Combination of endoscopic submucosal dissection and chemoradiation therapy for superficial esophageal squamous cell carcinoma with submucosal invasion

Mochizuki,Yosuke; Saito,Yasuharu; Tsujikawa,Tomoyuki; Fujiyama,Yoshihide; Andoh,Akira

doi:10.3892/etm.2011.319

November-December 2011 Volume 2 Issue 6

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November-December 2011 Volume 2 Issue 6

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Combination of endoscopic submucosal dissection and chemoradiation therapy for superficial esophageal squamous cell carcinoma with submucosal invasion

Authors:
- Yosuke Mochizuki
- Yasuharu Saito
- Tomoyuki Tsujikawa
- Yoshihide Fujiyama
- Akira Andoh
View Affiliations / Copyright

Affiliations: Division of Digestive Endoscopy, Shiga University of Medical Science, Seta-Tukinowa, Otsu 520-2192, Japan, Department of Medicine, Shiga University of Medical Science, Seta-Tukinowa, Otsu 520-2192, Japan, Division of Mucosal Immunology, Shiga University of Medical Science, Seta-Tukinowa, Otsu 520-2192, Japan
Pages: 1065-1068
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Published online on: July 14, 2011

https://doi.org/10.3892/etm.2011.319
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Abstract

The efficacy, safety and clinical outcomes of a combination of endoscopic submucosal dissection (ESD) with subsequent chemoradiation therapy (CRT) for superficial esophageal squamous cell carcinomas (superficial ESCC) remain unclear. We assessed the outcome of the combination of ESD plus CRT for superficial ESCC. Fourteen patients with superficial ESCC invading into the muscularis mucosa or submucosa were treated with ESD plus CRT from 2004 to 2010. En bloc resection of the lesion was successfully performed in all patients. The mean diameter of the lesions was 25 mm (range 10-55). The distribution of the depth of tumor invasion was to the muscularis mucosa in 8 patients, to the upper submucosal third (sm1) in 4 patients and to the middle submucosal third (sm2) in 2 patients. The laterally resected margins and vascular invasion were cancer-negative in all patients, but lymph node involvement was detected in 2 patients. The mean follow-up period after CRT was 45 months (range 19-70). No patients died of esophageal cancer. Recurrence or metastasis of the esophageal cancer was not observed in any of the patients. The combination of ESD plus CRT is effective for superficial ESCC.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Combination of endoscopic submucosal dissection and chemoradiation therapy for superficial esophageal squamous cell carcinoma with submucosal invasion

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