Association of a polymorphism of BTN2A1 with dyslipidemia in East Asian populations

Fujimaki,Tetsuo; Kato,Kimihiko; Oguri,Mitsutoshi; Yohida,Tetsuro; Horibe,Hideki; Yokoi,Kiyoshi; Watanabe,Sachiro; Satoh,Kei; Aoyagi,Yukitoshi; Tanaka,Masashi; Yoshida,Hiroto; Shinkai,Shoji; Nozawa,Yoshinori; Shin,Dong-Jik; Lee,Jong-Ho; Jang,Yangsoo; Yamada,Yoshiji

doi:10.3892/etm.2011.266

July-August 2011 Volume 2 Issue 4

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July-August 2011 Volume 2 Issue 4

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Article

Association of a polymorphism of BTN2A1 with dyslipidemia in East Asian populations

Authors:
- Tetsuo Fujimaki
- Kimihiko Kato
- Mitsutoshi Oguri
- Tetsuro Yohida
- Hideki Horibe
- Kiyoshi Yokoi
- Sachiro Watanabe
- Kei Satoh
- Yukitoshi Aoyagi
- Masashi Tanaka
- Hiroto Yoshida
- Shoji Shinkai
- Yoshinori Nozawa
- Dong-Jik Shin
- Jong-Ho Lee
- Yangsoo Jang
- Yoshiji Yamada
View Affiliations / Copyright

Affiliations: Department of Cardiovascular Medicine, Inabe General Hospital, Inabe, Japan, Meitoh Hospital, Nagoya and Life Science Research Center, Mie University, Tsu, Japan, Department of Cardiology, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan, Department of Cardiovascular Medicine, Gifu Prefectural Tajimi Hospital, Tajimi, Japan, Department of Cardiology, Gifu Prefectural General Medical Center, Gifu, Japan, Department of Vascular Biology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Hirosaki, Japan, Department of Genomics for Longevity and Health, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan, Research Team for Social Participation and Health Promotion, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan, Gifu International Institute of Biotechnology and Tokai Gakuin University, Kakamigahara, Japan, Research Institute of Science for Aging, College of Medicine, Yonsei University, Seoul, Republic of Korea, Cardiology Division, Cardiovascular Center and Cardiovascular Genome Center, College of Medicine, Yonsei University, Seoul, Republic of Korea, Department of Human Functional Genomics, Life Science Research Center, Mie University, Tsu, Mie 514-8507, Japan
Pages: 745-749
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Published online on: May 12, 2011

https://doi.org/10.3892/etm.2011.266
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Abstract

We previously identified rs6929846 of the butyrophilin, subfamily 2, member A1 gene (BTN2A1) as a susceptibility locus for myocardial infarction in Japanese individuals by a genome-wide association study. The aim of the present study was to examine the relation of the rs6929846 polymorphism of BTN2A1 to dyslipidemia in Japanese and Korean populations, given that dyslipidemia is an important risk factor for myocardial infarction. A total of 10,953 individuals from three independent subject panels were examined. The relations of the rs6929846 polymorphism of BTN2A1 to serum concentrations of triglycerides, high-density lipoprotein (HDL)-cholesterol and low-density lipoprotein (LDL)-cholesterol were examined in each subject panel. The C→T polymorphism (rs6929846) of BTN2A1 was significantly associated with serum concentrations of triglycerides in Japanese subject panels A (P=0.0004) and B (P=0.0010), and in the Korean population (P=0.0095), with the minor T allele being related to an increased serum concentration of triglycerides. The rs6929846 was associated with serum concentrations of HDL-cholesterol in Japanese subject panels A (P=0.0047) and B (P=0.0015), with the T allele being related to a decreased serum concentration of HDL-cholesterol, but not in the Korean population. This polymorphism was associated with the serum concentration of LDL-cholesterol only in Japanese subject panel B (P=0.0059), with the T allele being related to an increased serum concentration of LDL-cholesterol. The results suggest that BTN2A1 may be a susceptibility gene for hypertriglyceridemia in East Asian populations and for low serum HDL-cholesterol in the Japanese population.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Association of a polymorphism of BTN2A1 with dyslipidemia in East Asian populations

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