|
1.
|
PA LapchakJA ZivinThe lipophilic
multifunctional antioxidant edaravone (Radicut) improves behavior
following embolic strokes in rabbits: a combination therapy study
with tissue plasminogen activatorExp
Neurol21595100200910.1016/j.expneurol.2008.09.004
|
|
2.
|
CX WangA ShuaibNeuroprotective effects of
free radical scavengers in strokeDrugs
Aging24537546200710.2165/00002512-200724070-0000217658905
|
|
3.
|
AR GreenA ShuaibTherapeutic strategies for
the treatment of strokeDrug Discov
Today11681693200610.1016/j.drudis.2006.06.00116846795
|
|
4.
|
HB Van der WorpLJ KappelleA AlgraPR BarJM
OrgogozoEB RingelsteinPM BathJ van GijnThe effect of tirilazad
mesylate on infarct volume of patients with acute ischemic
strokeNeurology58133135200211781420
|
|
5.
|
A ShuaibKR LeesP LydenJ GrottaA DavalosSM
DavisHC DienerT AshwoodWW WasiewskiU EmeribeNXY-059 for the
treatment of acute ischemic strokeN Engl J
Med357562571200710.1056/NEJMoa07024017687131
|
|
6.
|
HP Adams JrG del ZoppoMJ AlbertsDL BhattL
BrassA FurlanRL GrubbRT HigashidaEC JauchC KidwellPD LydenLB
MorgensternAI QureshiRH RosenwasserPA ScottEF WijdicksGuidelines
for the early management of adults with ischemic stroke: a
guideline from the American Heart Association/American Stroke
Association Stroke Council, Clinical Cardiology Council,
Cardiovascular Radiology and Intervention Council, and the
Atherosclerotic Peripheral Vascular Disease and Quality of Care
Outcomes in Research Interdisciplinary Working Groups: the American
Academy of Neurology affirms the value of this guideline as an
educational tool for neurologistsStroke38165517112007
|
|
7.
|
T WatanabeS YukiM EgawaH NishiProtective
effects of MCI-186 on cerebral ischemia: possible involvement of
free radical scavenging and antioxidant actionsJ Pharmacol Exp
Ther2681597160419948138971
|
|
8.
|
Y YonedaT UeharaH YamasakiY KitaM TabuchiE
MoriHospital-based study of the care and cost of acute ischemic
stroke in
JapanStroke34718724200310.1161/01.STR.0000056171.55342.FF12624297
|
|
9.
|
T YamamotoS YukiT WatanabeM MitsukaKI
SaitoK KogureDelayed neuronal death prevented by inhibition of
increased hydroxyl radical formation in a transient cerebral
ischemiaBrain
Res762240242199710.1016/S0006-8993(97)00490-39262182
|
|
10.
|
PA LapchakDM AraujoDevelopment of the
nitrone-based spin trap agent NXY-059 to treat acute ischemic
strokeCNS Drug
Rev9253262200310.1111/j.1527-3458.2003.tb00252.x14530797
|
|
11.
|
B HoehnMA YenariRM SapolskyGK
SteinbergGlutathione peroxidase overexpression inhibits cytochrome
C release and proapoptotic mediators to protect neurons from
experimental
strokeStroke3424892494200310.1161/01.STR.0000091268.25816.19
|
|
12.
|
Y OkataniA WakatsukiC KanedaMelatonin
increases activities of glutathione peroxidase and superoxide
dismutase in fetal rat brainJ Pineal
Res288996200010.1034/j.1600-079X.2001.280204.x10709970
|
|
13.
|
KG RajeshS SasaguriR SuzukiH
MaedaAntioxidant MCI-186 inhibits mitochondrial permeability
transition pore and upregulates Bcl-2 expressionAm J Physiol Heart
Circ
Physiol285H2171H2178200310.1152/ajpheart.00143.200312816747
|
|
14.
|
H ShimazakiK WatanabePT VeeraveeduM
HarimaRA ThandavarayanW ArozalH TachikawaM KodamaY AizawaThe
antioxidant edaravone attenuates ER-stress-mediated cardiac
apoptosis and dysfunction in rats with autoimmune myocarditisFree
Radic Res4410821090201010.3109/10715762.2010.49990420815771
|
|
15.
|
T AsaiY OhnoS MinatoguchiN FunaguchiH
YuhgetsuM SawadaG TakemuraA KomadaT FujiwaraH FujiwaraThe specific
free radical scavenger edaravone suppresses bleomycin-induced acute
pulmonary injury in rabbitsClin Exp Pharmacol
Physiol342226200710.1111/j.1440-1681.2007.04528.x17201731
|
|
16.
