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Article

Predictive value of p53 expression in the risk of malignant gastrointestinal stromal tumors: Evidence from 19 studies

  • Authors:
    • Liang Zong
    • Ping Chen
    • Jian Jiang
    • Lei Wang
    • Qing Guo Li
  • View Affiliations / Copyright

    Affiliations: Department of Gastrointestinal Surgery, Su Bei People's Hospital, Yangzhou University, Yangzhou, Jiangsu, P.R. China
  • Pages: 87-92
    |
    Published online on: October 19, 2011
       https://doi.org/10.3892/etm.2011.369
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Abstract

The current published data on p53 expression and its predictive value in the risk of malignant gastrointestinal stromal tumors (GIST) has are inconclusive. To derive a more precise estimation of the correlation between p53 and the biological behavior of GIST, a meta-analysis was performed. Studies were identified by searching PubMed and Embase. Inclusion criteria were GIST patients, and the evaluation of p53 expression and risk of malignancy. The odds ratio (OR) for a positive rate of p53 in the benign group vs. that in the malignant group and the ORs for the positive rate of p53 in the National Institutes of Health (NIH) very low risk + low risk group (VL+L) vs. the NIH intermediate risk + high risk (I+H) group were calculated with a 95% confidence interval (CI) for each study as an estimation of the predictive value of p53. A total of 19 studies including 1163 patients were involved in this meta-analysis. The overall OR for the positive rate of p53 in the malignant group vs. the benign group revealed that significantly elevated risks of positive p53 in the malignant group were achieved (OR 0.14, 95% CI: 0.06-0.31, P<0.00001, Pheterogeneity=0.86). Moreover, significantly elevated risks of correlation between p53 expression and the NIH I+H group were achieved in the comparison of the NIH VL+L group vs. the NIH I+H group (OR, 0.25; 95% CI, 0.17‑0.38; P<0.00001, Pheterogeneity=0.04). The results indicate that p53 expression correlates with poor prognosis in GIST and has a close relationship within the NIH I+H group.
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Copy and paste a formatted citation
Spandidos Publications style
Zong L, Chen P, Jiang J, Wang L and Li Q: Predictive value of p53 expression in the risk of malignant gastrointestinal stromal tumors: Evidence from 19 studies. Exp Ther Med 3: 87-92, 2012.
APA
Zong, L., Chen, P., Jiang, J., Wang, L., & Li, Q. (2012). Predictive value of p53 expression in the risk of malignant gastrointestinal stromal tumors: Evidence from 19 studies. Experimental and Therapeutic Medicine, 3, 87-92. https://doi.org/10.3892/etm.2011.369
MLA
Zong, L., Chen, P., Jiang, J., Wang, L., Li, Q."Predictive value of p53 expression in the risk of malignant gastrointestinal stromal tumors: Evidence from 19 studies". Experimental and Therapeutic Medicine 3.1 (2012): 87-92.
Chicago
Zong, L., Chen, P., Jiang, J., Wang, L., Li, Q."Predictive value of p53 expression in the risk of malignant gastrointestinal stromal tumors: Evidence from 19 studies". Experimental and Therapeutic Medicine 3, no. 1 (2012): 87-92. https://doi.org/10.3892/etm.2011.369
Copy and paste a formatted citation
x
Spandidos Publications style
Zong L, Chen P, Jiang J, Wang L and Li Q: Predictive value of p53 expression in the risk of malignant gastrointestinal stromal tumors: Evidence from 19 studies. Exp Ther Med 3: 87-92, 2012.
APA
Zong, L., Chen, P., Jiang, J., Wang, L., & Li, Q. (2012). Predictive value of p53 expression in the risk of malignant gastrointestinal stromal tumors: Evidence from 19 studies. Experimental and Therapeutic Medicine, 3, 87-92. https://doi.org/10.3892/etm.2011.369
MLA
Zong, L., Chen, P., Jiang, J., Wang, L., Li, Q."Predictive value of p53 expression in the risk of malignant gastrointestinal stromal tumors: Evidence from 19 studies". Experimental and Therapeutic Medicine 3.1 (2012): 87-92.
Chicago
Zong, L., Chen, P., Jiang, J., Wang, L., Li, Q."Predictive value of p53 expression in the risk of malignant gastrointestinal stromal tumors: Evidence from 19 studies". Experimental and Therapeutic Medicine 3, no. 1 (2012): 87-92. https://doi.org/10.3892/etm.2011.369
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