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Article

Scorpion venom component III inhibits cell proliferation by modulating NF-κB activation in human leukemia cells

  • Authors:
    • Xiangfeng Song
    • Guojun Zhang
    • Aiping Sun
    • Jiqiang Guo
    • Zhongwei Tian
    • Hui Wang
    • Yufeng Liu
  • View Affiliations / Copyright

    Affiliations: Department of Pediatrics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, P.R. China, Department of Immunology, Xinxiang Medical University, Xinxiang, Henan, P.R. China, Department of Dermatology, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan, P.R. China
  • Pages: 146-150
    |
    Published online on: April 17, 2012
       https://doi.org/10.3892/etm.2012.548
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Abstract

Scorpion venom contains various groups of compounds that exhibit anticancer activity against a variety of malignancies through a poorly understood mechanism. While the aberrant activation of nuclear factor κB (NF‑κB) has been linked with hematopoietic malignancies, we hypothesized that scorpion venom mediates its effects by modulating the NF‑κB signaling pathway. In the present study, we examined the effects of scorpion venom component III (SVCIII) on the human leukemia cell lines THP‑1 and Jurkat and focused on the NF‑κB signaling pathway. Our results showed that SVCIII inhibited cell proliferation, caused cell cycle arrest at G1 phase and inhibited the expression of cell cycle regulatory protein cyclin D1 in a dose-dependent manner in THP‑1 and Jurkat cells. SVCIII also suppressed the constitutive NF‑κB activation through inhibition of the phosphorylation and degradation of IκBα. NF‑κB luciferase reporter activity was also inhibited by SVCIII. Our data suggest that SVCIII, a natural compound, may exert its antiproliferative effects by inhibiting the activation of NF‑κB and, thus, has potential use in the treatment of hematopoietic malignancies, alone or in combination with other agents.
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Copy and paste a formatted citation
Spandidos Publications style
Song X, Zhang G, Sun A, Guo J, Tian Z, Wang H and Liu Y: Scorpion venom component III inhibits cell proliferation by modulating NF-κB activation in human leukemia cells. Exp Ther Med 4: 146-150, 2012.
APA
Song, X., Zhang, G., Sun, A., Guo, J., Tian, Z., Wang, H., & Liu, Y. (2012). Scorpion venom component III inhibits cell proliferation by modulating NF-κB activation in human leukemia cells. Experimental and Therapeutic Medicine, 4, 146-150. https://doi.org/10.3892/etm.2012.548
MLA
Song, X., Zhang, G., Sun, A., Guo, J., Tian, Z., Wang, H., Liu, Y."Scorpion venom component III inhibits cell proliferation by modulating NF-κB activation in human leukemia cells". Experimental and Therapeutic Medicine 4.1 (2012): 146-150.
Chicago
Song, X., Zhang, G., Sun, A., Guo, J., Tian, Z., Wang, H., Liu, Y."Scorpion venom component III inhibits cell proliferation by modulating NF-κB activation in human leukemia cells". Experimental and Therapeutic Medicine 4, no. 1 (2012): 146-150. https://doi.org/10.3892/etm.2012.548
Copy and paste a formatted citation
x
Spandidos Publications style
Song X, Zhang G, Sun A, Guo J, Tian Z, Wang H and Liu Y: Scorpion venom component III inhibits cell proliferation by modulating NF-κB activation in human leukemia cells. Exp Ther Med 4: 146-150, 2012.
APA
Song, X., Zhang, G., Sun, A., Guo, J., Tian, Z., Wang, H., & Liu, Y. (2012). Scorpion venom component III inhibits cell proliferation by modulating NF-κB activation in human leukemia cells. Experimental and Therapeutic Medicine, 4, 146-150. https://doi.org/10.3892/etm.2012.548
MLA
Song, X., Zhang, G., Sun, A., Guo, J., Tian, Z., Wang, H., Liu, Y."Scorpion venom component III inhibits cell proliferation by modulating NF-κB activation in human leukemia cells". Experimental and Therapeutic Medicine 4.1 (2012): 146-150.
Chicago
Song, X., Zhang, G., Sun, A., Guo, J., Tian, Z., Wang, H., Liu, Y."Scorpion venom component III inhibits cell proliferation by modulating NF-κB activation in human leukemia cells". Experimental and Therapeutic Medicine 4, no. 1 (2012): 146-150. https://doi.org/10.3892/etm.2012.548
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