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Article

microRNA-101 inhibits lung cancer invasion through the regulation of enhancer of zeste homolog 2

  • Authors:
    • Hyun Min Cho
    • Hyo Sung Jeon
    • Soo Young Lee
    • Kang Jin Jeong
    • Soon-Young Park
    • Hoi Young Lee
    • Jung Uee Lee
    • Ji hye Kim
    • Sun Jung Kwon
    • Eugene Choi
    • Moon Jun Na
    • Jaeku Kang
    • Ji Woong Son
  • View Affiliations / Copyright

    Affiliations: Department of Thoracic Surgery, Konyang University Hospital, Daejeon 302-718, Republic of Korea, Department of Biochemistry, School of Medicine, Kyungpook National University, Daegu 700-422, Republic of Korea, Myunggok Research Institute for Medical Science, Konyang University, Daejeon 302-718, Republic of Korea, Department of Pharmacology, College of Medicine, Konyang University, Daejeon 302-718, Republic of Korea, Department of Hospital Pathology, The Catholic University of Korea, Daejeon St. Mary's Hospital, Daejeon 301-723, Republic of Korea, Department of Internal Medicine, Konyang University Hospital, Daejeon 302-718, Republic of Korea
  • Pages: 963-967
    |
    Published online on: June 14, 2011
       https://doi.org/10.3892/etm.2011.284
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Abstract

microRNAs (miRNAs) may function as oncogenes or tumor-suppressor genes depending on the targets that are regulated. Enhancer of zeste homolog 2 (EZH2) is the target of miR-101 and a member of the polycomb repressive complex 2, which is involved in the methylation of histone H3 at lysine 27 (H3K27). Therefore, we aimed to ascertain whether or not the overexpression of miR-101 inhibits invasion of lung cancer through regulation of EZH2. In this study, the expression of miR-101 was down-regulated and the expression of EZH2 was up-regulated in lung cancer. Global methylation of H3K27 was higher in metastatic lung cancer than in early lung cancer lesions. Overexpression of miR-101 induced a marked reduction in EZH2 mRNA levels in several lung cancer cell lines. A reduction in the trimethyl H3K27 histone mark was detected at the CDH1 promoter in miR-101 precursor-transfected cells. Moreover, the expression of CDH1 and MMP-2 was reversed by miR-101 transfection. Therefore, the overexpression of miR-101 inhibits the invasiveness of lung cancer. miR-101 may be a potent tumor suppressor by altering chromatin structure through repression of EZH2 and may be a potential therapeutic tool for patients with lung cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Cho H, Jeon H, Lee S, Jeong K, Park S, Lee H, Lee J, Kim J, Kwon S, Choi E, Choi E, et al: microRNA-101 inhibits lung cancer invasion through the regulation of enhancer of zeste homolog 2. Exp Ther Med 2: 963-967, 2011.
APA
Cho, H., Jeon, H., Lee, S., Jeong, K., Park, S., Lee, H. ... Son, J. (2011). microRNA-101 inhibits lung cancer invasion through the regulation of enhancer of zeste homolog 2. Experimental and Therapeutic Medicine, 2, 963-967. https://doi.org/10.3892/etm.2011.284
MLA
Cho, H., Jeon, H., Lee, S., Jeong, K., Park, S., Lee, H., Lee, J., Kim, J., Kwon, S., Choi, E., Na, M., Kang, J., Son, J."microRNA-101 inhibits lung cancer invasion through the regulation of enhancer of zeste homolog 2". Experimental and Therapeutic Medicine 2.5 (2011): 963-967.
Chicago
Cho, H., Jeon, H., Lee, S., Jeong, K., Park, S., Lee, H., Lee, J., Kim, J., Kwon, S., Choi, E., Na, M., Kang, J., Son, J."microRNA-101 inhibits lung cancer invasion through the regulation of enhancer of zeste homolog 2". Experimental and Therapeutic Medicine 2, no. 5 (2011): 963-967. https://doi.org/10.3892/etm.2011.284
Copy and paste a formatted citation
x
Spandidos Publications style
Cho H, Jeon H, Lee S, Jeong K, Park S, Lee H, Lee J, Kim J, Kwon S, Choi E, Choi E, et al: microRNA-101 inhibits lung cancer invasion through the regulation of enhancer of zeste homolog 2. Exp Ther Med 2: 963-967, 2011.
APA
Cho, H., Jeon, H., Lee, S., Jeong, K., Park, S., Lee, H. ... Son, J. (2011). microRNA-101 inhibits lung cancer invasion through the regulation of enhancer of zeste homolog 2. Experimental and Therapeutic Medicine, 2, 963-967. https://doi.org/10.3892/etm.2011.284
MLA
Cho, H., Jeon, H., Lee, S., Jeong, K., Park, S., Lee, H., Lee, J., Kim, J., Kwon, S., Choi, E., Na, M., Kang, J., Son, J."microRNA-101 inhibits lung cancer invasion through the regulation of enhancer of zeste homolog 2". Experimental and Therapeutic Medicine 2.5 (2011): 963-967.
Chicago
Cho, H., Jeon, H., Lee, S., Jeong, K., Park, S., Lee, H., Lee, J., Kim, J., Kwon, S., Choi, E., Na, M., Kang, J., Son, J."microRNA-101 inhibits lung cancer invasion through the regulation of enhancer of zeste homolog 2". Experimental and Therapeutic Medicine 2, no. 5 (2011): 963-967. https://doi.org/10.3892/etm.2011.284
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