Smoking and hepatocellular carcinoma mortality

Siegel,Abby  B.; Conner,Kristina; Wang,Shuang; Jacobson,Judith  S.; Hershman,Dawn  L.; Hidalgo,Rosa; Verna,Elizabeth  C.; Halazun,Karim; Brubaker,William; Zaretsky,Jonah; Moniodis,Anna; Delgado-Cruzata,Lissette; Dove,Lorna; Emond,Jean; Kato,Tomoaki; Brown,Robert  S.; Neugut,Alfred I.

doi:10.3892/etm.2011.351

January 2012 Volume 3 Issue 1

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January 2012 Volume 3 Issue 1

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Article

Smoking and hepatocellular carcinoma mortality

Authors:
- Abby B. Siegel
- Kristina Conner
- Shuang Wang
- Judith S. Jacobson
- Dawn L. Hershman
- Rosa Hidalgo
- Elizabeth C. Verna
- Karim Halazun
- William Brubaker
- Jonah Zaretsky
- Anna Moniodis
- Lissette Delgado-Cruzata
- Lorna Dove
- Jean Emond
- Tomoaki Kato
- Robert S. Brown
- Alfred I. Neugut
View Affiliations / Copyright

Affiliations: Department of Medicine, Columbia University, New York, NY 10032, USA, Department of Medicine, Columbia University, New York, NY 10032, USA, Mailman School of Public Health, Columbia University, New York, NY 10032, USA, Department of Surgery, Columbia University, New York, NY 10032, USA
Pages: 124-128
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Published online on: September 19, 2011

https://doi.org/10.3892/etm.2011.351
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Abstract

The association between cigarette smoking and mortality from hepatocellular carcinoma (HCC) is ambiguous. We analyzed the association between smoking and mortality in HCC patients seen at our center. We collected data retrospectively on patients diagnosed with HCC between 2002 and 2009. We estimated the association of smoking history with demographic, clinical and treatment factors. We then modeled these factors as predictors of mortality. Among smokers, we analyzed the effects of pack-year history and cessation times on survival. Two hundred and twenty-three out of 444 patients with HCC had a history of smoking. Smokers were more likely to be younger at diagnosis, to have α fetoprotein (AFP) values less than the median, and to have had surgery (p=0.04) compared to non-smokers. In a Cox model, younger age, lower AFP and Child's Class were all independently predictive of survival, but smoking was not. Smokers with over 20 pack-years did not have worse survival than lighter smokers, and cessation times also did not affect survival after controlling for age. We found a significant interaction between smoking and drinking. In our data, smoking was not independently associated with HCC survival in a multivariable model. Smoking was associated with favorable prognostic features which likely outweighed any independent effect of smoking.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Smoking and hepatocellular carcinoma mortality

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Abstract

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