TEM observation of ultrasound-induced mitophagy in nasopharyngeal carcinoma cells in the presence of curcumin

Wang,Xinna; Leung,Albert   Wingnang; Luo,Jianmei; Xu,Chuanshan

doi:10.3892/etm.2011.365

TEM observation of ultrasound-induced mitophagy in nasopharyngeal carcinoma cells in the presence of curcumin

Authors:
- Xinna Wang
- Albert Wingnang Leung
- Jianmei Luo
- Chuanshan Xu
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Affiliations: Department of Ultrasound, The Affiliated Hospital, Xi'an Medical University, Xi'an, P.R. China, School of Chinese Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, P.R. China
Published online on: October 13, 2011 https://doi.org/10.3892/etm.2011.365
Pages: 146-148

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Abstract

The present study was designed to observe the initiation of mitophagy in tumor cells after ultrasound treatment in the presence of curcumin under transmission electron microscopy. Nasopharyngeal carcinoma CNE2 cells were incubated with 10 µM curcumin and then exposed to ultrasound for 8 sec at an intensity of 0.46 W/cm2. Severely swollen mitochondria, disrupted mitochondria and mitophagy were noted in the CNE2 cells after ultrasound treatment in the presence of curcumin. Our findings demonstrated that ultrasound treatment in the presence of curcumin significantly initiated mitophagy in CNE2 cells, which suggests that mitophagy serves as an important event in the process of cell death of nasopharyngeal carcinoma cells.

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