscle myosin heavy chain isoforms and energy metabolism after clenbuterol treatment in the rat. Am J Physiol Regul Integr Comp Physiol. 279:R1076–R1081. 2000.PubMed/NCBI

13. 

Hinkle RT, Hodge KM, Cody DB, Sheldon RJ, Kobilka BK and Isfort RJ: Skeletal muscle hypertrophy and anti-atrophy effects of clenbuterol are mediated by the beta2-adrenergic receptor. Muscle Nerve. 25:729–734. 2002. View Article : Google Scholar : PubMed/NCBI

14. 

Wineski LE, von Deutsch DA, Abukhalaf IK, Pitts SA, Potter DE and Paulsen DF: Muscle-specific effects of hindlimb suspension and clenbuterol in mature male rats. Cells Tissues Organs. 171:188–198. 2002. View Article : Google Scholar : PubMed/NCBI

15. 

Yang YT and McElligott MA: Multiple actions of beta-adrenergic agonists on skeletal muscle and adipose tissue. Biochem J. 261:1–10. 1989.PubMed/NCBI

16. 

Mersmann HJ: Overview of the effects of beta-adrenergic receptor agonists on animal growth including mechanisms of action. J Anim Sci. 76:160–172. 1998.PubMed/NCBI

17. 

Anderson GP: Pharmacology of formoterol: an innovative bronchodilator. Agents Actions Suppl. 34:97–115. 1991.PubMed/NCBI

18. 

Mahler DA: The effect of inhaled beta2-agonists on clinical outcomes in chronic obstructive pulmonary disease. J Allergy Clin Immunol. 110:S298–S303. 2002. View Article : Google Scholar : PubMed/NCBI

19. 

Busquets S, Figueras MT, Fuster G, et al: Anticachectic effects of formoterol: a drug for potential treatment of muscle wasting. Cancer Res. 64:6725–6731. 2004. View Article : Google Scholar : PubMed/NCBI

20. 

Tessitore L, Costelli P, Bonetti G and Baccino FM: Cancer cachexia, malnutrition, and tissue protein turnover in experimental animals. Arch Biochem Biophys. 306:52–58. 1993. View Article : Google Scholar : PubMed/NCBI

21. 

Sinis N, Guntinas-Lichius O, Irintchev A, et al: Manual stimulation of forearm muscles does not improve recovery of motor function after injury to a mixed peripheral nerve. Exp Brain Res. 185:469–483. 2008. View Article : Google Scholar : PubMed/NCBI

22. 

Zangarelli A, Chanseaume E, Morio B, et al: Synergistic effects of caloric restriction with maintained protein intake on skeletal muscle performance in 21-month-old rats: a mitochondria-mediated pathway. FASEB J. 20:2439–2450. 2006. View Article : Google Scholar

23. 

Fuster G, Busquets S, Ametller E, et al: Are peroxisome proliferator-activated receptors involved in skeletal muscle wasting during experimental cancer cachexia? Role of beta2-adrenergic agonists. Cancer Res. 67:6512–6519. 2007. View Article : Google Scholar

24. 

Costelli P, Garcia-Martinez C, Llovera M, et al: Muscle protein waste in tumor-bearing rats is effectively antagonized by a beta 2-adrenergic agonist (clenbuterol). Role of the ATP-ubiquitin-dependent proteolytic pathway. J Clin Invest. 95:2367–2372. 1995. View Article : Google Scholar

25. 

Ametller E, Busquets S, Fuster G, et al: Formoterol may activate rat muscle regeneration during cancer cachexia. Insciences J. 1:1–17. 2011. View Article : Google Scholar

26. 

Lanigan C, Howes TQ, Borzone G, Vianna LG and Moxham J: The effects of beta 2-agonists and caffeine on respiratory and limb muscle performance. Eur Respir J. 6:1192–1196. 1993.PubMed/NCBI

27. 

Signorile JF, Banovac K, Gomez M, Flipse D, Caruso JF and Lowensteyn I: Increased muscle strength in paralyzed patients after spinal cord injury: effect of beta-2 adrenergic agonist. Arch Phys Med Rehabil. 76:55–58. 1995. View Article : Google Scholar : PubMed/NCBI

28. 

