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Article

Interleukin 7 receptor gene polymorphisms and haplotypes are associated with susceptibility to IgA nephropathy in Korean children

  • Authors:
    • Won-Ho Hahn
    • Jin-Soon Suh
    • Hae-Jung Park
    • Byoung-Soo Cho
  • View Affiliations / Copyright

    Affiliations: Department of Pediatrics, East West Kidney Diseases Research Institute, School of Medicine, Kyung Hee University, Seoul 130-702, Republic of Korea, Kohwang Medical Research Institute, School of Medicine, Kyung Hee University, Seoul, Republic of Korea
  • Pages: 1121-1126
    |
    Published online on: July 21, 2011
       https://doi.org/10.3892/etm.2011.322
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Abstract

An abnormal T-cell response is involved in the pathogenesis of various renal diseases. Survival of naïve T cells is dependent on interleukin 7 (IL7) and its receptor (IL7R). Thus, we investigated the association between IL7R single nucleotide polymorphisms (SNPs) and childhood IgA nephropathy (IgAN). We analyzed the genotypic distributions of two missense SNPs of IL7R, rs1494558 (Ile66Thr) and rs1494555 (Val138Ile), among 198 pediatric IgAN patients and 288 healthy controls. Haplotype analysis and measurement of pair-wise linkage disequilibrium were performed. In addition, the genotypes of patient subgroups, determined by the presence of nephrotic range proteinuria (>40 mg/m2/h) and pathological advancement, were analyzed. The genotyping data of IgAN patients and controls showed significant differences in rs1494558 (codominant, P=0.0003; dominant, P=0.0003) and rs1494555 (codominant, P=0.0038; dominant, P=0.0099). In the haplotype analysis, AC (codominant, P=0.0066) and GT (codominant, P=0.0005; dominant, P=0.0006) were significantly associated with susceptibility to IgAN. Furthermore, in the analysis of clinical subgroups of IgAN patients, rs1494558 was associated with nephrotic range proteinuria (codominant, P=0.027; recessive, P=0.023). Our results suggest that IL7R may be associated with disease susceptibility and proteinuria in childhood IgAN.
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Copy and paste a formatted citation
Spandidos Publications style
Hahn W, Suh J, Park H and Cho B: Interleukin 7 receptor gene polymorphisms and haplotypes are associated with susceptibility to IgA nephropathy in Korean children. Exp Ther Med 2: 1121-1126, 2011.
APA
Hahn, W., Suh, J., Park, H., & Cho, B. (2011). Interleukin 7 receptor gene polymorphisms and haplotypes are associated with susceptibility to IgA nephropathy in Korean children. Experimental and Therapeutic Medicine, 2, 1121-1126. https://doi.org/10.3892/etm.2011.322
MLA
Hahn, W., Suh, J., Park, H., Cho, B."Interleukin 7 receptor gene polymorphisms and haplotypes are associated with susceptibility to IgA nephropathy in Korean children". Experimental and Therapeutic Medicine 2.6 (2011): 1121-1126.
Chicago
Hahn, W., Suh, J., Park, H., Cho, B."Interleukin 7 receptor gene polymorphisms and haplotypes are associated with susceptibility to IgA nephropathy in Korean children". Experimental and Therapeutic Medicine 2, no. 6 (2011): 1121-1126. https://doi.org/10.3892/etm.2011.322
Copy and paste a formatted citation
x
Spandidos Publications style
Hahn W, Suh J, Park H and Cho B: Interleukin 7 receptor gene polymorphisms and haplotypes are associated with susceptibility to IgA nephropathy in Korean children. Exp Ther Med 2: 1121-1126, 2011.
APA
Hahn, W., Suh, J., Park, H., & Cho, B. (2011). Interleukin 7 receptor gene polymorphisms and haplotypes are associated with susceptibility to IgA nephropathy in Korean children. Experimental and Therapeutic Medicine, 2, 1121-1126. https://doi.org/10.3892/etm.2011.322
MLA
Hahn, W., Suh, J., Park, H., Cho, B."Interleukin 7 receptor gene polymorphisms and haplotypes are associated with susceptibility to IgA nephropathy in Korean children". Experimental and Therapeutic Medicine 2.6 (2011): 1121-1126.
Chicago
Hahn, W., Suh, J., Park, H., Cho, B."Interleukin 7 receptor gene polymorphisms and haplotypes are associated with susceptibility to IgA nephropathy in Korean children". Experimental and Therapeutic Medicine 2, no. 6 (2011): 1121-1126. https://doi.org/10.3892/etm.2011.322
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