Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
July 2012 Volume 4 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July 2012 Volume 4 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Carnitine-induced senescence in glioblastoma cells

  • Authors:
    • Shuichi Yamada
    • Ryosuke Matsuda
    • Fumihiko Nishimura
    • Ichiro Nakagawa
    • Yasushi Motoyama
    • Young-Su Park
    • Mitsutoshi Nakamura
    • Hiroyuki Nakase
    • Yukiteru Ouji
    • Masahide Yoshikawa
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Nara Medical University, Kashihara, Nara, Japan, Department of Pathogen, Infection and Immunity, Nara Medical University, Kashihara, Nara, Japan
  • Pages: 21-25
    |
    Published online on: April 23, 2012
       https://doi.org/10.3892/etm.2012.556
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Carnitine is essential for lipid metabolism in cells and is known to possess antioxidant properties. Previous reports have suggested that antioxidants are able to induce senescence in glioblastoma cells, consequently, in the present study, we investigated the effect of carnitine on glioblastoma cells. Under conditions of hyponutrition (undernutrition), the proliferation of glioblastoma cells was attenuated and the level of intracellular carnitine was increased. Glioblastoma cell proliferation was also attenuated in cultures that were supplemented with exogenous carnitine, where the induction of senescence was detected by senescence-associated β-gal (SA-β-gal) staining. However, there was no evidence of the induction of apoptosis. These effects were not detected when cells were cultured with carnitine plus an inhibitor of p38 mitogen-activated protein kinase (MAPK). It, therefore, appears that carnitine has antioxidant actions in normal cells but induces senescence, which may be regarded as an opposite phenomenon, in glioblastoma cells. Senescence has been reported in cells exposed to temozolomide, which is a standard drug used for the treatment of glioblastoma. Carnitine could, therefore, represent an attractive alternative therapy for glioblastoma.
View Figures
View References

1 

Behin A, Hoang-Xuan K, Carpentier AF and Delattre JY: Primary brain tumours in adults. Lancet. 361:323–331. 2003. View Article : Google Scholar : PubMed/NCBI

2 

Preusser M, de Ribaupierre S, Wohrer A, et al: Current concepts and management of glioblastoma. Ann Neurol. 70:9–21. 2011. View Article : Google Scholar

3 

Lacroix M, Abi-Said D, Fourney DR, et al: A multivariate analysis of 416 patients with glioblastoma multiforme: prognosis, extent of resection, and survival. J Neurosurg. 95:190–198. 2001. View Article : Google Scholar : PubMed/NCBI

4 

Lefranc F, Sadeghi N, Camby I, Metens T, Dewitte O and Kiss R: Present and potential future issues in glioblastoma treatment. Expert Rev Anticancer Ther. 6:719–732. 2006. View Article : Google Scholar : PubMed/NCBI

5 

Ewald JA, Desotelle JA, Wilding G and Jarrard DF: Therapy-induced senescence in cancer. J Natl Cancer Inst. 102:1536–1546. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Kuilman T, Michaloglou C, Mooi WJ and Peeper DS: The essence of senescence. Genes Dev. 24:2463–2479. 2010. View Article : Google Scholar : PubMed/NCBI

7 

Rodier F and Campisi J: Four faces of cellular senescence. J Cell Biol. 192:547–556. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Campisi J: Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Cell. 120:513–522. 2005. View Article : Google Scholar : PubMed/NCBI

9 

Gewirtz DA, Holt SE and Elmore LW: Accelerated senescence: an emerging role in tumor cell response to chemotherapy and radiation. Biochem Pharmacol. 76:947–957. 2008. View Article : Google Scholar : PubMed/NCBI

10 

Roberson RS, Kussick SJ, Vallieres E, Chen SY and Wu DY: Escape from therapy-induced accelerated cellular senescence in p53-null lung cancer cells and in human lung cancers. Cancer Res. 65:2795–2803. 2005. View Article : Google Scholar : PubMed/NCBI

11 

Te Poele RH, Okorokov AL, Jardine L, Cummings J and Joel SP: DNA damage is able to induce senescence in tumor cells in vitro and in vivo. Cancer Res. 62:1876–1883. 2002.PubMed/NCBI

12 

Flanagan JL, Simmons PA, Vehige J, Willcox MD and Garrett Q: Role of carnitine in disease. Nutr Metab (Lond). 7:302010. View Article : Google Scholar : PubMed/NCBI

13 

Yano H, Oyanagi E, Kato Y, Samejima Y, Sasaki J and Utsumi K: L-carnitine is essential to beta-oxidation of quarried fatty acid from mitochondrial membrane by PLA(2). Mol Cell Biochem. 342:95–100. 2010. View Article : Google Scholar : PubMed/NCBI

14 

Wang C, Sadovova N, Ali HK, et al: L-carnitine protects neurons from 1-methyl-4-phenylpyridinium-induced neuronal apoptosis in rat forebrain culture. Neuroscience. 144:46–55. 2007. View Article : Google Scholar : PubMed/NCBI

15 

Revoltella RP, Dal Canto B, Caracciolo L and D’Urso CM: L-carnitine and some of its analogs delay the onset of apoptotic cell death initiated in murine C2.8 hepatocytic cells after hepatocyte growth factor deprivation. Biochim Biophys Acta. 1224:333–341. 1994. View Article : Google Scholar : PubMed/NCBI

16 

Sparagna GC, Hickson-Bick DL, Buja LM and McMillin JB: A metabolic role for mitochondria in palmitate-induced cardiac myocyte apoptosis. Am J Physiol Heart Circ Physiol. 279:H2124–H2132. 2000.PubMed/NCBI

