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Article

Prognostic significance of membrane-associated mucins 1 and 4 in gastric adenocarcinoma

  • Authors:
    • Ilseon Hwang
    • Yu Na Kang
    • Jin Young Kim
    • Young Rok Do
    • Hong Suk Song
    • Keon Uk Park
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, School of Medicine, Keimyung University, Jung-gu, Daegu 700-712, Republic of Korea, Division of Hematology/Oncology, Department of Internal Medicine, School of Medicine, Keimyung University, Jung-gu, Daegu 700-712, Republic of Korea
  • Pages: 311-316
    |
    Published online on: June 1, 2012
       https://doi.org/10.3892/etm.2012.598
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Abstract

Aberrant expression of mucins is likely associated with cancer biology as alterations in the expression and/or glycosylation patterns of various mucins have been noted. Expression of the mucin family in gastric cancers has been reported in numerous studies, but the results are conflicting. Therefore, we investigated the potential use of mucin (MUC)1 and 4 as prognostic markers in gastric cancer according to histological subtype. Three-hundred and sixty-five gastric adenocarcinoma patients who underwent surgical resection were selected for this study. Among the 365 gastric cancer samples tested here, 34% consisted of early gastric cancer and 66% were advanced. In terms of location, 68.7% of the cohort had intestinal-type cancer and 30.7% had diffuse-type. We constructed tissue microarrays with formalin-fixed paraffin-embedded blocks of gastric cancer and these microarrays were evaluated for phenotypic expression of MUC1/4 using monoclonal antibodies. Two-hundred and ninety-two patients (92.7%) were positive for MUC1 and 216 (60.5%) were positive for MUC4. MUC1 expression was not correlated with any other clinicopathological variables such as age, gender, depth of invasion, lymph node metastasis, Lauren classification or recurrence. However, loss of MUC4 expression was significantly correlated with recurrence (p=0.033). MUC4 expression was also significantly correlated with better disease-free survival (p=0.049) and particularly in the intestinal-type (p=0.018). Our present findings demonstrated that loss of MUC4 expression can be used as a prognostic marker in gastric cancer. Loss of MUC4 expression is a prognostic indicator of increased recurrence and poor disease-free survival in patients with gastric cancer.
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1. 

Li XH, Zheng HC, Wang ZG, et al: The clinicopathological and prognostic significance of MUC-1 expression in Japanese gastric carcinomas: an immunohistochemical study of tissue micro-arrays. Anticancer Res. 28:1061–1067. 2008.PubMed/NCBI

2. 

Hollingsworth MA and Swanson BJ: Mucins in cancer: protection and control of the cell surface. Nat Rev Cancer. 4:45–60. 2004. View Article : Google Scholar : PubMed/NCBI

3. 

Zheng H, Takahashi H, Nakajima T, et al: MUC6 down-regulation correlates with gastric carcinoma progression and a poor prognosis: an immunohistochemical study with tissue micro-arrays. J Cancer Res Clin Oncol. 132:817–823. 2006. View Article : Google Scholar

4. 

Cozzi PJ, Wang J, Delprado W, et al: MUC1, MUC2, MUC4, MUC5AC and MUC6 expression in the progression of prostate cancer. Clin Exp Metastasis. 22:565–573. 2005. View Article : Google Scholar : PubMed/NCBI

5. 

Fattorossi A, Battaglia A, Malinconico P, et al: Constitutive and inducible expression of the epithelial antigen MUC1 (CD227) in human T cells. Exp Cell Res. 280:107–118. 2002. View Article : Google Scholar : PubMed/NCBI

6. 

Pandey P, Kharbanda S and Kufe D: Association of the DF3/MUC1 breast cancer antigen with Grb2 and the Sos/Ras exchange protein. Cancer Res. 55:4000–4003. 1995.PubMed/NCBI

7. 

Monges GM, Mathoulin-Portier MP, Acres RB, et al: Differential MUC 1 expression in normal and neoplastic human pancreatic tissue. An immunohistochemical study of 60 samples. Am J Clin Pathol. 112:635–640. 1999.PubMed/NCBI

8. 

Nakamori S, Ota DM, Cleary KR, Shirotani K and Irimura T: MUC1 mucin expression as a marker of progression and metastasis of human colorectal carcinoma. Gastroenterology. 106:353–361. 1994.PubMed/NCBI

9. 

Khodarev NN, Pitroda SP, Beckett MA, et al: MUC1-induced transcriptional programs associated with tumorigenesis predict outcome in breast and lung cancer. Cancer Res. 69:2833–2837. 2009. View Article : Google Scholar : PubMed/NCBI

10. 

