Papillary lesions of the breast diagnosed using core needle biopsies

Tokiniwa,Hideaki; Horiguchi,Jun; Takata,Daisuke; Kikuchi,Mami; Rokutanda,Nana; Nagaoka,Rin; Sato,Ayako; Odawara,Hiroki; Tozuka,Katsunori; Oyama,Tetsunari; Takeyoshi,Izumi

doi:10.3892/etm.2011.332

Papillary lesions of the breast diagnosed using core needle biopsies

Authors:
- Hideaki Tokiniwa
- Jun Horiguchi
- Daisuke Takata
- Mami Kikuchi
- Nana Rokutanda
- Rin Nagaoka
- Ayako Sato
- Hiroki Odawara
- Katsunori Tozuka
- Tetsunari Oyama
- Izumi Takeyoshi
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Affiliations: Department of Thoracic and Visceral Organ Surgery, Gunma University Graduate School of Medicine, Maebashi, Gunma 371-8511, Japan, Department of Diagnostic Pathology, Gunma University Graduate School of Medicine, Maebashi, Gunma 371-8511, Japan
Published online on: August 11, 2011 https://doi.org/10.3892/etm.2011.332
Pages: 1069-1072

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Abstract

Papillary lesions of the breast include a broad spectrum of lesions, from benign papillomas to papillary carcinomas. It is difficult to determine whether a lesion is benign or malignant based on the fragmented material of a core needle biopsy (CNB). This study evaluated patients with papillary lesions examined using CNB. We retrospectively reviewed 31 papillary lesions diagnosed using CNB between 2004 and 2007. The clinical findings of benign and malignant papillary lesions were compared. The average patient age was 48.9 years. Twelve patients presented with a discharge and 10 patients presented with a lump. Eight patients were asymptomatic. The initial diagnoses by CNB of the 31 lesions were 25 intraductal papillomas, 4 intracystic papillomas and 2 adenomas. After CNB, excisional biopsies were performed in 23 patients and biopsies with a Mammotome® in 2 patients. Seven patients underwent regular follow-up. Five (16%) of the 31 patients with papillary lesions were ultimately diagnosed with breast cancer. The average distance from the nipple to a tumor diagnosed as malignant was 2.46 cm, which was longer than for a tumor diagnosed as benign. Ultimately, 5 papillary lesions (16%) were diagnosed as breast cancer. To avoid overlooking a malignancy, surgical excision is advantageous for papillary lesions, particularly those located far from the nipple.

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