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Article

Braf and erbB2 mutations correlate with smoking status in lung cancer patients

  • Authors:
    • Hidefumi Sasaki
    • Masayuki Shitara
    • Keisuke Yokota
    • Katsuhiro Okuda
    • Yu Hikosaka
    • Satoru Moriyama
    • Motoki Yano
    • Yoshitaka Fujii
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Immunology and Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8601, Japan
  • Pages: 771-775
    |
    Published online on: March 1, 2012
       https://doi.org/10.3892/etm.2012.500
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Abstract

The erbB pathway involves a family of tyrosine kinases and contributes to resistance or sensitivity to chemotherapy in many tumor types. Somatic mutations of the epidermal growth factor receptor (EGFR) gene at the kinase domain have been found in lung cancer patients. These mutations are correlated with clinical response to targeted molecular therapy. Although Caucasian lung cancer patients have been shown to harbor Braf and erbB2 mutations, only a few reports exist concerning Braf and erbB2 mutations in Japanese lung cancer patients. We investigated the Braf and erbB2 mutation status in non-small cell lung cancer (NSCLC) patients by reverse transcription-polymerase chain reaction (RT-PCR) and direct sequencing. The study included 305 surgically removed lung cancer samples from the Nagoya City University Hospital, which were EGFR and Kras wild-type centric. Six Braf mutations were found in the adenocarcinoma cases. Among the adenocarcinoma cases, Braf mutations were more frequently noted in heavy smokers (Brinkman index >400, p=0.0476). We also detected five erbB2 mutations all in the non-smokers. All of these mutations existed exclusively. The erbB2 gene mutations were predominantly found in non-smokers with adenocarcinomas. However, the completely exclusive mutation status could help us design individually tailored targeted molecular therapy for lung cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Sasaki H, Shitara M, Yokota K, Okuda K, Hikosaka Y, Moriyama S, Yano M and Fujii Y: Braf and erbB2 mutations correlate with smoking status in lung cancer patients. Exp Ther Med 3: 771-775, 2012.
APA
Sasaki, H., Shitara, M., Yokota, K., Okuda, K., Hikosaka, Y., Moriyama, S. ... Fujii, Y. (2012). Braf and erbB2 mutations correlate with smoking status in lung cancer patients. Experimental and Therapeutic Medicine, 3, 771-775. https://doi.org/10.3892/etm.2012.500
MLA
Sasaki, H., Shitara, M., Yokota, K., Okuda, K., Hikosaka, Y., Moriyama, S., Yano, M., Fujii, Y."Braf and erbB2 mutations correlate with smoking status in lung cancer patients". Experimental and Therapeutic Medicine 3.5 (2012): 771-775.
Chicago
Sasaki, H., Shitara, M., Yokota, K., Okuda, K., Hikosaka, Y., Moriyama, S., Yano, M., Fujii, Y."Braf and erbB2 mutations correlate with smoking status in lung cancer patients". Experimental and Therapeutic Medicine 3, no. 5 (2012): 771-775. https://doi.org/10.3892/etm.2012.500
Copy and paste a formatted citation
x
Spandidos Publications style
Sasaki H, Shitara M, Yokota K, Okuda K, Hikosaka Y, Moriyama S, Yano M and Fujii Y: Braf and erbB2 mutations correlate with smoking status in lung cancer patients. Exp Ther Med 3: 771-775, 2012.
APA
Sasaki, H., Shitara, M., Yokota, K., Okuda, K., Hikosaka, Y., Moriyama, S. ... Fujii, Y. (2012). Braf and erbB2 mutations correlate with smoking status in lung cancer patients. Experimental and Therapeutic Medicine, 3, 771-775. https://doi.org/10.3892/etm.2012.500
MLA
Sasaki, H., Shitara, M., Yokota, K., Okuda, K., Hikosaka, Y., Moriyama, S., Yano, M., Fujii, Y."Braf and erbB2 mutations correlate with smoking status in lung cancer patients". Experimental and Therapeutic Medicine 3.5 (2012): 771-775.
Chicago
Sasaki, H., Shitara, M., Yokota, K., Okuda, K., Hikosaka, Y., Moriyama, S., Yano, M., Fujii, Y."Braf and erbB2 mutations correlate with smoking status in lung cancer patients". Experimental and Therapeutic Medicine 3, no. 5 (2012): 771-775. https://doi.org/10.3892/etm.2012.500
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