Moniaux N, Escande F, Porchet N, Aubert JP and Batra SK: Structural organization and classification of the human mucin genes. Front Biosci. 6:D1192–D1206. 2001. View Article : Google Scholar : PubMed/NCBI

11. 

Ho SB, Niehans GA, Lyftogt C, et al: Heterogeneity of mucin gene expression in normal and neoplastic tissues. Cancer Res. 53:641–651. 1993.PubMed/NCBI

12. 

Jeon JM, Lee HW, Park JY, et al: Expression of MUC1 and MUC4 and its prognostic significance in non-small cell lung carcinoma. Korean J Pathol. 44:397–403. 2010. View Article : Google Scholar

13. 

Shibahara H, Tamada S, Higashi M, et al: MUC4 is a novel prognostic factor of intrahepatic cholangiocarcinoma-mass forming type. Hepatology. 39:220–229. 2004. View Article : Google Scholar : PubMed/NCBI

14. 

Tamada S, Shibahara H, Higashi M, et al: MUC4 is a novel prognostic factor of extrahepatic bile duct carcinoma. Clin Cancer Res. 12:4257–4264. 2006. View Article : Google Scholar : PubMed/NCBI

15. 

Saitou M, Goto M, Horinouchi M, et al: MUC4 expression is a novel prognostic factor in patients with invasive ductal carcinoma of the pancreas. J Clin Pathol. 58:845–852. 2005. View Article : Google Scholar : PubMed/NCBI

16. 

Tsutsumida H, Goto M, Kitajima S, et al: MUC4 expression correlates with poor prognosis in small-sized lung adenocarcinoma. Lung Cancer. 55:195–203. 2007. View Article : Google Scholar : PubMed/NCBI

17. 

Singh AP, Chauhan SC, Bafna S, et al: Aberrant expression of transmembrane mucins, MUC1 and MUC4, in human prostate carcinomas. Prostate. 66:421–429. 2006. View Article : Google Scholar : PubMed/NCBI

18. 

Kwon KY, Ro JY, Singhal N, et al: MUC4 expression in non-small cell lung carcinomas: relationship to tumor histology and patient survival. Arch Pathol Lab Med. 131:593–598. 2007.PubMed/NCBI

19. 

Weed DT, Gomez-Fernandez C, Pacheco J, et al: MUC4 and ERBB2 expression in major and minor salivary gland mucoepidermoid carcinoma. Head Neck. 26:353–364. 2004. View Article : Google Scholar : PubMed/NCBI

20. 

Alos L, Lujan B, Castillo M, et al: Expression of membrane-bound mucins (MUC1 and MUC4) and secreted mucins (MUC2, MUC5AC, MUC5B, MUC6 and MUC7) in mucoepidermoid carcinomas of salivary glands. Am J Surg Pathol. 29:806–813. 2005. View Article : Google Scholar : PubMed/NCBI

21. 

Weed DT, Gomez-Fernandez C, Yasin M, et al: MUC4 and ErbB2 expression in squamous cell carcinoma of the upper aerodigestive tract: correlation with clinical outcomes. Laryngoscope. 114:1–32. 2004. View Article : Google Scholar : PubMed/NCBI

22. 

Yonezawa S, Goto M, Yamada N, Higashi M and Nomoto M: Expression profiles of MUC1, MUC2, and MUC4 mucins in human neoplasms and their relationship with biological behavior. Proteomics. 8:3329–3341. 2008. View Article : Google Scholar : PubMed/NCBI

23. 

Akyurek N, Akyol G, Dursun A, Yamac D and Gunel N: Expression of MUC1 and MUC2 mucins in gastric carcinomas: their relationship with clinicopathologic parameters and prognosis. Pathol Res Pract. 198:665–674. 2002. View Article : Google Scholar : PubMed/NCBI

24. 

Utsunomiya T, Yonezawa S, Sakamoto H, et al: Expression of MUC1 and MUC2 mucins in gastric carcinomas: its relationship with the prognosis of the patients. Clin Cancer Res. 4:2605–2614. 1998.PubMed/NCBI

25. 

Westgaard A, Schjolberg AR, Cvancarova M, Eide TJ, Clausen OP and Gladhaug IP: Differentiation markers in pancreatic head adenocarcinomas: MUC1 and MUC4 expression indicates poor prognosis in pancreatobiliary differentiated tumours. Histopathology. 54:337–347. 2009. View Article : Google Scholar : PubMed/NCBI

26. 

Shanmugam C, Jhala NC, Katkoori VR, et al: Prognostic value of mucin 4 expression in colorectal adenocarcinomas. Cancer. 116:3577–3586. 2010. View Article : Google Scholar : PubMed/NCBI

27. 