17 

Chang B, Nishikawa M, Sato E, Utsumi K and Inoue M: L-Carnitine inhibits cisplatin-induced injury of the kidney and small intestine. Arch Biochem Biophys. 405:55–64. 2002. View Article : Google Scholar : PubMed/NCBI

18 

Calabrese V, Cornelius C, Stella AM and Calabrese EJ: Cellular stress responses, mitostress and carnitine insufficiencies as critical determinants in aging and neurodegenerative disorders: role of hormesis and vitagenes. Neurochem Res. 35:1880–1915. 2010. View Article : Google Scholar

19 

Rauchova H, Koudelova J, Drahota Z and Mourek J: Hypoxia-induced lipid peroxidation in rat brain and protective effect of carnitine and phosphocreatine. Neurochem Res. 27:899–904. 2002. View Article : Google Scholar : PubMed/NCBI

20 

Coulthard LR, White DE, Jones DL, McDermott MF and Burchill SA: p38(MAPK): stress responses from molecular mechanisms to therapeutics. Trends Mol Med. 15:369–379. 2009. View Article : Google Scholar : PubMed/NCBI

21 

Debacq-Chainiaux F, Boilan E, Dedessus Le Moutier J, Weemaels G and Toussaint O: p38 (MAPK) in the senescence of human and murine fibroblasts. Adv Exp Med Biol. 694:126–137. 2010. View Article : Google Scholar : PubMed/NCBI

22 

Malkoun N, Chargari C, Forest F, et al: Prolonged temozolomide for treatment of glioblastoma: preliminary clinical results and prognostic value of p53 overexpression. J Neurooncol. 106:127–133. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Stupp R, Mason WP, van den Bent MJ, et al: Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med. 352:987–996. 2005. View Article : Google Scholar : PubMed/NCBI

24 

Mhaidat NM, Zhang XD, Allen J, Avery-Kiejda KA, Scott RJ and Hersey P: Temozolomide induces senescence but not apoptosis in human melanoma cells. Br J Cancer. 97:1225–1233. 2007. View Article : Google Scholar : PubMed/NCBI

25 

De la Lastra CA and Villegas I: Resveratrol as an anti-inflammatory and anti-aging agent: mechanisms and clinical implications. Mol Nutr Food Res. 49:405–430. 2005.PubMed/NCBI

26 

Um JH, Park SJ, Kang H, et al: AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrol. Diabetes. 59:554–563. 2010. View Article : Google Scholar : PubMed/NCBI

27 

Zamin LL, Filippi-Chiela EC, Dillenburg-Pilla P, Horn F, Salbego C and Lenz G: Resveratrol and quercetin cooperate to induce senescence-like growth arrest in C6 rat glioma cells. Cancer Sci. 100:1655–1662. 2009. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Yamada S, Matsuda R, Nishimura F, Nakagawa I, Motoyama Y, Park Y, Nakamura M, Nakase H, Ouji Y, Yoshikawa M, Yoshikawa M, et al: Carnitine-induced senescence in glioblastoma cells. Exp Ther Med 4: 21-25, 2012.
APA
Yamada, S., Matsuda, R., Nishimura, F., Nakagawa, I., Motoyama, Y., Park, Y. ... Yoshikawa, M. (2012). Carnitine-induced senescence in glioblastoma cells. Experimental and Therapeutic Medicine, 4, 21-25. https://doi.org/10.3892/etm.2012.556
MLA
Yamada, S., Matsuda, R., Nishimura, F., Nakagawa, I., Motoyama, Y., Park, Y., Nakamura, M., Nakase, H., Ouji, Y., Yoshikawa, M."Carnitine-induced senescence in glioblastoma cells". Experimental and Therapeutic Medicine 4.1 (2012): 21-25.
Chicago
Yamada, S., Matsuda, R., Nishimura, F., Nakagawa, I., Motoyama, Y., Park, Y., Nakamura, M., Nakase, H., Ouji, Y., Yoshikawa, M."Carnitine-induced senescence in glioblastoma cells". Experimental and Therapeutic Medicine 4, no. 1 (2012): 21-25. https://doi.org/10.3892/etm.2012.556
Copy and paste a formatted citation
x
Spandidos Publications style
Yamada S, Matsuda R, Nishimura F, Nakagawa I, Motoyama Y, Park Y, Nakamura M, Nakase H, Ouji Y, Yoshikawa M, Yoshikawa M, et al: Carnitine-induced senescence in glioblastoma cells. Exp Ther Med 4: 21-25, 2012.
APA
Yamada, S., Matsuda, R., Nishimura, F., Nakagawa, I., Motoyama, Y., Park, Y. ... Yoshikawa, M. (2012). Carnitine-induced senescence in glioblastoma cells. Experimental and Therapeutic Medicine, 4, 21-25. https://doi.org/10.3892/etm.2012.556
MLA
Yamada, S., Matsuda, R., Nishimura, F., Nakagawa, I., Motoyama, Y., Park, Y., Nakamura, M., Nakase, H., Ouji, Y., Yoshikawa, M."Carnitine-induced senescence in glioblastoma cells". Experimental and Therapeutic Medicine 4.1 (2012): 21-25.
Chicago
Yamada, S., Matsuda, R., Nishimura, F., Nakagawa, I., Motoyama, Y., Park, Y., Nakamura, M., Nakase, H., Ouji, Y., Yoshikawa, M."Carnitine-induced senescence in glioblastoma cells". Experimental and Therapeutic Medicine 4, no. 1 (2012): 21-25. https://doi.org/10.3892/etm.2012.556
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team