Pathological observations of lung inflammation after administration of IP-10 in influenza virus- and respiratory syncytial virus-infected mice

Luo,Hong; Wang,Dong; Che,Hai-Long; Zhao,Yue; Jin,Hong

doi:10.3892/etm.2011.350

January 2012 Volume 3 Issue 1

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January 2012 Volume 3 Issue 1

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Article

Pathological observations of lung inflammation after administration of IP-10 in influenza virus- and respiratory syncytial virus-infected mice

Authors:
- Hong Luo
- Dong Wang
- Hai-Long Che
- Yue Zhao
- Hong Jin
View Affiliations / Copyright

Affiliations: Department of Microbiology and Parasitology, China Medical University, Heping, Shenyang 110001, P.R. China, Maternal and Child Health Center of Langfang City, Langfang 065000, P.R. China, Department of Pathology, China Medical University, Shenyang 110001, P.R. China
Pages: 76-79
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Published online on: September 9, 2011

https://doi.org/10.3892/etm.2011.350
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Abstract

Pneumonia is a common complication of influenza virus infection and a common cause of death of patients. The aim of this study was to test the hypothesis that interferon-γ-inducible protein-10 (IP-10) is an important chemokine in the development of airway inflammation caused by certain viruses. Mice were infected with influenza virus after administration of murine IP-10 and the severity of pneumonia was compared with the group which was infected with influenza virus alone. Another mice group was infected with respiratory syncytial virus (RSV) after injection of IP-10 and also the severity of pneumonia was compared to the group which was infected with RSV alone. The mice infected with influenza virus or RSV after administration of IP-10 presented with more fulminant and necrotizing diffuse alveolar and bronchiole damage with lymphocyte infiltration. Our results indicate that IP-10 is an important chemokine and is associated with the severity of pneumonia caused by certain viruses.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Pathological observations of lung inflammation after administration of IP-10 in influenza virus- and respiratory syncytial virus-infected mice

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