|
M NinomiyaM ShimadaN HaradaS ShiotaniS
HiroshigeY SoejimaT SuehiroK SugimachiBeneficial effect of MCI-186
on hepatic warm ischemia-reperfusion in the
ratTransplantation7414701472200210.1097/00007890-200211270-0002112451250
|
|
17.
|
N NakamotoS TadaK KameyamaK KitamuraS
KuritaY SaitoH SaitoH IshiiA free radical scavenger, edaravone,
attenuates steatosis and cell death via reducing inflammatory
cytokine production in rat acute liver injuryFree Radic
Res37849859200310.1080/1071576031000136586
|
|
18.
|
S TadaN NakamotoK KameyamaS TsunematsuN
KumagaiH SaitoH IshiiClinical usefulness of edaravone for acute
liver injuryJ Gastroenterol
Hepatol18851857200310.1046/j.1440-1746.2003.03064.x12795759
|
|
19.
|
T MiyasouAH KwonK TsujiZ QiuT OkumuraY
KamiyamaEdaravone prevents Fas-induced fulminant hepatic failure in
mice by regulating mitochondrial Bcl-xL and
BaxShock30212216200818180697
|
|
20.
|
S NagataniT SudoY MurakamiK UemuraE
HiyamaT SuedaEdaravone, a free radical scavenger, promotes
engraftment of intraportally transplanted islet
cellsPancreas40126130201110.1097/MPA.0b013e3181f7e43620938366
|
|
21.
|
M SatohN KashiharaS FujimotoH HorikeT
TokuraT NamikoshiT SasakiH MakinoA novel free radical scavenger,
edarabone, protects against cisplatin-induced acute renal damage in
vitro and in vivoJ Pharmacol Exp
Ther30511831190200310.1124/jpet.102.04752212649298
|
|
22.
|
N SasanoA EnomotoY HosoiY KatsumuraY
MatsumotoA MoritaK ShiraishiK MiyagawaH IgakiK NakagawaEdaravone, a
known free radical scavenger, enhances X-ray-induced apoptosis at
low concentrationsCancer
Lett2935257201010.1016/j.canlet.2009.12.02020092938
|
|
23.
|
N SasanoA EnomotoY HosoiY KatsumuraY
MatsumotoK ShiraishiK MiyagawaH IgakiK NakagawaFree radical
scavenger edaravone suppresses X-ray-induced apoptosis through p53
inhibition in MOLT-4 cellsJ Radiat
Res48495503200710.1269/jrr.0706117965547
|
|
24.
|
U MinhazM TanakaH TsukamotoK WatanabeS
KoideA ShohtsuH NakazawaEffect of MCI-186 on postischemic
reperfusion injury in isolated rat heartFree Radic
Res24361367199610.3109/107157696090880348733940
|
|
25.
|
TW WuLH ZengJ WuKP FungMyocardial
protection of MCI-186 in rabbit ischemia-reperfusionLife
Sci7122492255200210.1016/S0024-3205(02)01965-312215372
|
|
26.
|
M NinomiyaM ShimadaN HaradaY SoejimaT
SuehiroY MaeharaThe hydroxyl radical scavenger MCI-186 protects the
liver from experimental cold ischaemia-reperfusion injuryBr J
Surg91184190200410.1002/bjs.440114760666
|
|
27.
|
F SuzukiY HashikuraH IseA IshidaJ
NakayamaM TakahashiS MiyagawaU IkedaMCI-186 (edaravone), a free
radical scavenger, attenuates hepatic warm ischemia-reperfusion
injury in ratsTranspl
Int18844853200510.1111/j.1432-2277.2005.00094.x15948865
|
|
28.
|
T YangYF MaoSQ LiuJ HouZY CaiJY HuX NiXM
DengXY ZhuProtective effects of the free radical scavenger
edaravone on acute pancreatitis-associated lung injuryEur J
Pharmacol630152157201010.1016/j.ejphar.2009.12.02520035747
|
|
29.
|
K SueishiK MishimaK MakinoY ItohK TsuruyaH
HirakataR OishiProtection by a radical scavenger edaravone against
cisplatin-induced nephrotoxicity in ratsEur J
Pharmacol451203208200210.1016/S0014-2999(02)02251-312231392
|
|
30.
|
K DoiY SuzukiA NakaoT FujitaE NoiriRadical
scavenger edaravone developed for clinical use ameliorates
ischemia/reperfusion injury in rat kidneyKidney
Int6517141723200410.1111/j.1523-1755.2004.00567.x15086910
|
|
31.
