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Article

Decrease in Fas-induced apoptosis by the γ-secretase inhibitor is dependent on p75NTR in a glioblastoma cell line

  • Authors:
    • Barbara Bessette
    • Karine Durand
    • Stéphanie Giraud
    • Gaëlle Bégaud
    • Muriel Mathonnet
    • Fabrice Lalloué
  • View Affiliations / Copyright

    Affiliations: University of Limoges, EA3842, ‘Cellular Homeostasis and Pathology’, Faculty of Medicine, 87025 Limoges Cedex, France
  • Pages: 873-877
    |
    Published online on: February 13, 2012
       https://doi.org/10.3892/etm.2012.480
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Abstract

p75NTR, a member of the tumor necrosis factor superfamily, plays a key role in numerous physiological processes, including cell survival or apoptosis. Yet, the associated signaling pathways remain poorly understood. Similar to Notch, γ-secretase cleavage is implicated in the p75NTR signaling pathway leading to nuclear translocation of the intracellular domain and cell death. Fas receptor activation was found to promote cell death apoptosis in several cell lines. The goal of this study was to determine the respective role of p75NTR and Notch in the resistance to Fas-induced apoptosis in the U-87 MG glioblastoma cell line. Using the γ-secretase inhibitor, we investigated the modulation of Fas-induced apoptosis dependent on p75NTR-Fas receptor interaction. Whereas the U-87 MG cells expressed the Fas receptor at the cell membrane, apoptosis induced by Fas activation was decreased by the γ-secretase inhibitor. These data suggest that γ-secretase is implicated in p75NTR and Fas interaction leading to cell death signaling.
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Copy and paste a formatted citation
Spandidos Publications style
Bessette B, Durand K, Giraud S, Bégaud G, Mathonnet M and Lalloué F: Decrease in Fas-induced apoptosis by the γ-secretase inhibitor is dependent on p75NTR in a glioblastoma cell line. Exp Ther Med 3: 873-877, 2012.
APA
Bessette, B., Durand, K., Giraud, S., Bégaud, G., Mathonnet, M., & Lalloué, F. (2012). Decrease in Fas-induced apoptosis by the γ-secretase inhibitor is dependent on p75NTR in a glioblastoma cell line. Experimental and Therapeutic Medicine, 3, 873-877. https://doi.org/10.3892/etm.2012.480
MLA
Bessette, B., Durand, K., Giraud, S., Bégaud, G., Mathonnet, M., Lalloué, F."Decrease in Fas-induced apoptosis by the γ-secretase inhibitor is dependent on p75NTR in a glioblastoma cell line". Experimental and Therapeutic Medicine 3.5 (2012): 873-877.
Chicago
Bessette, B., Durand, K., Giraud, S., Bégaud, G., Mathonnet, M., Lalloué, F."Decrease in Fas-induced apoptosis by the γ-secretase inhibitor is dependent on p75NTR in a glioblastoma cell line". Experimental and Therapeutic Medicine 3, no. 5 (2012): 873-877. https://doi.org/10.3892/etm.2012.480
Copy and paste a formatted citation
x
Spandidos Publications style
Bessette B, Durand K, Giraud S, Bégaud G, Mathonnet M and Lalloué F: Decrease in Fas-induced apoptosis by the γ-secretase inhibitor is dependent on p75NTR in a glioblastoma cell line. Exp Ther Med 3: 873-877, 2012.
APA
Bessette, B., Durand, K., Giraud, S., Bégaud, G., Mathonnet, M., & Lalloué, F. (2012). Decrease in Fas-induced apoptosis by the γ-secretase inhibitor is dependent on p75NTR in a glioblastoma cell line. Experimental and Therapeutic Medicine, 3, 873-877. https://doi.org/10.3892/etm.2012.480
MLA
Bessette, B., Durand, K., Giraud, S., Bégaud, G., Mathonnet, M., Lalloué, F."Decrease in Fas-induced apoptosis by the γ-secretase inhibitor is dependent on p75NTR in a glioblastoma cell line". Experimental and Therapeutic Medicine 3.5 (2012): 873-877.
Chicago
Bessette, B., Durand, K., Giraud, S., Bégaud, G., Mathonnet, M., Lalloué, F."Decrease in Fas-induced apoptosis by the γ-secretase inhibitor is dependent on p75NTR in a glioblastoma cell line". Experimental and Therapeutic Medicine 3, no. 5 (2012): 873-877. https://doi.org/10.3892/etm.2012.480
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