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Review

Potential of edaravone for neuroprotection in neurologic diseases that do not involve cerebral infarction (Review)

  • Authors:
    • Kiyoshi Kikuchi
    • Ko-ichi Kawahara
    • Hisaaki Uchikado
    • Naohisa Miyagi
    • Terukazu Kuramoto
    • Tomoya Miyagi
    • Yoko Morimoto
    • Takashi Ito
    • Salunya Tancharoen
    • Naoki Miura
    • Kazunori Takenouchi
    • Yoko Oyama
    • Binita Shrestha
    • Fumiyo Matsuda
    • Yoshihiro Yoshida
    • Shinihiro Arimura
    • Kentaro Mera
    • Ko-ichi Tada
    • Narimasa Yoshinaga
    • Ryuichi Maenosono
    • Yoshiko Ohno
    • Teruto Hashiguchi
    • Ikuro Maruyama
    • Minoru Shigemori
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Yame Public General Hospital, Yame 834-0034, Japan, Division of Laboratory and Vascular Medicine, Field of Cardiovascular and Respiratory Disorders, Department of Advanced Therapeutics, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8520, Japan, Department of Neurosurgery, Kurume University School of Medicine, Kurume 830-0011, Japan, Department of Neurosurgery, Yame Public General Hospital, Yame 834-0034, Japan, Department of Neurosurgery, Omuta City General Hospital, Fukuoka 836‑8567, Japan, Department of Restorative Dentistry and Endodontology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8544, Japan, Department of Pharmacology, Faculty of Dentistry, Mahidol University, Bangkok 10400, Thailand, Veterinary Teaching Hospital and Laboratory of Veterinary Diagnostic Imaging, Faculty of Agriculture, Kagoshima University, Kagoshima 890-0065, Japan, Division of Physical Therapy, School of Health Sciences, Faculty of Medicine, Kagoshima University, Kagoshima 890-8506, Japan, Division of Physical Therapy, School of Health Sciences, Faculty of Medicine, Kagoshima University, Kagoshima 890-8506, Japan, Department of Maxillofacial Diagnostic and Surgical Science, Field of Oral and Maxillofacial Rehabilitation, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890‑8520, Japan, Department of Dermatology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890‑8520, Japan, Department of Dermatology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890‑8520, Japan, Department of Neurosurgery, Kurume University School of Medicine, Kurume 830-0011, Japan
  • Pages: 771-775
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    Published online on: June 7, 2011
       https://doi.org/10.3892/etm.2011.281
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Abstract