|
M TamamuraM SaitoY KinoshitaS ShimizuI
SatohK ShomoriF DimitriadisK SatohProtective effect of edaravone, a
free-radical scavenger, on ischaemia-reperfusion injury in the rat
testisBJU
Int105870876201010.1111/j.1464-410X.2009.08798.x19694712
|
|
32.
|
K TsujitaH ShimomuraH KawanoJ HokamakiM
FukudaT YamashitaS HidaY NakamuraY NagayoshiT SakamotoM YoshimuraH
AraiH OgawaEffects of edaravone on reperfusion injury in patients
with acute myocardial infarctionAm J
Cardiol94481484200410.1016/j.amjcard.2004.05.00715325934
|
|
33.
|
K TsujitaH ShimomuraK KaikitaH KawanoJ
HokamakiY NagayoshiT YamashitaM FukudaY NakamuraT SakamotoM
YoshimuraH OgawaLong-term efficacy of edaravone in patients with
acute myocardial infarctionCirc
J70832837200610.1253/circj.70.83216799234
|
|
34.
|
R SukmawanT YadaE ToyotaY NeishiT KumeY
ShinozakiH MoriY OgasawaraF KajiyaK YoshidaEdaravone preserves
coronary microvascular endothelial function after
ischemia/reperfusion on the beating canine heart in vivoJ Pharmacol
Sci104341348200710.1254/jphs.FP0070186
|
|
35.
|
H OnogiS MinatoguchiXH ChenN BaoH
KobayashiY MisaoS YasudaT YamakiR MaruyamaY UnoM AraiG TakemuraH
FujiwaraEdaravone reduces myocardial infarct size and improves
cardiac function and remodelling in rabbitsClin Exp Pharmacol
Physiol3310351041200610.1111/j.1440-1681.2006.04483.x17042911
|
|
36.
|
H YagiS HorinakaH MatsuokaEdaravone
prevented deteriorated cardiac function after myocardial
ischemia-reperfusion via inhibiting lipid peroxidation in ratJ
Cardiovasc
Pharmacol464651200510.1097/01.fjc.0000162772.16797.7f
|
|
37.
|
K YamazakiS MiwaS ToyokuniS NemotoW
OriyanhanK TakabaY SajiA MaruiT NishinaT IkedaM KomedaEffect of
edaravone, a novel free radical scavenger, supplemented to
cardioplegia on myocardial function after cardioplegic arrest: in
vitro study of isolated rat heartHeart
Vessels24228235200910.1007/s00380-008-1106-119466525
|
|
38.
|
M NimataTA OkabeM HattoriZ YuanK ShiojiC
KishimotoMCI-186 (edaravone), a novel free radical scavenger,
protects against acute autoimmune myocarditis in ratsAm J Physiol
Heart Circ
Physiol289H2514H2518200510.1152/ajpheart.00661.200516100244
|
|
39.
|
Y KotaniK IshinoS OsakiO HonjoT SuezawaK
KankiC YutaniS SanoEfficacy of MCI-186, a free-radical scavenger
and antioxidant, for resuscitation of nonbeating donor heartsJ
Thorac Cardiovasc
Surg13316261632200710.1016/j.jtcvs.2007.01.06817532966
|
|
40.
|
M YamawakiN SasakiM ShimoyamaJ MiakeK
OginoO IgawaF TajimaC ShigemasaI HisatomeProtective effect of
edaravone against hypoxia-reoxygenation injury in rabbit
cardiomyocytesBr J
Pharmacol142618626200410.1038/sj.bjp.070577515148265
|
|
41.
|
T AkaoI TakeyoshiO TotsukaK ArakawaM
MuraokaK KobayashiK KonnoK MatsumotoY MorishitaEffect of the free
radical scavenger MCI-186 on pulmonary ischemia-reperfusion injury
in dogsJ Heart Lung
Transplant25965971200610.1016/j.healun.2006.03.00416890118
|
|
42.
|
W QiuH GuL ZhengJ ZhouD ChenY
ChenPretreatment with edaravone reduces lung mitochondrial damage
in an infant rabbit ischemia-reperfusion modelJ Pediatr
Surg4320532060200810.1016/j.jpedsurg.2008.05.01918970940
|
|
43.
