Significance of aldehyde dehydrogenase 1 expression in stromal cells of diffuse large B-cell lymphoma

  • Authors:
    • Shigeki Fujita
    • Eiichi Morii
    • Nur Rahadiani
    • Naoki Wada
    • Yumiko Hori
    • Jun-Ichiro Ikeda
    • Katsuyuki Aozasa
  • View Affiliations

  • Published online on: May 12, 2011     https://doi.org/10.3892/etm.2011.269
  • Pages: 591-594
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Abstract

Aldehyde dehydrogenase (ALDH) 1 is expressed in various stem/progenitor cells, including cancer-initiating cells (CICs). In the present study, ALDH1 expression was immunohistochemically examined in diffuse large B-cell lymphoma (DLBCL). Unexpectedly, ALDH1 expression was occasionally detected in stromal cells, but not in lymphoma cells. Positively stained cells were CD68+ cells with voluminous cytoplasm and fascin+ cells with reticular morphology, designated as macrophages and dendritic cells (DCs), respectively. The presence of ALDH1+ macrophages was not correlated with stage, response to therapies and prognosis. However, cases with ALDH1+ DCs were mostly nodal, which showed a poorer response to therapies and a worse overall survival rate than cases without ALDH1+ DCs. The presence of ALDH1+ DCs appears to be involved in the malignant potential of DLBCL in lymph node.
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July-August 2011
Volume 2 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Fujita S, Morii E, Rahadiani N, Wada N, Hori Y, Ikeda J and Aozasa K: Significance of aldehyde dehydrogenase 1 expression in stromal cells of diffuse large B-cell lymphoma. Exp Ther Med 2: 591-594, 2011
APA
Fujita, S., Morii, E., Rahadiani, N., Wada, N., Hori, Y., Ikeda, J., & Aozasa, K. (2011). Significance of aldehyde dehydrogenase 1 expression in stromal cells of diffuse large B-cell lymphoma. Experimental and Therapeutic Medicine, 2, 591-594. https://doi.org/10.3892/etm.2011.269
MLA
Fujita, S., Morii, E., Rahadiani, N., Wada, N., Hori, Y., Ikeda, J., Aozasa, K."Significance of aldehyde dehydrogenase 1 expression in stromal cells of diffuse large B-cell lymphoma". Experimental and Therapeutic Medicine 2.4 (2011): 591-594.
Chicago
Fujita, S., Morii, E., Rahadiani, N., Wada, N., Hori, Y., Ikeda, J., Aozasa, K."Significance of aldehyde dehydrogenase 1 expression in stromal cells of diffuse large B-cell lymphoma". Experimental and Therapeutic Medicine 2, no. 4 (2011): 591-594. https://doi.org/10.3892/etm.2011.269