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Experimental and Therapeutic Medicine
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Print ISSN: 1792-0981 Online ISSN: 1792-1015
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September-October 2011 Volume 2 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Overexpression of activating transcription factor 5 in human rectal cancer

  • Authors:
    • XiangHeng Kong
    • Wenjian Meng
    • ZongGuang Zhou
    • Yuan Li
    • Bin Zhou
    • Rong Wang
    • Lan Zhan

  • View Affiliations / Copyright

    Affiliations: Institute of Digestive Surgery, West China Hospital, Sichuan 610041, P.R. China, Institute of Digestive Surgery and Department of Gastrointestinal Surgery, West China Hospital, Sichuan 610041, P.R. China, Department of Pathology, West China Hospital, Sichuan 610041, P.R. China
  • Pages: 827-831
    |
    Published online on: June 27, 2011
       https://doi.org/10.3892/etm.2011.295
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Abstract

The aim of this study was to investigate the relationship between the expression of activating transcription factor 5 (ATF5) and clinicopathological features in human rectal cancer. Relative quantitative real-time RT-PCR and immunohistochemical staining were used to detect ATF5 mRNA and protein expression in 92 paired samples of rectal cancer and distant normal tissues. Immunohistochemical staining of the matched rectal tissue samples revealed that the positive expression rate of the ATF5 protein in rectal cancer was significantly higher compared to that in the normal tissue. Furthermore, the expression of ATF5 in poorly differentiated cancers was higher compared to that in well to moderately differentiated cancers (P=0.013). However, there was no significant association between ATF5 protein expression and patient age, gender, histological tumor type, cell differentiation, invasive depth, lymph node metastasis or distant metastasis (P>0.05). However, to our surprise, there was no difference in the relative mRNA expression levels of ATF5 between normal tissues and rectal cancers. Our findings indicate that overexpression of ATF5 protein may be an important biomarker of the degree of malignancy, and increased expression may be related to the post-transcriptional regulation of ATF5 in rectal cancer tissues.

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Copy and paste a formatted citation
Spandidos Publications style
Kong X, Meng W, Zhou Z, Li Y, Zhou B, Wang R and Zhan L: Overexpression of activating transcription factor 5 in human rectal cancer. Exp Ther Med 2: 827-831, 2011.
APA
Kong, X., Meng, W., Zhou, Z., Li, Y., Zhou, B., Wang, R., & Zhan, L. (2011). Overexpression of activating transcription factor 5 in human rectal cancer. Experimental and Therapeutic Medicine, 2, 827-831. https://doi.org/10.3892/etm.2011.295
MLA
Kong, X., Meng, W., Zhou, Z., Li, Y., Zhou, B., Wang, R., Zhan, L."Overexpression of activating transcription factor 5 in human rectal cancer". Experimental and Therapeutic Medicine 2.5 (2011): 827-831.
Chicago
Kong, X., Meng, W., Zhou, Z., Li, Y., Zhou, B., Wang, R., Zhan, L."Overexpression of activating transcription factor 5 in human rectal cancer". Experimental and Therapeutic Medicine 2, no. 5 (2011): 827-831. https://doi.org/10.3892/etm.2011.295
Copy and paste a formatted citation
x
Spandidos Publications style
Kong X, Meng W, Zhou Z, Li Y, Zhou B, Wang R and Zhan L: Overexpression of activating transcription factor 5 in human rectal cancer. Exp Ther Med 2: 827-831, 2011.
APA
Kong, X., Meng, W., Zhou, Z., Li, Y., Zhou, B., Wang, R., & Zhan, L. (2011). Overexpression of activating transcription factor 5 in human rectal cancer. Experimental and Therapeutic Medicine, 2, 827-831. https://doi.org/10.3892/etm.2011.295
MLA
Kong, X., Meng, W., Zhou, Z., Li, Y., Zhou, B., Wang, R., Zhan, L."Overexpression of activating transcription factor 5 in human rectal cancer". Experimental and Therapeutic Medicine 2.5 (2011): 827-831.
Chicago
Kong, X., Meng, W., Zhou, Z., Li, Y., Zhou, B., Wang, R., Zhan, L."Overexpression of activating transcription factor 5 in human rectal cancer". Experimental and Therapeutic Medicine 2, no. 5 (2011): 827-831. https://doi.org/10.3892/etm.2011.295
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