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Article

Quality of life in advanced non-small cell lung cancer patients receiving palliative chemotherapy: A meta-analysis of randomized controlled trials

  • Authors:
    • Ayako Matsuda
    • Kazue Yamaoka
    • Toshiro Tango
  • View Affiliations / Copyright

    Affiliations: Surveillance Division Population-Based Cancer Registry Section, Center for Cancer Control and Information Services, National Cancer Center, Tokyo 104-0045, Japan, Teikyo University, Graduate School of Public Health, Tokyo, Japan, Center for Medical Statistics, Tokyo, Japan
  • Pages: 134-140
    |
    Published online on: October 18, 2011
       https://doi.org/10.3892/etm.2011.368
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Abstract

For advanced non-small cell lung cancer (NSCLC) patients, the only treatment option is palliative therapy, with the aim of prolonging overall survival and improving disease‑related symptoms and quality of life (QOL). However, to date, the effect of palliative care on QOL has not yet been thoroughly examined, and there has been no meta-analysis of previous studies reporting QOL outcomes following palliative care. We consider that it is important to evaluate not only survival and/or response rates, but also QOL in patients with advanced NSCLC receiving palliative chemotherapy. The aim of the present study was to obtain useful information for the selection of suitable chemotherapy regimens for advanced NSCLC patients, taking into consideration QOL, and to demonstrate the importance of QOL assessments during treatment. We performed a meta-analysis of QOL outcomes following treatments that compared carboplatin- to cisplatin-based chemotherapy. Trials were eligible for analysis if they had compared carboplatin- to cisplatin-based chemotherapy in advanced NSCLC patients who had not received prior chemotherapy, and if these studies reported QOL data. In the six trials eligible for analysis, 2,405 patients were randomized to receive cisplatin-based or carboplatin-based chemotherapy. The patients who received carboplatin-based chemotherapy had higher global QOL and less severe symptoms than those who received cisplatin-based chemotherapy. The survival rate, which was the primary outcome in clinical trials, and the response rate did not differ significantly between the two treatment groups. It is important to evaluate QOL in addition to the survival and response rates for advanced NSCLC, particularly when the treatment is palliative.
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Copy and paste a formatted citation
Spandidos Publications style
Matsuda A, Yamaoka K and Tango T: Quality of life in advanced non-small cell lung cancer patients receiving palliative chemotherapy: A meta-analysis of randomized controlled trials. Exp Ther Med 3: 134-140, 2012.
APA
Matsuda, A., Yamaoka, K., & Tango, T. (2012). Quality of life in advanced non-small cell lung cancer patients receiving palliative chemotherapy: A meta-analysis of randomized controlled trials. Experimental and Therapeutic Medicine, 3, 134-140. https://doi.org/10.3892/etm.2011.368
MLA
Matsuda, A., Yamaoka, K., Tango, T."Quality of life in advanced non-small cell lung cancer patients receiving palliative chemotherapy: A meta-analysis of randomized controlled trials". Experimental and Therapeutic Medicine 3.1 (2012): 134-140.
Chicago
Matsuda, A., Yamaoka, K., Tango, T."Quality of life in advanced non-small cell lung cancer patients receiving palliative chemotherapy: A meta-analysis of randomized controlled trials". Experimental and Therapeutic Medicine 3, no. 1 (2012): 134-140. https://doi.org/10.3892/etm.2011.368
Copy and paste a formatted citation
x
Spandidos Publications style
Matsuda A, Yamaoka K and Tango T: Quality of life in advanced non-small cell lung cancer patients receiving palliative chemotherapy: A meta-analysis of randomized controlled trials. Exp Ther Med 3: 134-140, 2012.
APA
Matsuda, A., Yamaoka, K., & Tango, T. (2012). Quality of life in advanced non-small cell lung cancer patients receiving palliative chemotherapy: A meta-analysis of randomized controlled trials. Experimental and Therapeutic Medicine, 3, 134-140. https://doi.org/10.3892/etm.2011.368
MLA
Matsuda, A., Yamaoka, K., Tango, T."Quality of life in advanced non-small cell lung cancer patients receiving palliative chemotherapy: A meta-analysis of randomized controlled trials". Experimental and Therapeutic Medicine 3.1 (2012): 134-140.
Chicago
Matsuda, A., Yamaoka, K., Tango, T."Quality of life in advanced non-small cell lung cancer patients receiving palliative chemotherapy: A meta-analysis of randomized controlled trials". Experimental and Therapeutic Medicine 3, no. 1 (2012): 134-140. https://doi.org/10.3892/etm.2011.368
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