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Article

Sequence polymorphisms of the mitochondrial displacement loop and outcome of non-small cell lung cancer

  • Authors:
    • Cuimin Ding
    • Ruijuan Li
    • Ping Wang
    • Haiyan Fan
    • Zhanjun Guo
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory Medicine, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China, Department of Gastroenterology and Hepatology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China
  • Pages: 861-864
    |
    Published online on: February 17, 2012
       https://doi.org/10.3892/etm.2012.490
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Abstract

Accumulation of single-nucleotide polymorphisms (SNPs) in the displacement loop (D-loop) of mitochondrial DNA (mtDNA) may be associated with disease outcome. Our team investigated the prediction power of D-loop SNPs in non-small cell lung cancer (NSCLC) outcome. In an overall multivariate analysis, allele 16390 was identified as an independent predictor for NSCLC outcome. The length of survival of patients with allele 16390A was significantly shorter than that of patients with allele 16390G (relative risk, 0.323; 95% CI, 0.109-0.951; p=0.040). The analysis of genetic polymorphisms in the mitochondrial D-loop can help identify NSCLC patient subgroups at a high risk for a poor disease outcome.
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Copy and paste a formatted citation
Spandidos Publications style
Ding C, Li R, Wang P, Fan H and Guo Z: Sequence polymorphisms of the mitochondrial displacement loop and outcome of non-small cell lung cancer. Exp Ther Med 3: 861-864, 2012.
APA
Ding, C., Li, R., Wang, P., Fan, H., & Guo, Z. (2012). Sequence polymorphisms of the mitochondrial displacement loop and outcome of non-small cell lung cancer. Experimental and Therapeutic Medicine, 3, 861-864. https://doi.org/10.3892/etm.2012.490
MLA
Ding, C., Li, R., Wang, P., Fan, H., Guo, Z."Sequence polymorphisms of the mitochondrial displacement loop and outcome of non-small cell lung cancer". Experimental and Therapeutic Medicine 3.5 (2012): 861-864.
Chicago
Ding, C., Li, R., Wang, P., Fan, H., Guo, Z."Sequence polymorphisms of the mitochondrial displacement loop and outcome of non-small cell lung cancer". Experimental and Therapeutic Medicine 3, no. 5 (2012): 861-864. https://doi.org/10.3892/etm.2012.490
Copy and paste a formatted citation
x
Spandidos Publications style
Ding C, Li R, Wang P, Fan H and Guo Z: Sequence polymorphisms of the mitochondrial displacement loop and outcome of non-small cell lung cancer. Exp Ther Med 3: 861-864, 2012.
APA
Ding, C., Li, R., Wang, P., Fan, H., & Guo, Z. (2012). Sequence polymorphisms of the mitochondrial displacement loop and outcome of non-small cell lung cancer. Experimental and Therapeutic Medicine, 3, 861-864. https://doi.org/10.3892/etm.2012.490
MLA
Ding, C., Li, R., Wang, P., Fan, H., Guo, Z."Sequence polymorphisms of the mitochondrial displacement loop and outcome of non-small cell lung cancer". Experimental and Therapeutic Medicine 3.5 (2012): 861-864.
Chicago
Ding, C., Li, R., Wang, P., Fan, H., Guo, Z."Sequence polymorphisms of the mitochondrial displacement loop and outcome of non-small cell lung cancer". Experimental and Therapeutic Medicine 3, no. 5 (2012): 861-864. https://doi.org/10.3892/etm.2012.490
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