|
YA ReyesT ShimoyamaH AkamatsuM
SunamoriMCI-186 (edaravone), a free radical scavenger, attenuates
ischemia-reperfusion injury and activation of phospholipase A(2) in
an isolated rat lung model after 18 h of cold preservationEur J
Cardiothorac
Surg29304311200610.1016/j.ejcts.2005.12.00516427299
|
|
44.
|
S TajimaM BandoY IshiiT HosonoH YamasawaS
OhnoT TakadaE SuzukiF GejyoY SugiyamaEffects of edaravone, a
free-radical scavenger, on bleomycin-induced lung injury in miceEur
Respir J3213371343200810.1183/09031936.0016440718614556
|
|
45.
|
N TomatsuriN YoshidaT TakagiK KatadaY
IsozakiE ImamotoK UchiyamaS KokuraH IchikawaY NaitoT OkanoueT
YoshikawaEdaravone, a newly developed radical scavenger, protects
against ischemia-reperfusion injury of the small intestine in
ratsInt J Mol Med13105109200414654979
|
|
46.
|
K ShimizuH KogaM IidaK
HarumaMicrocirculatory changes in experimental mesenteric
longitudinal ulcers of the small intestine in ratsDig Dis
Sci5230193028200710.1007/s10620-007-9804-617393313
|
|
47.
|
H KonoM AsakawaH FujiiA MakiH AmemiyaM
YamamotoM MatsudaY MatsumotoEdaravone, a novel free radical
scavenger, prevents liver injury and mortality in rats administered
endotoxinJ Pharmacol Exp
Ther3077482200310.1124/jpet.103.05359512954792
|
|
48.
|
S HiranumaK ItoY NodaH OzasaY KoikeS
HorikawaAmelioration of hepatic ischemia/reperfusion injury in the
remnant liver after partial hepatectomy in ratsJ Gastroenterol
Hepatol2221672172200710.1111/j.1440-1746.2006.04779.x18031376
|
|
49.
|
H KonoCG WoodsA MakiHD ConnorRP MasonI
RusynH FujiiElectron spin resonance and spin trapping technique
provide direct evidence that edaravone prevents acute
ischemia-reperfusion injury of the liver by limiting free
radical-mediated tissue damageFree Radic
Res40579588200610.1080/10715760600606374
|
|
50.
|
A NakamuraY AkamatsuS MiyagiT FukumoriS
SekiguchiS SatomiA free radical scavenger, edaravone, prevents
ischemia-reperfusion injury in liver grafts from non-heart-beating
donorsTransplant
Proc4021712174200810.1016/j.transproceed.2008.06.04918790183
|
|
51.
|
Y OkataniA WakatsukiH EnzanY
MiyaharaEdaravone protects against ischemia/reperfusion-induced
oxidative damage to mitochondria in rat liverEur J
Pharmacol465163170200310.1016/S0014-2999(03)01463-812650846
|
|
52.
|
M TaniguchiM UchinamiK DoiM YoshidaH
SasakiK TamagawaT HoriuchiK TanakaEdaravone reduces
ischemia-reperfusion injury mediators in rat liverJ Surg
Res1376974200710.1016/j.jss.2006.06.03317064733
|
|
53.
|
K TsujiAH KwonH YoshidaZ QiuM KaiboriT
OkumuraY KamiyamaFree radical scavenger (edaravone) prevents
endotoxin-induced liver injury after partial hepatectomy in ratsJ
Hepatol4294101200510.1016/j.jhep.2004.09.018
|
|
54.
|
H YoshidaAH KwonK HabaraM YamadaM KaiboriY
KamiyamaM NishizawaS ItoT OkumuraEdaravone inhibits the induction
of iNOS gene expression at transcriptional and posttranscriptional
steps in murine
macrophagesShock30734739200810.1097/SHK.0b013e318173ea0b18496239
|
|
55.
|
Y ArakiA AndohT YokonoN AsanoK YoshikawaS
BambaI IshizukaY FujiyamaThe free radical scavenger edaravone
suppresses experimental closed duodenal loop-induced acute
pancreatitis in ratsInt J Mol Med12121124200312792821
|
|
56.
|
M TaharaM NakayamaMB JinM FujitaT SuzukiM
TaniguchiT ShimamuraH FurukawaS TodoA radical scavenger, edaravone,
protects canine kidneys from ischemia-reperfusion injury after 72
hours of cold preservation and
autotransplantationTransplantation80213221200510.1097/01.TP.0000165092.07375.C9
|
|
57.
|
T SomeyaK KanekoT YamadaY YamashiroEffect
of a novel free radical scavenger, edaravone, on puromycin
aminonucleoside induced nephrosis in ratsPediatr
Nephrol2014301434200510.1007/s00467-005-1959-916079985
|
|
58.
