Alcohol abuse-related severe acute pancreatitis with rhabdomyolysis complications

Su,Mao-Sheng; Jiang,Ying; Yan,Xiao-Yuan  Hu; Zhao,Qing-Hua; Liu,Zhi-Wei; Zhang,Wen-Zhi; He,Lei

doi:10.3892/etm.2012.735

January 2013 Volume 5 Issue 1

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January 2013 Volume 5 Issue 1

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Article

Alcohol abuse-related severe acute pancreatitis with rhabdomyolysis complications

Authors:
- Mao-Sheng Su
- Ying Jiang
- Xiao-Yuan Hu Yan
- Qing-Hua Zhao
- Zhi-Wei Liu
- Wen-Zhi Zhang
- Lei He
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Affiliations: Department of Hepatobiliary Surgery, PLA General Hospital, Beijing 100853, P.R. China, Department of Geriatric Endocrinology, PLA General Hospital, Beijing 100853, P.R. China, Department of Geriatric Health Care, PLA General Hospital, Beijing 100853, P.R. China
Pages: 189-192
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Published online on: October 4, 2012

https://doi.org/10.3892/etm.2012.735
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Abstract

Non-traumatic rhabdomyolysis is a rare complication of acute pancreatitis. One of the major risk factors of both acute pancreatitis and rhabdomyolysis is alcohol abuse. However, only a few studies have reported the prognosis and association of severe acute pancreatitis (SAP) and rhabdomyolysis in alcohol abuse patients. In the present study, we report two cases presenting with SAP complicated by rhabdomyolysis following high-dose alcohol intake. The disease onset, clinical manifestations, laboratory data, diagnosis and treatment procedure of each patient were recorded, and the association with rhabdomyolysis was analyzed. Alcohol consumption was the most predominant cause of SAP and rhabdomyolysis in these patients. SAP-related rhabdomyolysis was primarily induced by the toxicity associated with pancreatic necrosis. The laboratory tests revealed that the concentration of serum creatine kinase (CK) and myoglobin increased and acute renal failure symptoms were present, which provided an exact diagnosis for SAP-induced rhabdomyolysis. Rhabdomyolysis and subsequent hypermyoglobinuria severely impaired kidney function and aggravated hypocalcemia. The therapy of early stage SAP complicated by rhabdomyolysis involved liquid resuscitation support. When first stage treatment fails, blood purification should be performed immediately. Both patients developed multiple organ failure (MOF) and succumbed to the disease. Considering the two cases presented, we conclude that alcohol-related SAP complicated by rhabdomyolysis may have a poor clinical prognosis.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Alcohol abuse-related severe acute pancreatitis with rhabdomyolysis complications

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