Lopez-Ferrer A, de Bolos C, Barranco C, et al: Role of fucosyltransferases in the association between apomucin and Lewis antigen expression in normal and malignant gastric epithelium. Gut. 47:349–356. 2000. View Article : Google Scholar

28. 

Buisine MP, Devisme L, Maunoury V, et al: Developmental mucin gene expression in the gastroduodenal tract and accessory digestive glands. I. Stomach. A relationship to gastric carcinoma. J Histochem Cytochem. 48:1657–1666. 2000. View Article : Google Scholar : PubMed/NCBI

29. 

Senapati S, Chaturvedi P, Sharma P, et al: Deregulation of MUC4 in gastric adenocarcinoma: potential pathobiological implication in poorly differentiated non-signet ring cell type gastric cancer. Br J Cancer. 99:949–956. 2008. View Article : Google Scholar

30. 

Moniaux N, Nollet S, Porchet N, Degand P, Laine A and Aubert JP: Complete sequence of the human mucin MUC4: a putative cell membrane-associated mucin. Biochem J. 338:325–333. 1999. View Article : Google Scholar : PubMed/NCBI

31. 

Carraway KL III, Rossi EA, Komatsu M, et al: An intramembrane modulator of the ErbB2 receptor tyrosine kinase that potentiates neuregulin signaling. J Biol Chem. 274:5263–5266. 1999. View Article : Google Scholar : PubMed/NCBI

32. 

Carraway KL, Ramsauer VP, Haq B and Carothers Carraway CA: Cell signaling through membrane mucins. Bioessays. 25:66–71. 2003. View Article : Google Scholar : PubMed/NCBI

33. 

Jepson S, Komatsu M, Haq B, et al: Muc4/sialomucin complex, the intramembrane ErbB2 ligand, induces specific phosphorylation of ErbB2 and enhances expression of p27(kip), but does not activate mitogen-activated kinase or protein kinaseB/Akt pathways. Oncogene. 21:7524–7532. 2002. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Hwang I, Kang YN, Kim JY, Do YR, Song HS and Park KU: Prognostic significance of membrane-associated mucins 1 and 4 in gastric adenocarcinoma. Exp Ther Med 4: 311-316, 2012.
APA
Hwang, I., Kang, Y.N., Kim, J.Y., Do, Y.R., Song, H.S., & Park, K.U. (2012). Prognostic significance of membrane-associated mucins 1 and 4 in gastric adenocarcinoma. Experimental and Therapeutic Medicine, 4, 311-316. https://doi.org/10.3892/etm.2012.598
MLA
Hwang, I., Kang, Y. N., Kim, J. Y., Do, Y. R., Song, H. S., Park, K. U."Prognostic significance of membrane-associated mucins 1 and 4 in gastric adenocarcinoma". Experimental and Therapeutic Medicine 4.2 (2012): 311-316.
Chicago
Hwang, I., Kang, Y. N., Kim, J. Y., Do, Y. R., Song, H. S., Park, K. U."Prognostic significance of membrane-associated mucins 1 and 4 in gastric adenocarcinoma". Experimental and Therapeutic Medicine 4, no. 2 (2012): 311-316. https://doi.org/10.3892/etm.2012.598
Copy and paste a formatted citation
x
Spandidos Publications style
Hwang I, Kang YN, Kim JY, Do YR, Song HS and Park KU: Prognostic significance of membrane-associated mucins 1 and 4 in gastric adenocarcinoma. Exp Ther Med 4: 311-316, 2012.
APA
Hwang, I., Kang, Y.N., Kim, J.Y., Do, Y.R., Song, H.S., & Park, K.U. (2012). Prognostic significance of membrane-associated mucins 1 and 4 in gastric adenocarcinoma. Experimental and Therapeutic Medicine, 4, 311-316. https://doi.org/10.3892/etm.2012.598
MLA
Hwang, I., Kang, Y. N., Kim, J. Y., Do, Y. R., Song, H. S., Park, K. U."Prognostic significance of membrane-associated mucins 1 and 4 in gastric adenocarcinoma". Experimental and Therapeutic Medicine 4.2 (2012): 311-316.
Chicago
Hwang, I., Kang, Y. N., Kim, J. Y., Do, Y. R., Song, H. S., Park, K. U."Prognostic significance of membrane-associated mucins 1 and 4 in gastric adenocarcinoma". Experimental and Therapeutic Medicine 4, no. 2 (2012): 311-316. https://doi.org/10.3892/etm.2012.598
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