Association study between polymorphisms of the PARD3 gene and schizophrenia

Kim,Su Kang; Lee,Jong Yoon; Park,Hae Jeong; Kim,Jong Woo; Chung,Joo-Ho

doi:10.3892/etm.2012.496

May 2012 Volume 3 Issue 5

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May 2012 Volume 3 Issue 5

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Article

Association study between polymorphisms of the PARD3 gene and schizophrenia

Authors:
- Su Kang Kim
- Jong Yoon Lee
- Hae Jeong Park
- Jong Woo Kim
- Joo-Ho Chung
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Affiliations: Department of Pharmacology and Kohwang Medical Research Institute, Kyung Hee University, Seoul 130-701, Republic of Korea, School of Medicine, Kyung Hee University, Seoul 130-701, Republic of Korea, Department of Pharmacology and Kohwang Medical Research Institute, Kyung Hee University, Seoul 130-702, Republic of Korea, Department of Neuropsychiatry, School of Medicine, Kyung Hee University, Seoul 130-702, Republic of Korea
Pages: 881-885
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Published online on: February 23, 2012

https://doi.org/10.3892/etm.2012.496
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Abstract

The aim of this study was to investigate whether par-3 partitioning defective 3 homolog (C. elegans) (PARD3) single nucleotide polymorphisms (SNPs) are associated with schizophrenia. A total of 204 Korean schizophrenic patients [117 male, 41.1±9.6 years (mean age ± SD); 87 female, 42.6±11.5] and 351 control subjects (170 male, 43.8±6.6 years; 181 female, 44.2±5.8) were enrolled. We genotyped nine SNPs of the PARD3 gene [rs7075263 (intron), rs10827392 (intron), rs773970 (intron), rs2252655 (intron), rs10763984 (intron), rs3781128 (Ser889Ser), rs1936429 (intron), rs671228 (intron) and rs16935163 (intron)]. Genotypes of PARD3 polymorphisms were evaluated by direct sequencing. We used SNPStats, SPSS 18.0 and Haploview 4.2 software for analysis of genetic data. Multiple logistic regression models were used to calculate the odds ratio (OR), 95% confidence interval (CI), and corresponding p‑values (p), controlling for age and gender as covariables. Allele frequencies of the PARD3 SNPs were significantly associated with schizophrenia (rs3781128, p=0.041; rs1936429, p=0.030; rs671228, p=0.028). Certain genotype frequencies of the PARD3 SNPs also showed significant associations with schizophrenia (p<0.05, rs7075263, rs773970, rs2252655, rs10763984, rs3781128, rs1936429, rs16935163). To the best of our knowledge, this is the first report showing that PARD3 is associated with susceptibility to schizophrenia in a Korean population. In conclusion, our findings suggest that PARD3 may contribute to genetic susceptibility to schizophrenia.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Association study between polymorphisms of the PARD3 gene and schizophrenia

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Abstract

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