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Article

Decreased expression of LMO7 and its clinicopathological significance in human lung adenocarcinoma

  • Authors:
    • Hiroyuki Nakamura
    • Keiko Hori
    • Miki Tanaka-Okamoto
    • Masahiko Higashiyama
    • Yu Itoh
    • Masahiro Inoue
    • Setsuko Morinaka
    • Jun Miyoshi
  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry, Osaka Medical Center for Cancer and Cardiovascular Diseases, Higashinari-ku, Osaka 537-8511, Japan, Department of Molecular Biology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Higashinari-ku, Osaka 537-8511, Japan, Department of Thoracic Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Higashinari-ku, Osaka 537-8511, Japan, Department of Otorhinolaryngology, Kobe Japanpost Hospital, Kobe 651-8798, Japan
  • Pages: 1053-1057
    |
    Published online on: August 11, 2011
       https://doi.org/10.3892/etm.2011.329
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Abstract

LIM-domain only protein 7 (LMO7) has been suggested to act as a tumor suppressor for murine lung adenocarcinoma, while its splice variant p100 LMO7/#16 is associated with invasion and metastasis of rat AH130W1 cells. However, the importance of LMO7 in human lung cancer is unknown. We investigated LMO7 protein expression by immunohistochemistry in tumor tissues obtained from 57 patients with adenocarcinoma of the lung using a rabbit anti-LMO7 antibody. Signals for LMO7 were localized to the apical surface of the bronchial epithelium and to the cell membranes of pneumocytes in non-cancerous pulmonary tissues, but were noted circumferentially around the plasma membrane of cancer cells in all 57 patients with adenocarcinoma. The LMO7-positive group (24 patients, 42%) showed equivocal to strong expression of LMO7 in more than 50% cancer cells, while the remaining 33 patients (58%) showed LMO7 expression in less than 50% of their cancer cells. The latter group had significantly more advanced disease than the LMO7-positive group with regard to T factor (p=0.011), nodal involvement (p=0.026) and p-stage (p=0.010; χ2 test). Multivariate analysis using a logistic regression model showed that LMO7 expression was independently associated with the T factor (p=0.041). Kaplan-Meier analysis showed that a poor prognosis was associated with low expression of LMO7 (p=0.036; log-rank test). Our findings are consistent with earlier observations and demonstrate that LMO7 is inversely correlated with the development and prognosis of human lung adenocarcinoma.
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Copy and paste a formatted citation
Spandidos Publications style
Nakamura H, Hori K, Tanaka-Okamoto M, Higashiyama M, Itoh Y, Inoue M, Morinaka S and Miyoshi J: Decreased expression of LMO7 and its clinicopathological significance in human lung adenocarcinoma. Exp Ther Med 2: 1053-1057, 2011.
APA
Nakamura, H., Hori, K., Tanaka-Okamoto, M., Higashiyama, M., Itoh, Y., Inoue, M. ... Miyoshi, J. (2011). Decreased expression of LMO7 and its clinicopathological significance in human lung adenocarcinoma. Experimental and Therapeutic Medicine, 2, 1053-1057. https://doi.org/10.3892/etm.2011.329
MLA
Nakamura, H., Hori, K., Tanaka-Okamoto, M., Higashiyama, M., Itoh, Y., Inoue, M., Morinaka, S., Miyoshi, J."Decreased expression of LMO7 and its clinicopathological significance in human lung adenocarcinoma". Experimental and Therapeutic Medicine 2.6 (2011): 1053-1057.
Chicago
Nakamura, H., Hori, K., Tanaka-Okamoto, M., Higashiyama, M., Itoh, Y., Inoue, M., Morinaka, S., Miyoshi, J."Decreased expression of LMO7 and its clinicopathological significance in human lung adenocarcinoma". Experimental and Therapeutic Medicine 2, no. 6 (2011): 1053-1057. https://doi.org/10.3892/etm.2011.329
Copy and paste a formatted citation
x
Spandidos Publications style
Nakamura H, Hori K, Tanaka-Okamoto M, Higashiyama M, Itoh Y, Inoue M, Morinaka S and Miyoshi J: Decreased expression of LMO7 and its clinicopathological significance in human lung adenocarcinoma. Exp Ther Med 2: 1053-1057, 2011.
APA
Nakamura, H., Hori, K., Tanaka-Okamoto, M., Higashiyama, M., Itoh, Y., Inoue, M. ... Miyoshi, J. (2011). Decreased expression of LMO7 and its clinicopathological significance in human lung adenocarcinoma. Experimental and Therapeutic Medicine, 2, 1053-1057. https://doi.org/10.3892/etm.2011.329
MLA
Nakamura, H., Hori, K., Tanaka-Okamoto, M., Higashiyama, M., Itoh, Y., Inoue, M., Morinaka, S., Miyoshi, J."Decreased expression of LMO7 and its clinicopathological significance in human lung adenocarcinoma". Experimental and Therapeutic Medicine 2.6 (2011): 1053-1057.
Chicago
Nakamura, H., Hori, K., Tanaka-Okamoto, M., Higashiyama, M., Itoh, Y., Inoue, M., Morinaka, S., Miyoshi, J."Decreased expression of LMO7 and its clinicopathological significance in human lung adenocarcinoma". Experimental and Therapeutic Medicine 2, no. 6 (2011): 1053-1057. https://doi.org/10.3892/etm.2011.329
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