Significance of aldehyde dehydrogenase 1 expression in stromal cells of diffuse large B-cell lymphoma

Fujita,Shigeki; Morii,Eiichi; Rahadiani,Nur; Wada,Naoki; Hori,Yumiko; Ikeda,Jun-Ichiro; Aozasa,Katsuyuki

doi:10.3892/etm.2011.269

July-August 2011 Volume 2 Issue 4

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July-August 2011 Volume 2 Issue 4

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Article

Significance of aldehyde dehydrogenase 1 expression in stromal cells of diffuse large B-cell lymphoma

Authors:
- Shigeki Fujita
- Eiichi Morii
- Nur Rahadiani
- Naoki Wada
- Yumiko Hori
- Jun-Ichiro Ikeda
- Katsuyuki Aozasa
View Affiliations / Copyright

Affiliations: Department of Pathology, Osaka University Graduate School of Medicine, Suita 565-0871, Japan
Pages: 591-594
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Published online on: May 12, 2011

https://doi.org/10.3892/etm.2011.269
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Abstract

Aldehyde dehydrogenase (ALDH) 1 is expressed in various stem/progenitor cells, including cancer-initiating cells (CICs). In the present study, ALDH1 expression was immunohistochemically examined in diffuse large B-cell lymphoma (DLBCL). Unexpectedly, ALDH1 expression was occasionally detected in stromal cells, but not in lymphoma cells. Positively stained cells were CD68+ cells with voluminous cytoplasm and fascin+ cells with reticular morphology, designated as macrophages and dendritic cells (DCs), respectively. The presence of ALDH1+ macrophages was not correlated with stage, response to therapies and prognosis. However, cases with ALDH1+ DCs were mostly nodal, which showed a poorer response to therapies and a worse overall survival rate than cases without ALDH1+ DCs. The presence of ALDH1+ DCs appears to be involved in the malignant potential of DLBCL in lymph node.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Significance of aldehyde dehydrogenase 1 expression in stromal cells of diffuse large B-cell lymphoma

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