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Article

Video-assisted thoracoscopic surgery versus open lobectomy for stage I lung cancer: A meta-analysis of long-term outcomes

  • Authors:
    • Zhengjun Li
    • Hongxu Liu
    • Le Li
  • View Affiliations / Copyright

    Affiliations: Department of Thoracic Surgery, First Affiliated Hospital, China Medical University, Shenyang, Liaoning 110001, P.R. China, Department of General Surgery, First Affiliated Hospital, China Medical University, Shenyang, Liaoning 110001, P.R. China
  • Pages: 886-892
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    Published online on: February 13, 2012
       https://doi.org/10.3892/etm.2012.485
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Abstract

The present study aimed to evaluate the evidence comparing video-assisted thoracoscopic surgery (VATS) and open lobectomy for the treatment of stage I lung cancer using meta-analytical techniques. A literature search was undertaken until July 2011 to identify comparative studies evaluating survival rates, recurrence rates and complications. Pooled odds ratios (OR) and 95% confidence intervals (95% CI) were calculated with either the fixed- or random-effects model. These studies included a total of 1,362 patients: 668 treated with VATS and 694 treated with open lobectomy. The overall survival was significantly higher in patients treated with VATS than with open thoracotomy (OR=2.01, 95% CI 1.44-2.78) at 5 years. However, there was no statistically significant difference in 1.3-year overall survival between the VATS and open lobectomy groups (OR=3.21, 95% CI 0.77-13.40; OR=0.91, 95% CI 0.49-1.70). The data did not demonstrate a significant difference in locoregional recurrence (OR=0.58, 95% CI 0.33‑1.03) compared to the open lobectomy group, but suggested a reduced systemic recurrence rate (OR=0.52, 95% CI 0.23-0.82) and complications (OR=0.36, 95% CI 0.23‑0.57) of VATS. VATS was superior to open lobectomy for the prognosis of stage I lung cancer. However, the findings have to be carefully interpreted due to the lower levels of evidence.
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Copy and paste a formatted citation
Spandidos Publications style
Li Z, Liu H and Li L: Video-assisted thoracoscopic surgery versus open lobectomy for stage I lung cancer: A meta-analysis of long-term outcomes. Exp Ther Med 3: 886-892, 2012.
APA
Li, Z., Liu, H., & Li, L. (2012). Video-assisted thoracoscopic surgery versus open lobectomy for stage I lung cancer: A meta-analysis of long-term outcomes. Experimental and Therapeutic Medicine, 3, 886-892. https://doi.org/10.3892/etm.2012.485
MLA
Li, Z., Liu, H., Li, L."Video-assisted thoracoscopic surgery versus open lobectomy for stage I lung cancer: A meta-analysis of long-term outcomes". Experimental and Therapeutic Medicine 3.5 (2012): 886-892.
Chicago
Li, Z., Liu, H., Li, L."Video-assisted thoracoscopic surgery versus open lobectomy for stage I lung cancer: A meta-analysis of long-term outcomes". Experimental and Therapeutic Medicine 3, no. 5 (2012): 886-892. https://doi.org/10.3892/etm.2012.485
Copy and paste a formatted citation
x
Spandidos Publications style
Li Z, Liu H and Li L: Video-assisted thoracoscopic surgery versus open lobectomy for stage I lung cancer: A meta-analysis of long-term outcomes. Exp Ther Med 3: 886-892, 2012.
APA
Li, Z., Liu, H., & Li, L. (2012). Video-assisted thoracoscopic surgery versus open lobectomy for stage I lung cancer: A meta-analysis of long-term outcomes. Experimental and Therapeutic Medicine, 3, 886-892. https://doi.org/10.3892/etm.2012.485
MLA
Li, Z., Liu, H., Li, L."Video-assisted thoracoscopic surgery versus open lobectomy for stage I lung cancer: A meta-analysis of long-term outcomes". Experimental and Therapeutic Medicine 3.5 (2012): 886-892.
Chicago
Li, Z., Liu, H., Li, L."Video-assisted thoracoscopic surgery versus open lobectomy for stage I lung cancer: A meta-analysis of long-term outcomes". Experimental and Therapeutic Medicine 3, no. 5 (2012): 886-892. https://doi.org/10.3892/etm.2012.485
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