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Albuminuria-reducing effect of angiotensin II receptor blocker plus hydrochlorothiazide combination therapy in renal transplant recipients

  • Authors:
    • Toshihide Naganuma
    • Yoshiaki Takemoto
    • Junji Uchida
    • Taiyou Ootoshi
    • Nobuyuki Kuwabara
    • Satoshi Maeda
    • Tatsuya Nakatani
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Osaka City University Graduate School of Medicine, Osaka, Japan
  • Pages: 105-108
    |
    Published online on: April 11, 2012
       https://doi.org/10.3892/etm.2012.542
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Abstract

In recent years, the combined use of angiotensin II receptor blockers (ARBs) and low-dose diuretics has become clinically possible. Moreover, the GUARD and J-CORE studies have confirmed that the addition of low-dose diuretics to renin-angiotensin system inhibitors reduces albuminuria. In this study, we investigated the clinical effects of a combination drug containing an ARB and a low-dose diuretic in renal transplant recipients. A total of 13 renal transplant recipients who were receiving the maximum dose of the ARB and presenting with microalbuminuria [urine albumin-creatinine ratio (ACR) of 30-300 mg/g-Cre] were converted to a single pill combination drug containing the same amount of the ARB and 12.5 mg of hydrochlorothiazide (HCTZ) and an intervention study of a crossover trial design was conducted. The clinical parameters were measured at baseline, 3 months after ARB/HCTZ conversion and 3 months after reverting to the ARB and the resulting data were compared. Serum creatinine (S-Cre) and uric acid (UA) levels at 3 months after conversion were significantly higher than those at baseline. The levels of the estimated glomerular filtration rate (eGFR) and ACR at 3 months were significantly lower than those at baseline. S-Cre and UA levels at 3 months after reversion were significantly lower than those at 3 months after conversion. The eGFR and levels of ACR and UA at 3 months after ARB reversion were significantly higher than those at 3 months after conversion. The results of this preliminary study suggest that the combination drug containing an ARB and low-dose diuretic was effective for reducing microalbuminuria in renal transplant recipients. In the future, larger cohort studies are needed to confirm these findings.
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Copy and paste a formatted citation
Spandidos Publications style
Naganuma T, Takemoto Y, Uchida J, Ootoshi T, Kuwabara N, Maeda S and Nakatani T: Albuminuria-reducing effect of angiotensin II receptor blocker plus hydrochlorothiazide combination therapy in renal transplant recipients. Exp Ther Med 4: 105-108, 2012.
APA
Naganuma, T., Takemoto, Y., Uchida, J., Ootoshi, T., Kuwabara, N., Maeda, S., & Nakatani, T. (2012). Albuminuria-reducing effect of angiotensin II receptor blocker plus hydrochlorothiazide combination therapy in renal transplant recipients. Experimental and Therapeutic Medicine, 4, 105-108. https://doi.org/10.3892/etm.2012.542
MLA
Naganuma, T., Takemoto, Y., Uchida, J., Ootoshi, T., Kuwabara, N., Maeda, S., Nakatani, T."Albuminuria-reducing effect of angiotensin II receptor blocker plus hydrochlorothiazide combination therapy in renal transplant recipients". Experimental and Therapeutic Medicine 4.1 (2012): 105-108.
Chicago
Naganuma, T., Takemoto, Y., Uchida, J., Ootoshi, T., Kuwabara, N., Maeda, S., Nakatani, T."Albuminuria-reducing effect of angiotensin II receptor blocker plus hydrochlorothiazide combination therapy in renal transplant recipients". Experimental and Therapeutic Medicine 4, no. 1 (2012): 105-108. https://doi.org/10.3892/etm.2012.542
Copy and paste a formatted citation
x
Spandidos Publications style
Naganuma T, Takemoto Y, Uchida J, Ootoshi T, Kuwabara N, Maeda S and Nakatani T: Albuminuria-reducing effect of angiotensin II receptor blocker plus hydrochlorothiazide combination therapy in renal transplant recipients. Exp Ther Med 4: 105-108, 2012.
APA
Naganuma, T., Takemoto, Y., Uchida, J., Ootoshi, T., Kuwabara, N., Maeda, S., & Nakatani, T. (2012). Albuminuria-reducing effect of angiotensin II receptor blocker plus hydrochlorothiazide combination therapy in renal transplant recipients. Experimental and Therapeutic Medicine, 4, 105-108. https://doi.org/10.3892/etm.2012.542
MLA
Naganuma, T., Takemoto, Y., Uchida, J., Ootoshi, T., Kuwabara, N., Maeda, S., Nakatani, T."Albuminuria-reducing effect of angiotensin II receptor blocker plus hydrochlorothiazide combination therapy in renal transplant recipients". Experimental and Therapeutic Medicine 4.1 (2012): 105-108.
Chicago
Naganuma, T., Takemoto, Y., Uchida, J., Ootoshi, T., Kuwabara, N., Maeda, S., Nakatani, T."Albuminuria-reducing effect of angiotensin II receptor blocker plus hydrochlorothiazide combination therapy in renal transplant recipients". Experimental and Therapeutic Medicine 4, no. 1 (2012): 105-108. https://doi.org/10.3892/etm.2012.542
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