Objective evaluation of the alleviating effects of Goshajinkigan on peripheral neuropathy induced by paclitaxel/carboplatin therapy: A multicenter collaborative Study

Kaku,Hiroi; Kumagai,Seisuke; Onoue,Hiroki; Takada,Anna; Shoji,Tadahiro; Miura,Fumiharu; Yoshizaki,Akira; Sato,Shinya; Kigawa,Junzo; Arai,Tsutomu; Tsunoda,Shinpei; Tominaga,Eiichiro; Aoki,Daisuke; Sugiyama,Toru

doi:10.3892/etm.2011.375

January 2012 Volume 3 Issue 1

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January 2012 Volume 3 Issue 1

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Article Open Access

Objective evaluation of the alleviating effects of Goshajinkigan on peripheral neuropathy induced by paclitaxel/carboplatin therapy: A multicenter collaborative Study

Authors:
- Hiroi Kaku
- Seisuke Kumagai
- Hiroki Onoue
- Anna Takada
- Tadahiro Shoji
- Fumiharu Miura
- Akira Yoshizaki
- Shinya Sato
- Junzo Kigawa
- Tsutomu Arai
- Shinpei Tsunoda
- Eiichiro Tominaga
- Daisuke Aoki
- Toru Sugiyama
View Affiliations / Copyright

Affiliations: Department of Obstetrics and Gynecology, Iwate Medical University, Morioka, Iwate 020-8505, Japan, Department of Obstetrics and Gynecology, Tottori University Hospital, Tottori 683-8504, Japan, Cancer Center, Tottori University Hospital, Tottori 683-8504, Japan, Department of Obstetrics and Gynecology, Kitasato University Hospital, Kanagawa 252-0375, Japan, Department of Obstetrics and Gynecology, Keio University Hospital, Tokyo 160-8582, Japan
Pages: 60-65
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Published online on: October 24, 2011

https://doi.org/10.3892/etm.2011.375
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Abstract

Paclitaxel/carboplatin chemotherapy for cancer (TC therapy) exhibits neurotoxicity and causes peripheral neuropathy at a high frequency, which is difficult to cope with. In this study, we investigated the efficacy of Goshajinkigan, a traditional Japanese herbal medicine, for TC therapy-induced peripheral neuropathy. The subjects included in our study were patients with ovarian or endometrial cancer who underwent TC therapy and developed peripheral neuropathy. The patients were randomly divided into Group A, comprising of 14 patients (vitamin B12 treatment), and Group B, comprising of 15 patients (vitamin B12 + Goshajinkigan treatment). The observation period was 6 weeks following treatment initiation, and the evaluation items were as follows: i) the current perception threshold (CPT value) of the peripheral nerve, ii) visual analogue scale for numbness, iii) National Cancer Institute Common Terminology Criteria for Adverse Events v3.0 grade of neurotoxicity, and iv) a questionnaire on the subjective symptoms of peripheral neuropathy (functional assessment of cancer therapy-taxane). These were compared between the groups and no significant differences were noted in any item. However, CTCAE grade 3 neurotoxicity developed in 2 patients (14.3%) after 6 weeks of administration in Group A, whereas no neurotoxicity was observed in Group B. When the change in the frequency of abnormal CPT ratio at 6 weeks of administration from that before treatment was compared between the groups, the frequency of abnormal value was significantly lower in Group B than in Group A (p<0.05). This suggests that Goshajinkigan inhibits the progression of peripheral neuropathy.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Objective evaluation of the alleviating effects of Goshajinkigan on peripheral neuropathy induced by paclitaxel/carboplatin therapy: A multicenter collaborative Study

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