Marzabal M, Garcia-Martinez C, Comas J, Lopez-Soriano FJ and Argiles JM: A flow cytometric study of the rat Yoshida AH-130 ascites hepatoma. Cancer Lett. 72:169–173. 1993. View Article : Google Scholar : PubMed/NCBI

29. 

Toledo M, Busquets S, Sirisi S, et al: Cancer cachexia: physical activity and muscle force in tumour-bearing rats. Oncol Rep. 25:189–193. 2011.PubMed/NCBI

30. 

Argiles JM, Busquets S, Toledo M and Lopez-Soriano FJ: The role of cytokines in cancer cachexia. Curr Opin Support Palliat Care. 3:263–268. 2009. View Article : Google Scholar

31. 

Llovera M, Garcia-Martinez C, Lopez-Soriano J, et al: Role of TNF receptor 1 in protein turnover during cancer cachexia using gene knockout mice. Mol Cell Endocrinol. 142:183–189. 1998. View Article : Google Scholar : PubMed/NCBI

32. 

Argiles JM, Busquets S and Lopez-Soriano FJ: Cytokines as mediators and targets for cancer cachexia. Cancer Treat Res. 130:199–217. 2006. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Busquets S, Toledo M, Sirisi S, Orpí M, Serpe R, Coutinho J, Martínez R, Argilés JΜ and López-Soriano FJ: Formoterol and cancer muscle wasting in rats: Effects on muscle force and total physical activity. Exp Ther Med 2: 731-735, 2011.
APA
Busquets, S., Toledo, M., Sirisi, S., Orpí, M., Serpe, R., Coutinho, J. ... López-Soriano, F.J. (2011). Formoterol and cancer muscle wasting in rats: Effects on muscle force and total physical activity. Experimental and Therapeutic Medicine, 2, 731-735. https://doi.org/10.3892/etm.2011.260
MLA
Busquets, S., Toledo, M., Sirisi, S., Orpí, M., Serpe, R., Coutinho, J., Martínez, R., Argilés, J. Μ., López-Soriano, F. J."Formoterol and cancer muscle wasting in rats: Effects on muscle force and total physical activity". Experimental and Therapeutic Medicine 2.4 (2011): 731-735.
Chicago
Busquets, S., Toledo, M., Sirisi, S., Orpí, M., Serpe, R., Coutinho, J., Martínez, R., Argilés, J. Μ., López-Soriano, F. J."Formoterol and cancer muscle wasting in rats: Effects on muscle force and total physical activity". Experimental and Therapeutic Medicine 2, no. 4 (2011): 731-735. https://doi.org/10.3892/etm.2011.260
Copy and paste a formatted citation
x
Spandidos Publications style
Busquets S, Toledo M, Sirisi S, Orpí M, Serpe R, Coutinho J, Martínez R, Argilés JΜ and López-Soriano FJ: Formoterol and cancer muscle wasting in rats: Effects on muscle force and total physical activity. Exp Ther Med 2: 731-735, 2011.
APA
Busquets, S., Toledo, M., Sirisi, S., Orpí, M., Serpe, R., Coutinho, J. ... López-Soriano, F.J. (2011). Formoterol and cancer muscle wasting in rats: Effects on muscle force and total physical activity. Experimental and Therapeutic Medicine, 2, 731-735. https://doi.org/10.3892/etm.2011.260
MLA
Busquets, S., Toledo, M., Sirisi, S., Orpí, M., Serpe, R., Coutinho, J., Martínez, R., Argilés, J. Μ., López-Soriano, F. J."Formoterol and cancer muscle wasting in rats: Effects on muscle force and total physical activity". Experimental and Therapeutic Medicine 2.4 (2011): 731-735.
Chicago
Busquets, S., Toledo, M., Sirisi, S., Orpí, M., Serpe, R., Coutinho, J., Martínez, R., Argilés, J. Μ., López-Soriano, F. J."Formoterol and cancer muscle wasting in rats: Effects on muscle force and total physical activity". Experimental and Therapeutic Medicine 2, no. 4 (2011): 731-735. https://doi.org/10.3892/etm.2011.260
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team