|
H MatsumuraA AshidaK HiranoH NakakuraH
TamaiProtective effect of radical scavenger edaravone against
puromycin nephrosisClin
Nephrol66405410200610.5414/CNP6640517176911
|
|
59.
|
S MatsumotoT HanaiN YoshiokaN ShimizuT
SugiyamaH UemuraRM LevinEdaravone protects against
ischemia/reperfusion-induced functional and biochemical changes in
rat urinary
bladderUrology66892896200510.1016/j.urology.2005.04.03516230177
|
|
60.
|
S ShimizuM SaitoY KinoshitaE KazuyamaM
TamamuraI SatohK SatohAcute urinary retention and subsequent
catheterization cause lipid peroxidation and oxidative DNA damage
in the bladder: preventive effect of edaravone, a free-radical
scavengerBJU Int104713717200910.1111/j.1464-410X.2009.08471.x
|
|
61.
|
S KatoMH HusseinH KakitaT GotoGA DaoudT
KatoT SugiuraM NobataY NakajimaT EndoK MizunoT ItoI KatoS SuzukiH
TogariEdaravone, a novel free radical scavenger, reduces
high-mobility group box 1 and prolongs survival in a neonatal
sepsis
modelShock32586592200910.1097/SHK.0b013e3181a2b88619295481
|
|
62.
|
T KoizumiH TanakaS SakakiS ShimazakiThe
therapeutic efficacy of edaravone in extensively burned ratsArch
Surg141992995200610.1001/archsurg.141.10.99217043277
|
|
63.
|
T MoriH YamamotoT TabataT ShimizuY EndoK
HanasawaM FujimiyaT TaniA free radical scavenger, edaravone
(MCI-186), diminishes intestinal neutrophil lipid peroxidation and
bacterial translocation in a rat hemorrhagic shock modelCrit Care
Med3310641069200510.1097/01.CCM.0000162952.14590.EC
|
|
64.
|
Y UjiH YamamotoT MoriH AkaboriH
TsuchihashiT ShimizuY EndoT TaniEdaravone improves the survival of
rats subjected to hemorrhagic shock without resuscitationSurg
Today38476477200810.1007/s00595-007-3666-618560976
|
|
65.
|
T KawasakiK IshiharaY AgoS NakamuraS ItohA
BabaT MatsudaProtective effect of the radical scavenger edaravone
against methamphetamine-induced dopaminergic neurotoxicity in mouse
striatumEur J Pharmacol5429299200610.1016/j.ejphar.2006.05.012
|
|
66.
|
Y NakamuraY YamadaH ShimomuraY NagayoshiK
TsujitaT YamashitaM FukudaK OhbaH NakoY OguraT ChitoseM YamaguchiT
NagataH SoejimaK KaikitaS SugiyamaH OgawaThe effect of edaravone on
plasma monocyte chemoattractant protein-1 levels in patients with
acute myocardial infarctionJ
Cardiol54416424200910.1016/j.jjcc.2009.07.00119944317
|
|
67.
|
S OnimaruK NakamuraH KariyazonoR IkedaT
UenoY FukumotoA YabukiR SakataK YamadaInhibitory effects of
edaravone on the production of tumor necrosis factor-alpha in the
isolated heart undergoing ischemia and reperfusionHeart
Vessels21108115200610.1007/s00380-005-0863-316550312
|
|
68.
|
TA OkabeC KishimotoM HattoriM NimataK
ShiojiT KitaCardioprotective effects of
3-methyl-1-phenyl-2-pyrazolin-5-one (MCI-186), a novel free radical
scavenger, on acute autoimmune myocarditis in ratsExp Clin
Cardiol9177180200419641722
|
|
69.
|
S TajimaM SodaM BandoM EnomotoH YamasawaS
OhnoT TakadaE SuzukiF GejyoY SugiyamaPreventive effects of
edaravone, a free radical scavenger, on lipopolysaccharide-induced
lung injury in
miceRespirology13646653200810.1111/j.1440-1843.2008.01322.x18713088
|
|
70.
|
K KanekoY YonemitsuT FujiiM OnimaruCH JinM
InoueM HasegawaT OnoharaY MaeharaK SueishiA free radical scavenger
but not FGF-2-mediated angiogenic therapy rescues myonephropathic
metabolic syndrome in severe hindlimb ischemiaAm J Physiol Heart
Circ Physiol290H1484H1492200610.1152/ajpheart.01006.2005
|
