A variant allele of ADH1B and ALDH2, is associated with the risk of esophageal cancer

Gu,Haiyong; Gong,Dingxu; Ding,Guowen; Zhang,Wenbo; Liu,Chao; Jiang,Pengcheng; Chen,Suocheng; Chen,Yijang

doi:10.3892/etm.2012.547

A variant allele of ADH1B and ALDH2, is associated with the risk of esophageal cancer

Authors:
- Haiyong Gu
- Dingxu Gong
- Guowen Ding
- Wenbo Zhang
- Chao Liu
- Pengcheng Jiang
- Suocheng Chen
- Yijang Chen
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Affiliations: Department of Cardiothoracic Surgery, Affiliated People's Hospital of Jiangsu University, Zhenjiang 212000, P.R. China, Department of Surgery, State Key Laboratory of Translational Cardiovascular Medicine, Fuwai Hospital and Cardiovascular Institute, Chinese Academy of Medical Science, Peking Union Medical College, Beijing 100037, P.R. China, Department of General Surgery, Affiliated People's Hospital of Jiangsu University, Zhenjiang 212000, P.R. China, Department of Thoracic and Cardiac Surgery, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, P.R. China
Published online on: April 17, 2012 https://doi.org/10.3892/etm.2012.547
Pages: 135-140

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Abstract

Alcoholic beverages are causally related to esophageal cancer. The genetic polymorphisms of the alcohol‑metabolizing enzymes ADH1B rs1229984 and ALDH2 rs671 may modulate individual differences in alcohol‑oxidizing capability. A case‑control study was conducted to evaluate the genetic effects of these two functional single nucleotide polymorphisms (SNPs) on the development of esophageal cancer. A total of 380 esophageal squamous cell carcinoma cases and 380 controls were recruited. Genotypes were determined by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Variant alleles of the functional polymorphism ADH1B rs1229984 SNP were associated with an increased risk of esophageal cancer [adjusted odds ratio (OR)=2.39, 95% confidence interval (CI)=1.42-4.03 for ADH1B rs1229984 GG vs. AA]. There was a borderline-significantly decreased risk between the ALDH2 rs671 genotype and esophageal cancer (adjusted OR=0.47, 95% CI=0.22-1.00 for ALDH2 rs671 AA vs. GG). Stratified analyses indicated that both of these effects were more evident among male, younger subjects and smokers. In conclusion, the functional polymorphisms ADH1B rs1229984 and ALDH2 rs671 may contribute to susceptibility to esophageal cancer, particularly among male, younger subjects and smokers.

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