Serum albumin is present at higher levels in alcoholic liver cirrhosis as compared to HCV-related cirrhosis

Kotoh,Kazuhiro; Fukushima,Marie; Horikawa,Yuki; Yamashita,Shinsaku; Kohjima,Motoyuki; Nakamuta,Makoto; Enjoji,Munechika

doi:10.3892/etm.2011.370

January 2012 Volume 3 Issue 1

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

January 2012 Volume 3 Issue 1

Full Size Image

Article

Serum albumin is present at higher levels in alcoholic liver cirrhosis as compared to HCV-related cirrhosis

Authors:
- Kazuhiro Kotoh
- Marie Fukushima
- Yuki Horikawa
- Shinsaku Yamashita
- Motoyuki Kohjima
- Makoto Nakamuta
- Munechika Enjoji
View Affiliations / Copyright

Affiliations: Department of Hepatology and Pancreatology, Kyushu University Hospital, Fukuoka, Japan, Department of Gastroenterology, National Hospital Organization, Kyushu Medical Center, Fukuoka, Japan, Health Care Center, Fukuoka University, Jonan-ku, Fukuoka 814-0180, Japan
Pages: 72-75
|
Published online on: October 19, 2011

https://doi.org/10.3892/etm.2011.370
Expand metrics +

Abstract

Residual hepatic functional reserve in cirrhotic patients is generally evaluated by a multivariate scoring system (Child-Pugh classification), which includes serum albumin levels as a variable. However, several patients show discrepancies between serum albumin levels and the progression of liver fibrosis, especially those with alcoholic cirrhosis. To assess whether hepatic capacity of protein synthesis varies with the etiology of cirrhosis, serum albumin and cholinesterase levels, and prothrombin time were compared between alcoholic cirrhosis and hepatitis C virus (HCV)-related cirrhosis. To minimize the influence of malnutrition and extrahepatic platelet destruction, patients with hepatocellular carcinoma, uncontrolled diabetes, appetite loss and/or splenal longitudinal size >15 cm were excluded. The patients with compensated liver cirrhosis were divided into three groups as follows: alcohol+/HCV+ (alcohol + HCV group; n=31), alcohol-/HCV+ (HCV group; n=31) and alcohol+/HCV- (alcohol group; n=27). These groups were adjusted with respect to age, gender, body mass index and platelet count. Serum albumin levels in the alcohol group were significantly higher than those in the HCV group, with a difference of approximately 0.5 g/dl in every class of platelet count. The correlation of the alcohol + HCV group was intermediate between the alcohol and HCV groups. On the other hand, the correlations between serum cholinesterase levels and platelet counts were similar among the three groups. The prothrombin time was also comparable among the groups. Accordingly, serum albumin levels were higher in patients with alcoholic cirrhosis and alcohol consumption should be carefully considered when evaluating hepatic functional reserve.

View Figures

View References

1.	A Di SarioG FeliciangeliE BendiaA BenedettiDiagnosis of liver fibrosisEur Rev Med Pharmacol Sci811182004
2.	EJ MullinMS MetcalfeGJ MaddernHow much liver resection is too much?Am J Surg1908797200510.1016/j.amjsurg.2005.01.04315972178
3.	J FazakasT MandliG TherEvaluation of liver function for hepatic resectionTransplant Proc38798800200610.1016/j.transproceed.2006.01.04816647474
4.	PD SchneiderPreoperative assessment of liver functionSurg Clin North Am84355373200410.1016/S0039-6109(03)00224-X
5.	DK ParkSH UmJW LeeClinical significance of variceal hemorrhage in recent years in patients with liver cirrhosis and esophageal varicesJ Gastroenterol Hepatol1910421051200415304123
6.	X FornsS AmpurdanèsJM LlovetIdentification of chronic hepatitis C patients without hepatic fibrosis by a simple predictive modelHepatology36986992200210.1053/jhep.2002.3612812297848
7.	CT WaiJK GreensonRJ FontanaJD KalbfieischJA MarreroHS ConjeevaramAS LokA simple noninvasive index can predict both significant fibrosis and cirrhosis in patients with chronic hepatitis CHepatology38518516200310.1053/jhep.2003.5034612883497
8.	F MangusoG D’AmbraA MenchiseR SollazzoL D’AgostinoEffects of an appropriate oral diet on the nutritional status of patients with HCV-related liver cirrhosis: a prospective studyClin Nutr24751759200510.1016/j.clnu.2005.02.01016182039
9.	H WadenvikI DenforsJ KuttiSplenic blood flow and intrasplenic platelet kinetics in relation to spleen volumeBr J Haematol6718118519873676106
10.	K IzunoS FujiyamaJ ShibataK YoshidaT SatoO ShimomuraM TakahashiTransrectal portal scintigraphy with I123 iodoamphetamine in liver diseasesHepatogastroenterology38S8S111991
11.	C TatsumiM KudoK UeshimaNoninvasive evaluation of hepatic fibrosis using serum fibrotic markers, transient elastography (FibroScan) and real-time tissue elastographyIntervirology512733200810.1159/000122602
12.	J PoniachikDE BernsteinKR ReddyLJ JeffersME Coelho-LittleF CivantosER SchiffThe role of laparoscopy in the diagnosis of cirrhosisGastrointest Endosc43568571199610.1016/S0016-5107(96)70192-X8781934
13.	A RegevM BerhoLJ JeffersSampling error and intra-observer variation in liver biopsy in patients with chronic HCV infectionAm J Gastroenterol9726142618200210.1111/j.1572-0241.2002.06038.x12385448
14.	RJ FontanaZG GoodmanJL DienstagRelationship of serum fibrosis markers with liver fibrosis stage and collagen content in patients with advanced chronic hepatitis CHepatology47789798200810.1002/hep.2209918175357
15.	G AnnoniFR WeinerM ColomboMJ CzajaMA ZernAlbumin and collagen gene regulation in alcohol- and virus-induced human liver diseaseGastroenterology9819720219902293578

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Serum albumin is present at higher levels in alcoholic liver cirrhosis as compared to HCV-related cirrhosis

This article is mentioned in:

Abstract

Figure 1

Figure 2

Related Articles