Edaravone was originally developed as a potent free radical scavenger and has been widely used to treat cerebral infarction in Japan since 2001. Several free radical scavengers have been developed and some of them have progressed to clinical trials for the treatment of cerebral infarction. One such scavenger, edaravone, has been approved by the regulatory authority in Japan for the treatment of patients with cerebral infarction. Of particular interest is the ability of edaravone to diffuse into the central nervous system in various neurologic diseases. Aside from its hydroxyl radical scavenging effect, edaravone has been found to have beneficial effects on inflammation, matrix metalloproteinases, nitric oxide production and apoptotic cell death. Concordantly, edaravone has been found to have neuroprotective effects in a number of animal models of disease, including stroke, spinal cord injury, traumatic brain injury, neurodegenerative diseases and brain tumors. The proven safety of edaravone following 9 years of use as a free radical scavenger suggests that it may have potential for development into an effective treatment of multiple neurologic conditions in humans.
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Copy and paste a formatted citation
Spandidos Publications style
Kikuchi K, Kawahara K, Uchikado H, Miyagi N, Kuramoto T, Miyagi T, Morimoto Y, Ito T, Tancharoen S, Miura N, Miura N, et al: Potential of edaravone for neuroprotection in neurologic diseases that do not involve cerebral infarction (Review). Exp Ther Med 2: 771-775, 2011.
APA
Kikuchi, K., Kawahara, K., Uchikado, H., Miyagi, N., Kuramoto, T., Miyagi, T. ... Shigemori, M. (2011). Potential of edaravone for neuroprotection in neurologic diseases that do not involve cerebral infarction (Review). Experimental and Therapeutic Medicine, 2, 771-775. https://doi.org/10.3892/etm.2011.281
MLA
Kikuchi, K., Kawahara, K., Uchikado, H., Miyagi, N., Kuramoto, T., Miyagi, T., Morimoto, Y., Ito, T., Tancharoen, S., Miura, N., Takenouchi, K., Oyama, Y., Shrestha, B., Matsuda, F., Yoshida, Y., Arimura, S., Mera, K., Tada, K., Yoshinaga, N., Maenosono, R., Ohno, Y., Hashiguchi, T., Maruyama, I., Shigemori, M."Potential of edaravone for neuroprotection in neurologic diseases that do not involve cerebral infarction (Review)". Experimental and Therapeutic Medicine 2.5 (2011): 771-775.
Chicago
Kikuchi, K., Kawahara, K., Uchikado, H., Miyagi, N., Kuramoto, T., Miyagi, T., Morimoto, Y., Ito, T., Tancharoen, S., Miura, N., Takenouchi, K., Oyama, Y., Shrestha, B., Matsuda, F., Yoshida, Y., Arimura, S., Mera, K., Tada, K., Yoshinaga, N., Maenosono, R., Ohno, Y., Hashiguchi, T., Maruyama, I., Shigemori, M."Potential of edaravone for neuroprotection in neurologic diseases that do not involve cerebral infarction (Review)". Experimental and Therapeutic Medicine 2, no. 5 (2011): 771-775. https://doi.org/10.3892/etm.2011.281
Copy and paste a formatted citation
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Spandidos Publications style
Kikuchi K, Kawahara K, Uchikado H, Miyagi N, Kuramoto T, Miyagi T, Morimoto Y, Ito T, Tancharoen S, Miura N, Miura N, et al: Potential of edaravone for neuroprotection in neurologic diseases that do not involve cerebral infarction (Review). Exp Ther Med 2: 771-775, 2011.
APA
Kikuchi, K., Kawahara, K., Uchikado, H., Miyagi, N., Kuramoto, T., Miyagi, T. ... Shigemori, M. (2011). Potential of edaravone for neuroprotection in neurologic diseases that do not involve cerebral infarction (Review). Experimental and Therapeutic Medicine, 2, 771-775. https://doi.org/10.3892/etm.2011.281
MLA
Kikuchi, K., Kawahara, K., Uchikado, H., Miyagi, N., Kuramoto, T., Miyagi, T., Morimoto, Y., Ito, T., Tancharoen, S., Miura, N., Takenouchi, K., Oyama, Y., Shrestha, B., Matsuda, F., Yoshida, Y., Arimura, S., Mera, K., Tada, K., Yoshinaga, N., Maenosono, R., Ohno, Y., Hashiguchi, T., Maruyama, I., Shigemori, M."Potential of edaravone for neuroprotection in neurologic diseases that do not involve cerebral infarction (Review)". Experimental and Therapeutic Medicine 2.5 (2011): 771-775.
Chicago
Kikuchi, K., Kawahara, K., Uchikado, H., Miyagi, N., Kuramoto, T., Miyagi, T., Morimoto, Y., Ito, T., Tancharoen, S., Miura, N., Takenouchi, K., Oyama, Y., Shrestha, B., Matsuda, F., Yoshida, Y., Arimura, S., Mera, K., Tada, K., Yoshinaga, N., Maenosono, R., Ohno, Y., Hashiguchi, T., Maruyama, I., Shigemori, M."Potential of edaravone for neuroprotection in neurologic diseases that do not involve cerebral infarction (Review)". Experimental and Therapeutic Medicine 2, no. 5 (2011): 771-775. https://doi.org/10.3892/etm.2011.281
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