Prognostic significance of microRNA gene polymorphisms in patients with surgically resected colorectal cancer

  • Authors:
    • Moon Ju Jang
    • Jong Woo Kim
    • Kyung Tae Min
    • Young Joo Jeon
    • Doyeun Oh
    • Nam Keun Kim
  • View Affiliations

  • Published online on: July 21, 2011     https://doi.org/10.3892/etm.2011.321
  • Pages: 1127-1132
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Abstract

MicroRNAs (miRNAs) are small 19- to 22-nucleotide sequences of RNA that participate in the regulation of cell differentiation, cell cycle progression and apoptosis. Although single-nucleotide polymorphisms (SNPs) in miRNA regions are considered unlikely to be functionally important, nucleotide variations within the sequences of primary (pri)- or precursor (pre)-miRNAs may affect miRNA processing and ultimately result in the modification of miRNA expression. The aim of this study was to investigate associations between four SNPs in pre-miRNA genes and the survival of colorectal cancer patients. A total of 407 colorectal patients were consecutively enrolled. DNA was extracted from blood specimens, and the hsa-mir-146aC>G, hsa-mir-149C>T, hsa-mir-196a2C>T and hsa-mir-499A>G polymorphisms were genotyped by PCR-RFLP. We were unable to identify independent prognostic SNPs for colorectal cancer. However, the heterozygous TC genotype of the 196a2C>T polymorphism was a significant risk factor for the overall survival of rectal cancer patients (HR=3.554, 95% CI 1.296‑9.747, p=0.014). Further large-population studies are warranted to define the 196a2C>T polymorphism as a prognostic factor of rectal cancer.
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November-December 2011
Volume 2 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Jang M, Kim J, Min K, Jeon Y, Oh D and Kim N: Prognostic significance of microRNA gene polymorphisms in patients with surgically resected colorectal cancer. Exp Ther Med 2: 1127-1132, 2011
APA
Jang, M., Kim, J., Min, K., Jeon, Y., Oh, D., & Kim, N. (2011). Prognostic significance of microRNA gene polymorphisms in patients with surgically resected colorectal cancer. Experimental and Therapeutic Medicine, 2, 1127-1132. https://doi.org/10.3892/etm.2011.321
MLA
Jang, M., Kim, J., Min, K., Jeon, Y., Oh, D., Kim, N."Prognostic significance of microRNA gene polymorphisms in patients with surgically resected colorectal cancer". Experimental and Therapeutic Medicine 2.6 (2011): 1127-1132.
Chicago
Jang, M., Kim, J., Min, K., Jeon, Y., Oh, D., Kim, N."Prognostic significance of microRNA gene polymorphisms in patients with surgically resected colorectal cancer". Experimental and Therapeutic Medicine 2, no. 6 (2011): 1127-1132. https://doi.org/10.3892/etm.2011.321