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Experimental and Therapeutic Medicine
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Print ISSN: 1792-0981 Online ISSN: 1792-1015
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July 2012 Volume 4 Issue 1

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Effect of Jagged1 on the proliferation and migration of colon cancer cells

  • Authors:
    • Yong Tan
    • Jingjing Peng
    • Dong Wei
    • Peng Chen
    • Yu Zhao

  • View Affiliations / Copyright

    Affiliations: Department of Oncology, The General Hospital of Chengdu Military Region, Chengdu 610083, P.R. China
  • Pages: 89-92
    |
    Published online on: April 17, 2012
       https://doi.org/10.3892/etm.2012.549
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Abstract

The aim of this study was to determine the effect of Jagged1 on the proliferation and migration of colon cancer cells. HT-29 colorectal carcinoma cells were transfected with adenovirus carrying either the Jagged1 gene (Ad-Jagged1) or Jagged1 small interfering RNA (siRNA) (Ad-si/hJagged1). The protein was detected using western blot analysis. The proliferation of cells was observed by assessing the incorporation of [3H]-thymidine. The migration of cells was detected using a modified Boyden chamber assay. The level of Jagged1 protein increased by 2.8-fold with Ad-Jagged1 transfection and decreased by 70% with Ad-si/hJagged1 transfection. Proliferation, migration and p-Akt protein expression were enhanced in the Ad-Jagged1-transfected group compared to that in the non-transfected control group. In addition, the proliferation, migration and phosphorylated Akt protein expression were reduced in the Ad-si/hJagged1-transfected group compared to that in the non-transfected control group. The Jagged1 protein may promote proliferation and migration of colon cancer cells, which may be related to its effect on Akt phosphorylation.
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Copy and paste a formatted citation
Spandidos Publications style
Tan Y, Peng J, Wei D, Chen P and Zhao Y: Effect of Jagged1 on the proliferation and migration of colon cancer cells. Exp Ther Med 4: 89-92, 2012.
APA
Tan, Y., Peng, J., Wei, D., Chen, P., & Zhao, Y. (2012). Effect of Jagged1 on the proliferation and migration of colon cancer cells. Experimental and Therapeutic Medicine, 4, 89-92. https://doi.org/10.3892/etm.2012.549
MLA
Tan, Y., Peng, J., Wei, D., Chen, P., Zhao, Y."Effect of Jagged1 on the proliferation and migration of colon cancer cells". Experimental and Therapeutic Medicine 4.1 (2012): 89-92.
Chicago
Tan, Y., Peng, J., Wei, D., Chen, P., Zhao, Y."Effect of Jagged1 on the proliferation and migration of colon cancer cells". Experimental and Therapeutic Medicine 4, no. 1 (2012): 89-92. https://doi.org/10.3892/etm.2012.549
Copy and paste a formatted citation
x
Spandidos Publications style
Tan Y, Peng J, Wei D, Chen P and Zhao Y: Effect of Jagged1 on the proliferation and migration of colon cancer cells. Exp Ther Med 4: 89-92, 2012.
APA
Tan, Y., Peng, J., Wei, D., Chen, P., & Zhao, Y. (2012). Effect of Jagged1 on the proliferation and migration of colon cancer cells. Experimental and Therapeutic Medicine, 4, 89-92. https://doi.org/10.3892/etm.2012.549
MLA
Tan, Y., Peng, J., Wei, D., Chen, P., Zhao, Y."Effect of Jagged1 on the proliferation and migration of colon cancer cells". Experimental and Therapeutic Medicine 4.1 (2012): 89-92.
Chicago
Tan, Y., Peng, J., Wei, D., Chen, P., Zhao, Y."Effect of Jagged1 on the proliferation and migration of colon cancer cells". Experimental and Therapeutic Medicine 4, no. 1 (2012): 89-92. https://doi.org/10.3892/etm.2012.549
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