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Article

Investigation of the protective effect of erythropoietin on spinal cord injury in rats

  • Authors:
    • Zhenghua Hong
    • Huaxing Hong
    • Haixiao Chen
    • Zhangfu Wang
    • Dun Hong
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics, Taizhou Hospital of Zhejiang Province, Taizhou 317000, P.R. China
  • Pages: 837-841
    |
    Published online on: June 14, 2011
       https://doi.org/10.3892/etm.2011.285
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Abstract

Erythropoietin (EPO) is a promising therapeutic agent used in a variety of spinal cord injuries. Therefore, identifying the specific molecular pathway mediating the neuronal protective effect of EPO after spinal cord injury (SCI) is of great value to the patients concerned. Platelet-derived growth factor (PDGF)-B is an important factor in the recovery of neurological function. We explored changes in the expression of PDGF-B in spinal cord injury rats after receiving EPO treatment. We used a weight-drop contusion SCI model, and EPO treatment group rats received single doses ofEPO (1,000 U/kg i.p.) immediately after the operation. Seven days after the operation, the results revealed a more rapid recovery as noted by the higher BBB scores, less disruption and more neuronal regeneration of the spinal cord in the EPO treatment group than that in the SCI group. PDGF-B expression also increased in the EPO treatment group compared to that in the SCI group (P<0.01). This study showed that PDGF-B plays a role in the neuronal protective effect of EPO on spinal cord injury in rats, which may help to explain the quick recovery after EPO treatment of spinal cord injury.
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Copy and paste a formatted citation
Spandidos Publications style
Hong Z, Hong H, Chen H, Wang Z and Hong D: Investigation of the protective effect of erythropoietin on spinal cord injury in rats. Exp Ther Med 2: 837-841, 2011.
APA
Hong, Z., Hong, H., Chen, H., Wang, Z., & Hong, D. (2011). Investigation of the protective effect of erythropoietin on spinal cord injury in rats. Experimental and Therapeutic Medicine, 2, 837-841. https://doi.org/10.3892/etm.2011.285
MLA
Hong, Z., Hong, H., Chen, H., Wang, Z., Hong, D."Investigation of the protective effect of erythropoietin on spinal cord injury in rats". Experimental and Therapeutic Medicine 2.5 (2011): 837-841.
Chicago
Hong, Z., Hong, H., Chen, H., Wang, Z., Hong, D."Investigation of the protective effect of erythropoietin on spinal cord injury in rats". Experimental and Therapeutic Medicine 2, no. 5 (2011): 837-841. https://doi.org/10.3892/etm.2011.285
Copy and paste a formatted citation
x
Spandidos Publications style
Hong Z, Hong H, Chen H, Wang Z and Hong D: Investigation of the protective effect of erythropoietin on spinal cord injury in rats. Exp Ther Med 2: 837-841, 2011.
APA
Hong, Z., Hong, H., Chen, H., Wang, Z., & Hong, D. (2011). Investigation of the protective effect of erythropoietin on spinal cord injury in rats. Experimental and Therapeutic Medicine, 2, 837-841. https://doi.org/10.3892/etm.2011.285
MLA
Hong, Z., Hong, H., Chen, H., Wang, Z., Hong, D."Investigation of the protective effect of erythropoietin on spinal cord injury in rats". Experimental and Therapeutic Medicine 2.5 (2011): 837-841.
Chicago
Hong, Z., Hong, H., Chen, H., Wang, Z., Hong, D."Investigation of the protective effect of erythropoietin on spinal cord injury in rats". Experimental and Therapeutic Medicine 2, no. 5 (2011): 837-841. https://doi.org/10.3892/etm.2011.285
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