Beyond free radical scavenging: Beneficial effects of edaravone (Radicut) in various diseases (Review)

Kikuchi,Kiyoshi; Takeshige,Nobuyuki; Miura,Naoki; Morimoto,Yoko; Ito,Takashi; Tancharoen,Salunya; Miyata,Kei; Kikuchi,Chiemi; Iida,Narumi; Uchikado,Hisaaki; Miyagi,Naohisa; Shiomi,Naoto; Kuramoto,Terukazu; Maruyama,Ikuro; Morioka,Motohiro; Kawahara,Ko-Ichi

doi:10.3892/etm.2011.352

Beyond free radical scavenging: Beneficial effects of edaravone (Radicut) in various diseases (Review)

Authors:
- Kiyoshi Kikuchi
- Nobuyuki Takeshige
- Naoki Miura
- Yoko Morimoto
- Takashi Ito
- Salunya Tancharoen
- Kei Miyata
- Chiemi Kikuchi
- Narumi Iida
- Hisaaki Uchikado
- Naohisa Miyagi
- Naoto Shiomi
- Terukazu Kuramoto
- Ikuro Maruyama
- Motohiro Morioka
- Ko-Ichi Kawahara
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Affiliations: Department of Neurosurgery, Yame Public General Hospital, Yame 834-0034, Japan, Department of Neurosurgery, Kurume University School of Medicine, Kurume 830-0011, Japan, Veterinary Teaching Hospital and Laboratory of Veterinary Diagnostic Imaging, Faculty of Agriculture, Kagoshima University, Kagoshima 890-0065, Japan, Department of Restorative Dentistry and Endodontology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8544, Japan, Systems Biology Thrombogenesis Regulation, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8520, Japan, Department of Pharmacology, Faculty of Dentistry, Mahidol University, Rajthevee, Bangkok 10400, Thailand, Department of Rehabilitation, Nishida Koutoku Hospital, Oita 876-0047, Japan, Research Laboratory, Kohjin Co., Ltd., Oita 876-8580, Japan, Department of Emergency, Saiseikai Shiga Hospital, Shiga 520-3046, Japan, Department of Neurosurgery, Omuta City General Hospital, Fukuoka 836-8567, Japan
Published online on: September 20, 2011 https://doi.org/10.3892/etm.2011.352
Pages: 3-8

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Abstract

Free radicals play an important role in the pathogenesis of a variety of diseases; thus, they are an attractive target for therapeutic intervention in these diseases. Compounds capable of scavenging free radicals have been developed for this purpose and some, developed for the treatment of cerebral ischemic stroke, have progressed to clinical trials. One such scavenger, edaravone, is used to treat patients within 24 h of stroke. Edaravone, which can diffuse into many disease‑affected organs, also shows protective effects in the heart, lung, intestine, liver, pancreas, kidney, bladder and testis. As well as scavenging free radicals, edaravone has anti-apoptotic, anti-necrotic and anti-cytokine effects in various diseases. Here, we critically review the literature on its clinical efficacy and examine whether edaravone should be considered a candidate for worldwide development, focusing on its effects on diseases other than cerebral infarction. Edaravone has been safely used as a free radical scavenger for more than 10 years; we propose that edaravone may offer a novel treatment option for several diseases.

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